231 research outputs found
Prevalence and definition of drooling in Parkinson’s disease: a systematic review
Drooling (saliva loss) is a frequently reported symptom in patients with Parkinson’s disease (PD), but an accurate estimate of the prevalence of drooling is lacking. The aim of this study was to systematically review the prevalence of drooling in published research papers. A systematic PubMed and CINAHL search was done, including studies published until January 2009. Eight studies were found, presenting prevalence rates of drooling based on responses of PD patients to questionnaires. The statistical heterogeneity was highly significant (P < 0.0001), with prevalence rates ranging from 32 to 74%. The pooled prevalence estimate with random effect analysis was of 56% (95% CI 44–67) for PD patients and 14% (95% CI 3–25) for healthy controls; the pooled relative risk (RR) with random effect analysis was 5.5 (95% CI 2.1–14.4). All studies reported data of community dwelling idiopathic PD patients, with a mean age around 65 years and mild PD in 50–60% of the cases. Heterogeneity was mainly caused by differences in definition or frequency of drooling. The highest prevalence rates included nocturnal drooling where others noted only diurnal drooling. Analysis of the data of two studies showed that drooling is reported frequently by 22–26% of the patients. Prevalence rates were lower in milder PD patients. The summarized findings demonstrate that drooling can be present in half of all PD patients. In about a quarter of PD patients, drooling appears to be a frequently occurring problem. We recommend to report drooling in future studies with more detailed consideration of severity, frequency and nocturnal versus diurnal complaints
Effects of Antiepileptic Drugs on GABA Responses and on Reduction of GABA Responses by PTZ and DMCM on Mouse Neurons in Cell Culture
The mechanisms of action of antiepileptic drugs effective against generalized absence seizures (antiabsence AEDs) remain uncertain. Antiabsence AEDs are generally effective against seizures induced in experimental animals by pentylenÉtÉtrazol (PTZ) and methyl-6,7-dimethoxy-4-ethyl-Β-carboline-3-carboxylate (DMCM), drugs which reduce GABAergic inhibition. Thus, antiabsence AEDs have been suggested to enhance GABAergic inhibition. We studied the effects of several AEDs on GABA responses recorded from mouse spinal cord neurons grown in primary dissociated cell culture. Four antiabsence AEDs were included: ethosuximide (ESM), dimethadione (DMO), sodium valproate (VPA), and diazepam (DZP). Two experimental AEDs, CGS 9896 and ZK 91296, with anticonvulsant action against PTZ- or DMCM-induced seizures were also included. Possible effects of the antiabsence and experimental AEDS on PTZ- and DMCM-induced inhibition of GABA responses were also evaluated. PTZ and DMCM revers-ibly reduced GABA responses in a concentration-dependent manner. PTZ complÉtÉly inhibited GABA responses at 10 mM (IC 50 of 1.1 mM), whereas DMCM-induced inhibition of GABA responses reached a plateau level of 39% of control values at 1 p.M (IC 50 of 33 nM). ESM (1,200 ΜM), DMO (6 mM), VPA (200 u.M), CGS 9896 (2 ΜM), and ZK 98% (2 Μ M ) did not alter GABA responses. DZP enhanced GABA responses in a concentration-dependent manner. The inhibition of GABA responses produced by PTZ 1 mM was unaltered by ESM (600 Μ M ), DMO (6 mM), CGS 9896 (1 Μ M), or ZK 9896 (1 ΜM)- Coapplication of VPA (200 ΜM) and PTZ (1 mM) slightly enhanced the PTZ effect. DZP (> 10 nM), however, reversed the PTZ-induced reduction of GABA responses. The DMCM (250 nM) inhibition of GABA-responses was unaltered by ESM (600 Μ.M), DMO (2 mM), or VPA (200 ΜM). CGS 9896 (2 Μ M ) and ZK 91296 (2 ΜM), however, antagonized the DMCM effect. DZP (> 10 nM) significantly reversed the DMCM-induced inhibition of GABA responses. The lack of effect of VPA, ESM, and DMO on postsynaptic GABA responses suggests that direct enhancement of postsynaptic GABA action is not a common mechanism of action of antiabsence AEDs. The AEDs DZP, CGS 98%, and ZK 912% all reversed DMCM, but not PTZ, reduction of GABA responses, suggesting that these AEDs blocked DMCM seizures by acting at benzodiazepine receptors. However, since only DZP enhanced GABA responses, it is unclear how CGS 98% and ZK 912% blocked PTZ seizures. Key Words: Anticonvulsants–GABA–Neuron culture–Cell culture–Spinal cord neurons–Convulsants. RESUMEN Los mecanismos de accidn de las medicaciones antiepilÉpticas eficaces contra los ataques generalizados de ausencia (AEDs antiausencia) permanecen inciertos. Los AEDs antiausencia son, generalmente, eficaces contra ataques experimentales inducidos por el pentilentetrazol (PTZ) y el metil-6,7-dimetoxy-4-etil-Pcarbolina-3-carboxilato (DMCM) en animates, medicaciones que reducen la inhibiciÓn GABAÉrgica. Hemos estudiado los efectos de varios AEDs sobre respuestas-GABA registradas en las neuronas de la mÉdula espinal de ratones que habian crecido en cultivos de cÉlulas primarieas disociadas. Cuatro AEDs antiausencia fueron incluidos: etoxusimida (ESM), dimetadiona (DMO), valproato sÓdico (VPA) y diazepan (DZP). TambtÉn se incluyeron dos AEDs experimentales, CGS 9896 y ZK 912%, con acciÓn anticonvulsiva contra los ataques inducidos por PTZ o DMCM. TambiÓn se valoraron los posibles efectos de los AEDs antiausencia y experimentales sobre el PTZ y la inhibiciÓn de las respuestas-GABA inducidas por el DMCM. El PTZ y el DMCM redujeron las respuestas-GABA de modo reversible y dependiendo de sus concentraciones. El PTZ inhibiÓ cmpleta-mente las respuestas-GABA a 10 mM (IC 50 de 1.1 mM) mientras que la inhibitiÓn de las respuestas GABA inducida por el DMCM alcanzÓ un nivel estable del 39% de los valores control con 1 Μ. M (IC 50 de 33 mM). La ESM (1200 Μ.M), la DMO (6 mM), el VPA (200 Μ M ), el CGS 98% (2 Μ M) y el ZK 98% (2 Μ M) no alteraron las respuestas-GABA. El DZP aumentÓ las respuestas GABA de una manera concentraciÓn-dependiente. La inhibition de las respuestas-GABA producidas por el PTZ (1 mM), no se altero con las ESM (600 Μ M), la DMO (6 mM), el CGS 98% (1 Μ M) o el ZK 98% (1 Μ .M). La co-aplicacion de VPA (200 Μ M) y el PTZ (1 mM) aument6 ligeramente los efectos del PTZ. Sin embargo el DZP (10 nM) revirtiÓ significativamente la inhibition de las respuestas GABA inducidas por el DMCM. La falta de efectos de CPA, ESM y DMO sobre las respuestas GABA post-sinÁpticas sugiere que el incremento de la acciÓn GABA post-sinÁptica no es un mecanismo comÚn de actuatiÓn de las AEDs antiausencia. Todas las AEDs DZP, CGS 98% y ZK 912% revirtieron la reduction de las respuestas GABA producidas por el DMCM pero no las inducidas por el PTZ lo que sugiere que estos AEDs bloquean los ataques DMCM actuando sobre los receptores de la benzodiazepina. Sin embargo, puesto que el incremento de las respuestas GABA sÓlÓ se produce por el DZP, permanece todavia sin aclarar el por quÉ el CGS 98% y el ZK 912% bloquean los ataques producidos por el PTZ. ZUSAMMENFASSUNG Der Wirkmechansimus von Antiepileptika gegen generalisierte Absencen ist unklar. Antiabsencemittel sind generell wirkungs-voll gegen PTZ- und Methyl-6,7-Dimethoxy-4-Äthyl-P-Carbolin-Β-Carboxylat (DMCM) induzierte tierexperimentelle AnfÄlle, also von Medikamenten, die die GABA-erge Inhibition reduzieren. Es wurde vermutet, daß Antiabsencemittel die GABA-erge Inhibition verstÄrken. Wir untersuchten die Wirkung von verschiedenen Antiepileptika auf GABA-Antworten in spinalen MÄuseneuronen, die in Zellkulturen gew-achsen waren. Es wurden 4 Absencemittel untersucht: Ethosux-imid (ESM), Dimethadion (DMD), Sodium Valproat (VPA) und Diazepam (DZP). ZusÄtzlich wurden 2 experimentelle Antiepileptika, CGS 98% und ZK 912%, die gegen PTZ0 oder DMCM-induzierte AnfÄlle wirkungsvoll sind, eingeschlossen. Mogliche Wirkungen der Antiabsence- und experimentellen Antiepileptika auf PTZ- und DMCM-induzierte Hemmung der GABA-Antworten wurden ebenfalls ausgewertet. PTZ und DMCM zeigten eine konzentrationsabhÄngige reversible Reduktion der GABA-Antworten. PTZ zeigte eine komplette Hemmung der GABA-Antworten bei 10 mM (IC 50 1,1 mM), DMCM-Hemmung der GABA-Antworten zeigte ein Plateau von 39% der Kontroll-werte bei 1 uJtf (ICJO von 33 mAfl. ESM (1200 uJtf), DMD (6 mM), VPA (200 Μ M), CGS 98% (2 Μ M) und ZK 98% (2 Μ M) anderten nicht die GABA-Antworten. DZP verstarkte die GABA-Antworten konzentrationsabhangig. Die durch PTZ (1 mM) hervorgerufene Hemmung der GABA-Antworten war bei ESM (600 Μ M), DMD (6 mM), CGS 98% (1 mAO und ZK 3836 (1 mM) unverÄndert. ZusÄtliche Anwendung von VPA (200 mM) und PTZ (1 mM) verstÄrkten geringfÜgig den PTZ-Effekt. DZP (10 nM) kehrte die durch PTZ hervorgerufene Reduktion der GABA-Antworten um. Die durch DMCM (250 nM) hervorgerufene Hemmung der GABA-Antworten war durch ESM (600 Μ .M), DMD (2 mM) und VPA (200 Μ M ) unbeeinflusst. CGS 98% (2 Μ M) und ZK 912% (2 Μ M ) antagonisierten die DMCM-Wirkung. DZP (>10 nM) kehrte die durch DMCM-induzierte Hemmung der GABA-Antworten um. Das Fehlen einer Wirkung von VPA. ESM und DMD auf die postsynaptischen GABA-Antworten legen nahe, daß eine direkte VerstÄrkung der postsynaptischen GABA-Aktion kein gemeinsamer Mechanis-mus der Antiabsencemittel darstellt. Die Antiepileptika DZP, CGS 98% und ZK 912% kehrten die DMCM-Wirkung auf die GABA-Antworten um, jedoch nicht die von PTZ, was vermuten lapt, daß diese Antiepileptika die DMCM-AnfÄlle Über die Wirkung an den Benzodiazipin-Rezeptoren verhinderte. Da jedoch nur DZP GABA-Antworten verstarkte, ist unklar, in welcher Weise CGS 98% und ZK 912% die PTZ-AnfaUe ver-hinderten.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65188/1/j.1528-1157.1989.tb05275.x.pd
Increased incidence of kidney diseases in general practice after a nationwide albuminuria self-test program
<p>Abstract</p> <p>Background</p> <p>To study the influence of a nationwide albuminuria self-test program on the number of GP contacts for urinary complaints and/or kidney diseases and the number of newly diagnosed patients with kidney diseases by the GP.</p> <p>Methods</p> <p>Data were used from the Netherlands Information Network of General Practice (LINH), including a representative sample of general practices with a dynamic population of approximately 300.000 listed patients. Morbidity data were retrieved from electronic medical records, kept in a representative sample of general practices. The incidence of kidney diseases and urinary complaints before and after the albuminuria self-test program was compared with logistic regression analyses.</p> <p>Results</p> <p>Data were used from 139 general practices, including 444,220 registered patients. The number of GP consultations for kidney diseases and urinary complaints was increased in the year after the albuminuria self-test program and particularly shortly after the start of the program. Compared with the period before the self-test program, more patients have been diagnosed by the GP with symptoms/complaints of kidney disease and urinary diseases (OR = 1.7 (CI 1.4 - 2.0) and OR = 2.1 (CI 1.9 - 2.3), respectively). The odds on an abnormal urine-test in the period after the self-test program was three times higher than the year before (OR = 3.0 (CI 2.4 - 3.6)). The effect of the self-test program on newly diagnosed patients with an abnormal urine test was modified by both the presence of the risk factors hypertension and diabetes mellitus. For this diagnosis the highest OR was found in patients without both conditions (OR = 4.2 (CI 3.3 - 5.4)).</p> <p>Conclusions</p> <p>A nationwide albuminuria self-test program resulted in an increasing number of newly diagnosed kidney complaints and diseases the year after the program. The highest risks were found in patients without risk factors for kidney diseases.</p
Successful recanalization for internal carotid artery occlusion with persistent primitive trigeminal artery manifesting only as ischemia of the posterior circulation
Drug-prescribing patterns during pregnancy in the tertiary care hospitals of Pakistan: a cross sectional study
<p>Abstract</p> <p>Background</p> <p>The rationale for use of drugs during pregnancy requires a careful assessment as in addition to the mother, the health and life of her unborn child is also at stake. Information on the use of drugs during pregnancy is not available in Pakistan. The aim of this study was to evaluate the patterns of drug prescriptions to pregnant women in tertiary care hospitals of Pakistan.</p> <p>Methods</p> <p>This was a cross-sectional study conducted at five tertiary care hospitals of Pakistan. Copies of outpatient medicinal prescriptions given to pregnant patients attending the antenatal clinics were collected. The drugs were classified according to the pharmacological class and their teratogenic potential.</p> <p>Results</p> <p>All the pregnant women attending the antenatal clinics received a prescription containing at least one drug. A total of 3769 distinct prescriptions given to different women were collected. Majority of the women who received the prescriptions belonged to third trimester (55.4%) followed by second (33.6%) and first trimester (11.0%). On an average, each prescription contained 1.66 ± 0.14 drugs. The obstetricians at Civil Hospital, Karachi and Chandka Medical College Hospital, Larkana showed a tendency of prescribing lesser number of drugs compared to those in other hospitals. Anti-anemic drugs including iron preparations and vitamin and mineral supplements (79.4%) were the most frequently prescribed drugs followed by analgesics (6.2%) and anti-bacterials (2.2%). 739 women (19.6%) received prescriptions containing drugs other than vitamin or mineral supplements. Only 1275 (21.6%) of all the prescribed drugs (n = 6100) were outside this vitamin/mineral supplement class. Out of these 1275 drugs, 29 (2.3%) drugs were prescribed which are considered to be teratogenic. Misoprostol was the most frequently prescribed (n = 6) among the teratogenic drugs followed by carbimazole (n = 5) and methotrexate (n = 5). Twenty nine pregnant women (0.8% of all the women studied) were prescribed these teratogenic drugs.</p> <p>Conclusion</p> <p>Less than one percent of the pregnant women attending tertiary care hospitals in Pakistan are prescribed teratogenic drugs. The prescribing practices of Pakistani physicians are similar to those in western countries.</p
What do clinicians want? Interest in integrative health services at a North Carolina academic medical center
BACKGROUND: Use of complementary medicine is common, consumer driven and usually outpatient focused. We wished to determine interest among the medical staff at a North Carolina academic medical center in integrating diverse therapies and services into comprehensive care. METHODS: We conducted a cross sectional on-line survey of physicians, nurse practitioners and physician assistants at a tertiary care medical center in 2006. The survey contained questions on referrals and recommendations in the past year and interest in therapies or services if they were to be provided at the medical center in the future. RESULTS: Responses were received from 173 clinicians in 26 different departments, programs and centers. There was strong interest in offering several specific therapies: therapeutic exercise (77%), expert consultation about herbs and dietary supplements (69%), and massage (66%); there was even stronger interest in offering comprehensive treatment programs such as multidisciplinary pain management (84%), comprehensive nutritional assessment and advice (84%), obesity/healthy lifestyle promotion (80%), fit for life (exercise and lifestyle program, 76%), diabetes healthy lifestyle promotion (73%); and comprehensive psychological services for stress management, including hypnosis and biofeedback (73%). CONCLUSION: There is strong interest among medical staff at an academic health center in comprehensive, integrated services for pain, obesity, and diabetes and in specific services in fitness, nutrition and stress management. Future studies will need to assess the cost-effectiveness of such services, as well as their financial sustainability and impact on patient satisfaction, health and quality of life
A state-of-the-art review of curve squeal noise: Phenomena, mechanisms, modelling and mitigation
[EN] Curve squeal is an intense tonal noise occurring when a rail vehicle negotiates a sharp curve. The phenomenon can be considered to be chaotic, with a widely differing likelihood of occurrence on different days or even times of day. The term curve squeal may include several different phenomena with a wide range of dominant frequencies and potentially different excitation mechanisms. This review addresses the different squeal phenomena and the approaches used to model squeal noise; both time-domain and frequency-domain approaches are discussed and compared. Supporting measurements using test rigs and field tests are also summarised. A particular aspect that is addressed is the excitation mechanism. Two mechanisms have mainly been considered in previous publications. In many early papers the squeal was supposed to be generated by the so-called falling friction characteristic in which the friction coefficient reduces with increasing sliding velocity. More recently the mode coupling mechanism has been raised as an alternative. These two mechanisms are explained and compared and the evidence for each is discussed. Finally, a short review is given of mitigation measures and some suggestions are offered for why these are not always successful.Squicciarini, G.; Thompson, D.; Ding, B.; Baeza González, LM. (2018). A state-of-the-art review of curve squeal noise: Phenomena, mechanisms, modelling and mitigation. Notes on Numerical Fluid Mechanics and Multidisciplinary Design. 139:3-41. https://doi.org/10.1007/978-3-319-73411-8_1S341139Anderson, D., Wheatley, N., Fogarty, B., Jiang, J., Howie, A., Potter, W.: Mitigation of curve squeal noise in Queensland, New South Wales and South Australia. In: Conference on Railway Engineering. pp. 625–636, Perth, Australia (2008)Hanson, D., Jiang, J., Dowdell, B., Dwight, R.: Curve squeal: causes, treatments and results. In INTER-NOISE and NOISE-CON Congress and Conference Proceedings, vol. 249, pp. 6316–6323. Melbourne, Australia (2014)Rudd, M.J.: Wheel/rail noise—part II: wheel squeal. J. Sound Vib. 46(3), 381–394 (1976)Remington, P.J.: Wheel/rail squeal and impact noise: what do we know? What don’t we know? Where do we go from here? J. Sound Vib. 116(2), 339–353 (1987)Remington, P.J.: Wheel/rail rolling noise: what do we know? What don’t we know? Where do we go from here? J. Sound Vib. 120(2), 203–226 (1988)Wickens, A.H.: Fundamentals of Rail Vehicle Dynamics, Guidance and Stability. Swets & Zeitlinger, Lisse (2003)Thompson, D.J.: Railway Noise and Vibration: Mechanisms, Modelling and Mitigation. Elsevier, Oxford (2009)Kalker, J.J.: Three Dimensional Elastic Bodies in Rolling Contact. Kluwer academic publishers, Dordrecht (1990)Vermeulen, P.J., Johnson, K.L.: Contact of nonspherical elastic bodies transmitting tangential forces. J. Appl. Mech. 31(2), 338–340 (1964)Shen, Z.Y., Hedrick, J.K., Elkins, J.A.: A comparison of alternative creep-force models for rail vehicle dynamic analysis. In: Proceedings of 8th IAVSD Symposium, Cambridge MA, Swets and Zeitlinger, Lisse, pp. 591–605 (1983)Huang, Z.Y.: Theoretical Modelling of Railway Curve Squeal. Ph.D. thesis, University of Southampton, UK (2007)Hoffmann, N., Fischer, M., Allgaier, R., Gaul, L.: A minimal model for studying properties of the mode-coupling type instability in friction induced oscillations. Mech. Res. Commun. 29(4), 197–205 (2002)Hoffmann, N., Gaul, L.: Effects of damping on mode-coupling instability in friction induced oscillations. J. Appl. Math. Mech. 83(8), 524–534 (2003)Sinou, J.J., Jezequel, L.: Mode coupling instability in friction-induced vibrations and its dependency on system parameters including damping. Eur. J. Mech.-A/Solids 26(1), 106–122 (2007)Johnson, K.L.: Contact Mechanics. Cambridge University Press, Cambridge (1985)Kinkaid, N.M., O’Reilly, O.M., Papadopoulos, P.: Automotive disc brake squeal. J. Sound Vib. 267(1), 105–166 (2003)Ghazaly, N.M., El-Sharkawy, M., Ahmed, I.: A review of automotive brake squeal mechanisms. J. Mech. Des. Vibr. 1(1), 5–9 (2013)Ouyang, H., Nack, W., Yuan, Y., Chen, F.: Numerical analysis of automotive disc brake squeal: a review. Int. J. Veh. Noise Vib. 1(3–4), 207–231 (2005)Dorf, R.C., Bishop, R.H.: Modern Control Systems, 11th edn. Prentice Hall. (2008)De Beer, F.G., Janssens, M.H.A., Kooijman, P.P., van Vliet, W.J.: Curve squeal of railbound vehicles (part 1): frequency domain calculation model. In: Proceedings of Internoise, vol. 3, pp. 1560–1563. Nice, France (2000)Von Stappenbeck, H.: Das Kurvengeräusch der Straßenbahn. Möglichkeiten zu seiner Unterdrückung. Z. VDI 96(6), 171–175 (1954)Van Ruiten, C.J.M.: Mechanism of squeal noise generated by trams. J. Sound Vib. 120(2), 245–253 (1988)Nakai, M., Chiba, Y., Yokoi, M.: Railway wheel squeal: 1st report, on frequency of squeal. Bull. Jpn. Soc. Mech. Eng. 25, 1127–1134 (1982)Nakai, M., Chiba, Y., Yokoi, M.: Railway wheel squeal: 2nd report, mechanism of specific squeal frequency. Bull. Jpn. Soc. Mech. Eng. 27, 301–308 (1984)Nakai, M., Chiba, Y., Yokoi, M.: Railway wheel squeal: 3rd report, squeal of a disk simulating a wheel in internal resonances. Bull. Jpn. Soc. Mech. Eng. 28, 500–507 (1985)Schneider, E., Popp, K., Irretier, H.: Noise generation in railway wheels due to rail-wheel contact forces. J. Sound Vib. 120(2), 227–244 (1988)Kraft, K.: Der Einfluß der Fahrgeschwindigkeit auf den Haftwert zwischen Rad und Schiene. Arch. für Eisenbahntechnik 22, 58–78 (1967)Fingberg, U.: A model of wheel-rail squealing noise. J. Sound Vib. 143(3), 365–377 (1990)Périard, F.: Wheel-Rail Noise Generation: Curve Squealing by Trams. Ph.D. thesis, Technische Universiteit Delft (1998)Heckl, M.A., Abrahams, I.D.: Curve squeal of train wheels, part 1: mathematical model for its generation. J. Sound Vib. 229(3), 669–693 (2000)Heckl, M.A.: Curve squeal of train wheels, part 2: which wheel modes are prone to squeal? J. Sound Vib. 229(3), 695–707 (2000)Heckl, M.A.: Curve squeal of train wheels: unstable modes and limit cycles. Proc. R. Soc. Lond. A: Math. Phys. Eng. Sci. 458, 1949–1965 (2002)Liu, X., Meehan, P.A.: Wheel squeal noise: a simplified model to simulate the effect of rolling speed and angle of attack. J. Sound Vib. 338, 184–198 (2015)Meehan, P.A., Liu, X.: Analytical prediction and investigation of wheel squeal amplitude. In: Anderson, D., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 139, pp 69–80. Springer, Heidelberg (2018)Kooijman, P.P., Van Vliet, W.J., Janssens, M.H.A., De Beer, F.G.: Curve squeal of railbound vehicles (part 2): set-up for measurement of creepage dependent friction coefficient. In: Proceedings of Internoise, vol. 3, pp. 1564–1567. Nice, France (2000)De Beer, F.G., Janssens, M.H.A., Kooijman, P.P.: Squeal noise of rail-bound vehicles influenced by lateral contact position. J. Sound Vib. 267(3), 497–507 (2003)Thompson, D.J., Hemsworth, B., Vincent, N.: Experimental validation of the TWINS prediction program for rolling noise, part 1: description of the model and method. J. Sound Vib. 193(1), 123–135 (1996)Monk-Steel, A., Thompson, D.J.: Models for railway curve squeal noise. In: VIII International Conference on Recent Advances in Structural Dynamics, Southampton, UK (2003)Barman, J.F., Katzenelson, J.: A generalized Nyquist-type stability criterion for multivariable feedback systems. Int. J. Control 20(4), 593–622 (1974)Huang, Z.Y., Thompson, D.J., Jones, C.J.C.: Squeal prediction for a bogied vehicle in a curve. In Schulte-Werning, B., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM vol. 99, pp. 313–319. Springer, Heidelberg (2008)Hsu, S.S., Huang, Z., Iwnicki, S.D., Thompson, D.J., Jones, C.J., Xie, G., Allen, P.D.: Experimental and theoretical investigation of railway wheel squeal. Proc. Inst. Mech. Eng. Part F: J. Rail Rapid Transit 221(1), 59–73 (2007)Squicciarini, G., Usberti, S., Thompson, D.J., Corradi, R., Barbera, A.: Curve squeal in the presence of two wheel/rail contact points. In: Nielsen, J.C.O., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 126, pp. 603–610. Springer, Heidelberg (2015)Xie, G., Allen, P.D., Iwnicki, S.D., Alonso, A., Thompson, D.J., Jones, C.J., Huang, Z.Y.: Introduction of falling friction coefficients into curving calculations for studying curve squeal noise. Veh. Syst. Dyn. 44(sup1), 261–271 (2006)Giménez, J.G., Alonso, A., Gómez, E.: Introduction of a friction coefficient dependent on the slip in the FastSim algorithm. Veh. Syst. Dyn. 43(4), 233–244 (2005)Chiello, O., Ayasse, J.B., Vincent, N., Koch, J.R.: Curve squeal of urban rolling stock—part 3: theoretical model. J. Sound Vib. 293(3), 710–727 (2006)Collette, C.: Importance of the wheel vertical dynamics in the squeal noise mechanism on a scaled test bench. Shock Vibr. 19(2), 145–153 (2012)Brunel, J.F., Dufrénoy, P., Naït, M., Muñoz, J.L., Demilly, F.: Transient models for curve squeal noise. J. Sound Vib. 293(3), 758–765 (2006)Glocker, C., Cataldi-Spinola, E., Leine, R.I.: Curve squealing of trains: measurement, modelling and simulation. J. Sound Vib. 324(1), 365–386 (2009)Pieringer, A.: A numerical investigation of curve squeal in the case of constant wheel/rail friction. J. Sound Vib. 333(18), 4295–4313 (2014)Pieringer, A., Kropp, W.: A time-domain model for coupled vertical and tangential wheel/rail interaction—a contribution to the modelling of curve squeal. In: Maeda, T., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 118, pp. 221–229. Springer, Heidelberg (2012)Pieringer, A., Baeza, L., Kropp. W.: Modelling of railway curve squeal including effects of wheel rotation. In: Nielsen, J.C.O., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 126, pp. 417–424. Springer, Heidelberg (2015)Zenzerovic, I., Pieringer, A., Kropp. W.: Towards an engineering model for curve squeal. In: Nielsen, J.C.O., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 126, pp. 433–440. Springer, Heidelberg (2015)Zenzerovic, I., Kropp, W., Pieringer, A.: An engineering time-domain model for curve squeal: tangential point-contact model and Green’s functions approach. J. Sound Vib. 376, 149–165 (2016)Pieringer, A., Torstensson, P.T., Giner, J., Baeza, L.: Investigation of railway curve squeal using a combination of frequency- and time-domain models. In: Anderson, D., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 139, pp 81–93. Springer, Heidelberg (2018)Chen, G.X., Xiao, J.B., Liu, Q.Y., Zhou. Z.R.: Complex eigenvalue analysis of railway curve squeal. In: Schulte-Werning, B., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 99, pp. 433–439. Springer, Heidelberg (2008)Fourie, D.J., Gräbe, P.J., Heyns, P.S., Fröhling, R.D.: Analysis of wheel squeal due to unsteady longitudinal creepage using the complex eigenvalue method. In: Anderson, D., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 139, pp 55–67. Springer, Heidelberg (2018)Wang, C., Dwight, R., Li, W., Jiang, J.: Prediction on curve squeal in the case of constant wheel rail friction coefficient. In: Anderson, D., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 139, pp XXX–XXX. Springer, Heidelberg (2018)Ding, B., Squicciarini, G., Thompson, D.J.: Effects of rail dynamics and friction characteristics on curve squeal. In: XIII International Conference on Motion and Vibration Control and XII International Conference on Recent Advances in Structural Dynamics (MoViC/RASD), Southampton (2016)Bleedorn, T.G., Johnstone. B.: Steerable steel wheel systems and wheel noise suppression. In: Conference Rec IAS 12th Annual Meeting, Los Angeles, California (1977)Koch, J.R., Vincent, N., Chollet, H., Chiello, O.: Curve squeal of urban rolling stock—part 2: parametric study on a 1/4 scale test rig. J. Sound Vib. 293(3), 701–709 (2006)Logston, C.F., Itami, G.S.: Locomotive friction-creep studies. ASME J. Eng. Ind. 102(3), 275–281 (1980)Ertz, M.: Creep force laws for wheel/rail contact with temperature-dependent coefficient of friction. In: 8th Mini Conference on Vehicle System Dynamics, Identification and Anomalies, Budapest (2002)Lang, W., Roth, R.: Optimale Kraftschlussausnutzung bei Hochleistungs-Schienenfahrzeugen. Eisenbahntechnische Rundsch. 42, 61–66 (1993)Polach, O.: Creep forces in simulations of traction vehicles running on adhesion limit. Wear 258(7), 992–1000 (2005)Zhang, W., Chen, J., Wu, X., Jin, X.: Wheel/rail adhesion and analysis by using full scale roller rig. Wear 253(1), 82–88 (2002)Harrison, H., McCanney, T., Cotter, J.: Recent developments in coefficient of friction measurements at the rail/wheel interface. Wear 253(1), 114–123 (2002)Gallardo-Hernandez, E.A., Lewis, R.: Twin disc assessment of wheel/rail adhesion. Wear 265(9), 1309–1316 (2008)Fletcher, D.I., Lewis, S.: Creep curve measurement to support wear and adhesion modelling, using a continuously variable creep twin disc machine. Wear 298–299, 57–65 (2013)Fletcher, D.I.: A new two-dimensional model of rolling–sliding contact creep curves for a range of lubrication types. Proc. Inst. Mech. Eng. Part J: J. Eng. Tribol. 227(6), 529–537 (2013)Matsumoto, A., Sato, Y., Ono, H., Wang, Y., Yamamoto, M., Tanimoto, M., Oka, Y.: Creep force characteristics between rail and wheel on scaled model. Wear 253(1), 199–203 (2002)Janssens, M.H.A., van Vliet, W.J., Kooijman, P.P., De Beer, F.G.: Curve squeal of railbound vehicles (part 3): measurement method and results. In: Proceedings of Internoise, vol. 3, pp. 1568–1571, Nice, France (2000)Monk-Steel, A.D., Thompson, D.J., De Beer, F.G., Janssens, M.H.A.: An investigation into the influence of longitudinal creepage on railway squeal noise due to lateral creepage. J. Sound Vib. 293(3), 766–776 (2006)Liu, X., Meehan, P.A.: Investigation of the effect of lateral adhesion and rolling speed on wheel squeal noise. Proc. Inst. Mech. Eng. Part F: J. Rail Rapid Transit 227(5), 469–480 (2013)Liu, X., Meehan, P.A.: Investigation of the effect of relative humidity on lateral force in rolling contact and curve squeal. Wear 310(1), 12–19 (2014)Liu, X., Meehan, P.A.: Investigation of squeal noise under positive friction characteristics condition provided by friction modifiers. J. Sound Vib. 371, 393–405 (2016)Jie, E., Kim, J.Y., Hwang, D.H., Lee, J.H., Kim, K.J., Kim, J.C.: An experimental study of squeal noise characteristics for railways using a scale model test rig. In: J. Pombo (ed.) Proceedings of the Third International Conference on Railway Technology: Research, Development and Maintenance, Cagliari, Sardinia, Italy (2016)Eadie, D.T., Santoro, M., Kalousek, J.: Railway noise and the effect of top of rail liquid friction modifiers: changes in sound and vibration spectral distributions in curves. Wear 258(7), 1148–1155 (2005)Bullen, R., Jiang, J.: Algorithms for detection of rail wheel squeal. In: 20th International Congress on Acoustics 2010, ICA 2010—Incorporating Proceedings of the 2010 Annual Conference of the Australian Acoustical Society. pp. 2212–2216 (2010)Stefanelli, R., Dual, J., Cataldi-Spinola, E.: Acoustic modelling of railway wheels and acoustic measurements to determine involved eigenmodes in the curve squealing phenomenon. Veh. Syst. Dyn. 44(sup1), 286–295 (2006)Vincent, N., Koch, J.R., Chollet, H., Guerder, J.Y.: Curve squeal of urban rolling stock—part 1: state of the art and field measurements. J. Sound Vib. 293(3), 691–700 (2006)Anderson, D., Wheatley, N.: Mitigation of wheel squeal and flanging noise on the Australian network. In: Schulte-Werning, B., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 99, pp. 399–405. Springer, Heidelberg (2008)Curley, D., Anderson, D.C., Jiang, J., Hanson, D.: Field trials of gauge face lubrication and top-of-rail friction modification for curve noise mitigation. In: Nielsen, J.C.O., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 126, pp. 449–456. Springer, Heidelberg (2015)Jiang, J., Hanson, D., Dowdell, B.: Wheel squeal—insights from wayside condition monitoring measurements and field trials. In: Anderson, D., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 139, pp 41–53. Springer, Heidelberg (2018)Jiang, J., Dwight, R., Anderson, D.: Field verification of curving noise mechanisms. In: Maeda, T., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 118, pp. 349–356. Springer, Heidelberg (2012)Jiang, J., Anderson, D.C., Dwight, R.: The mechanisms of curve squeal. In: Nielsen, J.C.O., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 126, pp. 587–594. Springer, Heidelberg (2015)Fourie, D.J., Gräbe, P.J., Heyns, P.S., Fröhling, R.D.: Experimental characterisation of railway wheel squeal occurring in large-radius curves. Proc. Inst. Mech. Eng. Part F: J. Rail Rapid Transit 230(6), 1561–1574 (2016)Corradi, R., Crosio, P., Manzoni, S., Squicciarini, G.: Experimental investigation on squeal noise in tramway sharp curves. In: Proceedings of the 8th International Conference on Structural Dynamics, EURODYN 2011, Leuven (2011)Merideno, I., Nieto, J., Gil-Negrete, N., Landaberea, A., Iartza, J.: Constrained layer damper modelling and performance evaluation for eliminating squeal noise in trams. Shock and Vibration (2014)Nelson J.T.: Wheel/rail noise control manual, TCRP Report 23 (1997)Krüger, F.: Schall- und Erschütterungsschutz im Schienenverkehr. Expert Verlag, Renningen (2001)Elbers, F., Verheijen, E.: Railway noise technical measures catalogue, UIC report UIC003-01-04fe (2013)Oertli, J.: Combatting curve squeal, phase II, final report, UIC (2005)Eadie, D.T., Santoro, M., Powell, W.: Local control of noise and vibration with KELTRACK™ friction modifier and protector® trackside application: an integrated solution. J. Sound Vib. 267(3), 761–772 (2003)Eadie, D.T., Santoro, M.: Top-of-rail friction control for curve noise mitigation and corrugation rate reduction. J. Sound Vib. 293(3), 747–757 (2006)Suda, Y., Iwasa, T., Komine, H., Tomeoka, M., Nakazawa, H., Matsumoto, K., Nakai, T., Tanimoto, M., Kishimoto, Y.: Development of onboard friction control. Wear 258(7), 1109–1114 (2005)Bühler, S., Thallemer, B.: How to avoid squeal noise on railways: state of the art and practical experience. In: Schulte-Werning, B., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 99, pp. 406–411. Springer, Heidelberg (2008)Jones, C.J.C., Thompson, D.J.: Rolling noise generated by railway wheels with visco-elastic layers. J. Sound Vib. 231(3), 779–790 (2000)Wetta, P., Demilly, F.: Reduction of wheel squeal noise generated on curves or during braking. In 11th International of Wheelset Congress, Paris (1995)Brunel, J.F., Dufrénoy, P., Demilly, F.: Modelling of squeal noise attenuation of ring damped wheels. Appl. Acoust. 65(5), 457–471 (2004)Marjani, S.R., Younesian, D.: Suppression of train wheel squeal noise by shunted piezoelectric elements. Int. J. Struct. Stab. Dyn. (2016)Heckl, M.A., Huang, X.Y.: Curve squeal of train wheels, part 3: active control. J. Sound Vib. 229(3), 709–735 (2000)Thompson, D.J., Jones, C.J.C., Waters, T.P., Farrington, D.: A tuned damping device for reducing noise from railway track. Appl. Acoust. 68(1), 43–57 (2007)Jiang, J., Ying, I., Hanson, D., Anderson, D.C.: An investigation of the influence of track dynamics on curve noise. In: Nielsen, J.C.O., et al. (eds.) Noise and Vibration Mitigation for Rail Transportation Systems. NNFM, vol. 126, pp. 441–448. Springer, Heidelberg (2015)Toward, M., Squicciarini, G., Thompson, D.J.: Reducing freight wagon noise at source. Int. Railway J. March, 47–49 (2015)Illingworth, R., Pollard, M.G.: The use of steering axle suspensions to reduce wheel and rail wear in curves. Proc. Inst. Mech. Eng. 196(1), 379–385 (1982)Garcia, J.F., Olaizola, X., Martin, L.M., Gimenez, J.G.: Theoretical comparison between different configurations of radial and conventional bogies. Veh. Syst. Dyn. 33(4), 233–259 (2000)Bruni, S., Goodall, R., Mei, T.X., Tsunashima, H.: Control and monitoring for railway vehicle dynamics. Veh. Syst. Dyn. 45(7–8), 743–779 (2007)Hiensch, M., Larsson, P.O., Nilsson, O., Levy, D., Kapoor, A., Franklin, F., Nielsen, J., Ringsberg, J., Josefson, L.: Two-material rail development: field test results regarding rolling contact fatigue and squeal noise behaviour. Wear 258(7), 964–972 (2005)Kopp, E.: Fünf Jahre Erfahrungen mit asymmetrisch geschliffenen Schienenprofilen. Eisenbahn Techn. Rundsch. 40, 665 (1991
Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-13C6]-d-glucose tracer in mice
Previous genetic and proteomic studies identified altered activity of various enzymes such as those of fatty acid metabolism and glycogen synthesis after a single toxic dose of valproic acid (VPA) in rats. In this study, we demonstrate the effect of VPA on metabolite synthesis flux rates and the possible use of abnormal 13C labeled glucose-derived metabolites in plasma or urine as early markers of toxicity. Female CD-1 mice were injected subcutaneously with saline or 600 mg/kg) VPA. Twelve hours later, the mice were injected with an intraperitoneal load of 1 g/kg [U-13C]-d-glucose. 13C isotopomers of glycogen glucose and RNA ribose in liver, kidney and brain tissue, as well as glucose disposal via cholesterol and glucose in the plasma and urine were determined. The levels of all of the positional 13C isotopomers of glucose were similar in plasma, suggesting that a single VPA dose does not disturb glucose absorption, uptake or hepatic glucose metabolism. Three-hour urine samples showed an increase in the injected tracer indicating a decreased glucose re-absorption via kidney tubules. 13C labeled glucose deposited as liver glycogen or as ribose of RNA were decreased by VPA treatment; incorporation of 13C via acetyl-CoA into plasma cholesterol was significantly lower at 60 min. The severe decreases in glucose-derived carbon flux into plasma and kidney-bound cholesterol, liver glycogen and RNA ribose synthesis, as well as decreased glucose re-absorption and an increased disposal via urine all serve as early flux markers of VPA-induced adverse metabolic effects in the host
Livelihood and vulnerability in the wake of Typhoon Yolanda: lessons of community and resilience
Livelihood strategies that are crafted in ‘extra-ordinary’ post-disaster conditions should
also be able to function once some semblance of normalcy has resumed. This article aims
to show that the vulnerability experienced in relation to Typhoon Yolanda was, and continues to be, directly linked to inadequate livelihood assets and opportunities. We examine the
extent to which various livelihood strategies lessened vulnerability post-Typhoon Yolanda
and argue that creating conditions under which disaster survivors have the freedom to pursue sustainable livelihood is essential in order to foster resilience and reduce vulnerability against future disasters. We offer suggestions to improve future relief efforts, including
suggestions made by the survivors themselves. We caution against rehabilitation strategies
that knowingly or unknowingly, resurrect pre-disaster vulnerability. Strategies that foster
dependency, fail to appreciate local political or ecological conditions or undermine cooperation and cohesion in already vulnerable communities will be bound to fail. Some of the
livelihood strategies that we observed post-Typhoon Yolanda failed on some or all of these
points. It is important for future policy that these failings are addressed
Consequences of the size structure of fish populations for their effects on a generalist avian predator
Size-structured interspecific interactions can shift between predation and competition, depending on ontogenetic changes in size relationships. I examined the effects of common carp (Cyprinus carpio), an omnivorous fish, on the reproductive success of the red-necked grebe (Podiceps grisegena), an avian gape-limited predator, along a fish size gradient created by stocking distinct age-cohorts in seminatural ponds. Young-of-the-year (0+) carp were an essential food source for young grebes. Only adult birds were able to consume 1-year-old (1+) fish, while 2-year-old (2+) fish attained a size refuge from grebes. Amphibian larvae were the principal alternative prey to fish, followed by macroinvertebrates, but the abundance of both dramatically decreased along the carp size gradient. Fledging success was 2.8 times greater in ponds with 0+ versus 1+ carp; in ponds with 1+ carp, chicks received on average 2.6–3 times less prey biomass from their parents, and over 1/3 of broods suffered total failure. Breeding birds avoided settling on 2+ ponds. These results show that changes in prey fish size structure can account for shifts from positive trophic effects on the avian predator to a negative impact on the predator’s alternative resources. However, competition did not fully explain the decrease in grebe food resources in the presence of large fish, as carp and grebes overlapped little in diet. In experimental cages, 1+ carp totally eliminated young larvae of amphibians palatable to fish. In field conditions, breeding adults of palatable taxa avoided ponds with 1+ and older carp. Non-trophic interactions such as habitat selection by amphibians or macroinvertebrates to avoid large fish may provide an indirect mechanism strengthening the adverse bottom-up effects of fish on birds
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