Validity and Qualitative Research: An Oxymoron?

qualitative research, legitimation, validity, criteria, standards, rigor, accountability,

Overview of Solar Wind–Magnetosphere–Ionosphere–Atmosphere Coupling and the Generation of Magnetospheric Currents

We review the morphology and dynamics of the electrical current systems of the terrestrial magnetosphere and ionosphere. Observations from the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE) over the three years 2010 to 2012 are employed to illustrate the variability of the field-aligned currents that couple the magnetosphere and ionosphere, on timescales from minutes to years, in response to the impact of solar wind disturbances on the magnetosphere and changes in the level of solar illumination of the polar ionospheres. The variability is discussed within the context of the occurrence of magnetic reconnection between the solar wind and terrestrial magnetic fields at the magnetopause, the transport of magnetic flux within the magnetosphere, and the onset of magnetic reconnection in the magnetotail. The conditions under which the currents are expected to be weak, and hence minimally contaminate measurements of the internally-produced magnetic field of the Earth, are briefly outlined

Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis. Methods RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged 18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms. Discussion RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options. Registration NCT05172024. Copyright: © 2023 Horwitz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]