670 research outputs found
State-of-the-Science Workshop Report: Issues and Approaches in Low-Dose–Response Extrapolation for Environmental Health Risk Assessment
Low-dose extrapolation model selection for evaluating the health effects of environmental pollutants is a key component of the risk assessment process. At a workshop held in Baltimore, Maryland, on 23–24 April 2007, sponsored by U.S. Environmental Protection Agency and Johns Hopkins Risk Sciences and Public Policy Institute, a multidisciplinary group of experts reviewed the state of the science regarding low-dose extrapolation modeling and its application in environmental health risk assessments. Participants identified discussion topics based on a literature review, which included examples for which human responses to ambient exposures have been extensively characterized for cancer and/or noncancer outcomes. Topics included the need for formalized approaches and criteria to assess the evidence for mode of action (MOA), the use of human versus animal data, the use of MOA information in biologically based models, and the implications of interindividual variability, background disease processes, and background exposures in threshold versus nonthreshold model choice. Participants recommended approaches that differ from current practice for extrapolating high-dose animal data to low-dose human exposures, including categorical approaches for integrating information on MOA, statistical approaches such as model averaging, and inference-based models that explicitly consider uncertainty and interindividual variability
Changes in Pest Infestation Levels, Self-Reported Pesticide Use, and Permethrin Exposure during Pregnancy after the 2000–2001 U.S. Environmental Protection Agency Restriction of Organophosphates
Para Niños Saludables: A Community Intervention Trial to Reduce Organophosphate Pesticide Exposure in Children of Farmworkers
A General Approach to Test for Interaction Among Mixtures of Insecticidal Proteins Which Target Different Orders of Insect Pests
Short-Term Effects of PM10 and NO2 on Respiratory Health among Children with Asthma or Asthma-like Symptoms: A Systematic Review and Meta-Analysis
Gas Dynamic Virtual Nozzle for Generation of Microscopic Droplet Streams
As shown by Ganan-Calvo and co-workers, a free liquid jet can be compressed
in iameter through gas-dynamic forces exerted by a co-flowing gas, obviating
the need for a solid nozzle to form a microscopic liquid jet and thereby
alleviating the clogging problems that plague conventional droplet sources of
small diameter. We describe in this paper a novel form of droplet beam source
based on this principle. The source is miniature, robust, dependable, easily
fabricated, and eminently suitable for delivery of microscopic liquid droplets,
including hydrated biological samples, into vacuum for analysis using vacuum
instrumentation. Monodisperse, single file droplet streams are generated by
triggering the device with a piezoelectric actuator. The device is essentially
immune to clogging
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Does the source migration pathway of HBCDs to household dust influence their bioaccessibility?
A study was conducted to assess the human bioaccessibility of dust contaminated with hexabromocyclododecane (HBCD) via two migration pathways a) volatilisation with subsequent partitioning to dust particles, and b) abrasion of treated textile fibres directly to the dust. This was achieved using previously developed experimental chamber designs to generate dust samples contaminated with HBCDs emit-ted from a HBCD treated textile curtain. The generated dust samples were exposed to an in vitro colon extended physiologically based extraction test (CE-PBET). The bioaccessibility of the HBCDs which were incorporated within dust as a result of volatilisation from the curtain material with subsequent partitioning to dust was higher than in dusts contaminated with HBCDs via abrasion of the curtain (35% and 15% respectively). We propose this occurs due to a stronger binding of HBCDs to treated fabric fibres than that experienced following volatilisation and sorption of HBCDs to dust particles
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