Prediction of Post-Weaning Fibrinogen Status during Cardiopulmonary Bypass: An Observational Study in 110 Patients.

BACKGROUND: After cardiac surgery with cardiopulmonary bypass (CPB), acquired coagulopathy often leads to post-CPB bleeding. Though multifactorial in origin, this coagulopathy is often aggravated by deficient fibrinogen levels. OBJECTIVE: To assess whether laboratory and thrombelastometric testing on CPB can predict plasma fibrinogen immediately after CPB weaning. PATIENTS / METHODS: This prospective study in 110 patients undergoing major cardiovascular surgery at risk of post-CPB bleeding compares fibrinogen level (Clauss method) and function (fibrin-specific thrombelastometry) in order to study the predictability of their course early after termination of CPB. Linear regression analysis and receiver operating characteristics were used to determine correlations and predictive accuracy. RESULTS: Quantitative estimation of post-CPB Clauss fibrinogen from on-CPB fibrinogen was feasible with small bias (+0.19 g/l), but with poor precision and a percentage of error >30%. A clinically useful alternative approach was developed by using on-CPB A10 to predict a Clauss fibrinogen range of interest instead of a discrete level. An on-CPB A10 ≤10 mm identified patients with a post-CPB Clauss fibrinogen of ≤1.5 g/l with a sensitivity of 0.99 and a positive predictive value of 0.60; it also identified those without a post-CPB Clauss fibrinogen <2.0 g/l with a specificity of 0.83. CONCLUSIONS: When measured on CPB prior to weaning, a FIBTEM A10 ≤10 mm is an early alert for post-CPB fibrinogen levels below or within the substitution range (1.5-2.0 g/l) recommended in case of post-CPB coagulopathic bleeding. This helps to minimize the delay to data-based hemostatic management after weaning from CPB

An ‘Ethical Black Box’, Learning From Disagreement in Shared Control Systems

Shared control, where a human user cooperates with an algorithm to operate a device, has the potential to greatly expand access to powered mobility, but also raises unique ethical challenges. A shared-control wheelchair may perform actions that do not reflect its user’s intent in order to protect their safety, causing frustration or distrust in the process. Unlike physical accidents there is currently no framework for investigating or adjudicating these events, leading to a reduced capability to improve the shared control algorithm’s user experience. In this paper we suggest a system based on the idea of an ‘ethical black box’ that records the sensor context of sub-critical disagreements and collision risks in order to allow human investigators to examine them in retrospect and assess whether the algorithm has taken control from the user without justification

SLE local martingales in logarithmic representations

A space of local martingales of SLE type growth processes forms a representation of Virasoro algebra, but apart from a few simplest cases not much is known about this representation. The purpose of this article is to exhibit examples of representations where L_0 is not diagonalizable - a phenomenon characteristic of logarithmic conformal field theory. Furthermore, we observe that the local martingales bear a close relation with the fusion product of the boundary changing fields. Our examples reproduce first of all many familiar logarithmic representations at certain rational values of the central charge. In particular we discuss the case of SLE(kappa=6) describing the exploration path in critical percolation, and its relation with the question of operator content of the appropriate conformal field theory of zero central charge. In this case one encounters logarithms in a probabilistically transparent way, through conditioning on a crossing event. But we also observe that some quite natural SLE variants exhibit logarithmic behavior at all values of kappa, thus at all central charges and not only at specific rational values.Comment: 40 pages, 7 figures. v3: completely rewritten, new title, new result

Wind on the boundary for the Abelian sandpile model

We continue our investigation of the two-dimensional Abelian sandpile model in terms of a logarithmic conformal field theory with central charge c=-2, by introducing two new boundary conditions. These have two unusual features: they carry an intrinsic orientation, and, more strangely, they cannot be imposed uniformly on a whole boundary (like the edge of a cylinder). They lead to seven new boundary condition changing fields, some of them being in highest weight representations (weights -1/8, 0 and 3/8), some others belonging to indecomposable representations with rank 2 Jordan cells (lowest weights 0 and 1). Their fusion algebra appears to be in full agreement with the fusion rules conjectured by Gaberdiel and Kausch.Comment: 26 pages, 4 figure

W-Extended Fusion Algebra of Critical Percolation

Two-dimensional critical percolation is the member LM(2,3) of the infinite series of Yang-Baxter integrable logarithmic minimal models LM(p,p'). We consider the continuum scaling limit of this lattice model as a `rational' logarithmic conformal field theory with extended W=W_{2,3} symmetry and use a lattice approach on a strip to study the fundamental fusion rules in this extended picture. We find that the representation content of the ensuing closed fusion algebra contains 26 W-indecomposable representations with 8 rank-1 representations, 14 rank-2 representations and 4 rank-3 representations. We identify these representations with suitable limits of Yang-Baxter integrable boundary conditions on the lattice and obtain their associated W-extended characters. The latter decompose as finite non-negative sums of W-irreducible characters of which 13 are required. Implementation of fusion on the lattice allows us to read off the fusion rules governing the fusion algebra of the 26 representations and to construct an explicit Cayley table. The closure of these representations among themselves under fusion is remarkable confirmation of the proposed extended symmetry.Comment: 30 page

Proposal for a CFT interpretation of Watts' differential equation for percolation

G. M. T. Watts derived that in two dimensional critical percolation the crossing probability Pi_hv satisfies a fifth order differential equation which includes another one of third order whose independent solutions describe the physically relevant quantities 1, Pi_h, Pi_hv. We will show that this differential equation can be derived from a level three null vector condition of a rational c=-24 CFT and motivate how this solution may be fitted into known properties of percolation.Comment: LaTeX, 20p, added references, corrected typos and additional content

Factorizable ribbon quantum groups in logarithmic conformal field theories

We review the properties of quantum groups occurring as Kazhdan--Lusztig dual to logarithmic conformal field theory models. These quantum groups at even roots of unity are not quasitriangular but are factorizable and have a ribbon structure; the modular group representation on their center coincides with the representation on generalized characters of the chiral algebra in logarithmic conformal field models.Comment: 27pp., amsart++, xy. v2: references added, some other minor addition

Fusion algebra of critical percolation

We present an explicit conjecture for the chiral fusion algebra of critical percolation considering Virasoro representations with no enlarged or extended symmetry algebra. The representations we take to generate fusion are countably infinite in number. The ensuing fusion rules are quasi-rational in the sense that the fusion of a finite number of these representations decomposes into a finite direct sum of these representations. The fusion rules are commutative, associative and exhibit an sl(2) structure. They involve representations which we call Kac representations of which some are reducible yet indecomposable representations of rank 1. In particular, the identity of the fusion algebra is a reducible yet indecomposable Kac representation of rank 1. We make detailed comparisons of our fusion rules with the recent results of Eberle-Flohr and Read-Saleur. Notably, in agreement with Eberle-Flohr, we find the appearance of indecomposable representations of rank 3. Our fusion rules are supported by extensive numerical studies of an integrable lattice model of critical percolation. Details of our lattice findings and numerical results will be presented elsewhere.Comment: 12 pages, v2: comments and references adde

Quantum-sl(2) action on a divided-power quantum plane at even roots of unity

We describe a nonstandard version of the quantum plane, the one in the basis of divided powers at an even root of unity $q=e^{i\pi/p}$. It can be regarded as an extension of the "nearly commutative" algebra $C[X,Y]$ with $X Y =(-1)^p Y X$ by nilpotents. For this quantum plane, we construct a Wess--Zumino-type de Rham complex and find its decomposition into representations of the $2p^3$-dimensional quantum group $U_q sl(2)$ and its Lusztig extension; the quantum group action is also defined on the algebra of quantum differential operators on the quantum plane.Comment: 18 pages, amsart++, xy, times. V2: a reference and related comments adde