Reinstated episodic context guides sampling-based decisions for reward.

How does experience inform decisions? In episodic sampling, decisions are guided by a few episodic memories of past choices. This process can yield choice patterns similar to model-free reinforcement learning; however, samples can vary from trial to trial, causing decisions to vary. Here we show that context retrieved during episodic sampling can cause choice behavior to deviate sharply from the predictions of reinforcement learning. Specifically, we show that, when a given memory is sampled, choices (in the present) are influenced by the properties of other decisions made in the same context as the sampled event. This effect is mediated by fMRI measures of context retrieval on each trial, suggesting a mechanism whereby cues trigger retrieval of context, which then triggers retrieval of other decisions from that context. This result establishes a new avenue by which experience can guide choice and, as such, has broad implications for the study of decisions

Re-integerization of fractional charges in the correlated quarter-filled band

Previous work has demonstrated the existence of soliton defect states with charges +/- e/2 in the limits of zero and of infinite on-site Coulomb interactions in the one-dimensional (1D) quarter-filled band. For large but finite on-site Coulomb interaction, the low temperature 2k_F bond distortion that occurs within the 4k_F bond-distorted phase is accompanied by charge-ordering on the sites. We show that a ``re-integerization'' of the defect charge occurs in this bond-charge density wave (BCDW) state due to a ``binding'' of the fractional charges. We indicate briefly possible implications of this result for mechanisms of organic superconductivity.Comment: 4 eps figure

Chemical Composition of Faint (I~21 mag) Microlensed Bulge Dwarf OGLE-2007-BLG-514S

We present a high-resolution spectrum of a microlensed G dwarf in the Galactic bulge with spectroscopic temperature T_eff = 5600 +/- 180 K. This I~21 mag star was magnified by a factor ranging from 1160 to 1300 at the time of observation. Its high metallicity ([Fe/H] = 0.33 +/- 0.15) places this star at the upper end of the bulge giant metallicity distribution. Using a K-S test, we find a 1.6% probability that the published microlensed bulge dwarfs share an underlying distribution with bulge giants, properly accounting for a radial bulge metallicity gradient. We obtain abundance measurements for 15 elements and perform a rigorous error analysis that includes covariances between parameters. This star, like bulge giants with the same metallicity, shows no alpha enhancement. It confirms the chemical abundance trends observed in previously analyzed bulge dwarfs. At supersolar metallicities, we observe a discrepancy between bulge giant and bulge dwarf Na abundances.Comment: 13 pages, 8 figures, 5 tables, submitted to Ap

Recoil Corrections of Order (Zα)6(m/M)m(Z\alpha)^6(m/M)m to the Hydrogen Energy Levels Revisited

The recoil correction of order $(Z\alpha)^6(m/M)m$ to the hydrogen energy levels is recalculated and a discrepancy existing in the literature on this correction for the 1S energy level, is resolved. An analytic expression for the correction to the S-levels with arbitrary principal quantum number is obtained.Comment: 17 pages, ReVTe

Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development

Easily accessible normal tissues expressing the same molecular site(s) of drug action as malignant tissue offer an enhanced potential for early proof of anticancer drug mechanism and estimation of the biologically effective dose. Studies were undertaken in healthy male volunteers to assess the tolerability of single and multiple (four in 24 h) 3 mm punch biopsies of the buccal mucosa, and to determine the feasibility of detecting and quantifying a range of proliferation, cell-cycle arrest and apoptosis markers by immunohistochemistry (IHC) for use as potential pharmacodynamic (PD) end points. The biopsy procedure was well tolerated with 100% of volunteers stating that they would undergo single (n=10) and multiple (n=12) biopsies again. Total retinoblastoma protein (pRb), phosphorylated pRb (phospho-pRb), total p27, phosphorylated p27 (phospho-p27), phosphorylated-histone H3 (phospho-HH3), p21, p53, Cyclin A, Cyclin E, Ki67 all produced good signal detection, but M30, cleaved caspase 3 and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling did not. Total pRb, phospho-pRb, total p27 and phospho-p27 were quantified further in a multiple biopsy study to allow components of variability to be addressed to inform future sizing decisions on intervention studies. Neither site of biopsy within the oral cavity, nor the nominal time of biopsy had any significant impact on any of the four markers expression levels. Inter- and intrasubject coefficients of variation (CVs) that could be used to size future intervention studies for pRb, phospho-pRb, total p27 and phospho-p27 were 14, 19, 18 and 16%; and 18, 29, 25 and 19%, respectively. In conclusion, quantitation of such markers in 3 mm buccal punch biopsies would be suitable to explore as PD end points within intervention studies of drugs acting on these pathways

Effects of two contrasting canopy manipulations on growth and water use of London plane (Platanus x acerifolia) trees

Aims: Two contrasting canopy manipulations were compared to unpruned controls on London plane trees, to determine the effects on canopy regrowth, soil and leaf water relations. Methods: ‘Canopy reduction’, was achieved by removing the outer 30 % length of all major branches and ‘canopy thinning’, by removing 30 % of lateral branches arising from major branches. Results: Total canopy leaf areas recovered within two and three years of pruning for the canopy-thinned and reduced trees respectively. Canopy reduction increased mean leaf size, nitrogen concentration, canopy leaf area density and conserved soil moisture for up to 3 years, whereas canopy thinning had no effects. Another experiment compared more severe canopy reduction to unpruned trees. This produced a similar growth response to the previous experiment, but soil moisture was conserved nearer to the trunk. Analysis of 13C and 18O signals along with leaf water relations and soil moisture data suggested that lower boundary layer conductance within the canopy-reduced trees restricted tree water use, whereas for the canopy-thinned trees the opposite occurred. Conclusions: Only canopy reduction conserved soil moisture and this was due to a combination of reduced total canopy leaf area and structural changes in canopy architecture