14 research outputs found
Tissue-specific differences of the mitochondrial protein import machinery: in vitro import, processing and degradation of the pre-F1? subunit of the ATP synthase in spinach leaf and root mitochondria
No full textA novel TAT–Mitochondrial signal sequence fusion protein is processed, stays in mitochondria, and crosses the placenta
No full textThe yeast protein Mrs6p, a homologue of the rabGDI and human choroideraemia proteins, affects cytoplasmic and mitochondrial functions
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Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization
No full textAn increasing number of mitochondrial preproteins are sequentially processed upon import by the presequence mitochondrial processing peptidase (MPP) and the intermediate peptidase octapeptidyl aminopeptidase 1 (Oct1). We show that Oct1 removes destabilizing residues from import intermediates generated by MPP. Oct1 therefore acts as a quality control system, preventing premature substrate degradation
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
No full textDysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast
No full textLON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins
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