Evidence of instability in previously-mapped landslides as measured using GPS, optical, and SAR data between 2007 and 2017: A case study in the Portuguese Bend Landslide Complex, California

Velocity dictates the destructive potential of a landslide. A combination of synthetic aperture radar (SAR), optical, and GPS data were used to maximize spatial and temporal coverage to monitor continuously-moving portions of the Portuguese Bend landslide complex on the Palos Verdes Peninsula in Southern California. Forty SAR images from the COSMO-SkyMed satellite, acquired between 19 July 2012 and 27 September 2014, were processed using Persistent Scatterer Interferometry (PSI). Eight optical images from the WorldView-2 satellite, acquired between 20 February 2011 and 16 February 2016, were processed using the Co-registration of Optically Sensed Images and Correlation (COSI-Corr) technique. Displacement measurements were taken at GPS monuments between September 2007 and May 2017. Incremental and average deformations across the landslide complex were measured using all three techniques. Velocity measured within the landslide complex ranges from slow (\u3e 1.6 m/year) to extremely slow (\u3c 16 mm/year). COSI-Corr and GPS provide detailed coverage of m/year-scale deformation while PSI can measure extremely slow deformation rates (mm/year-scale), which COSI-Corr and GPS cannot do reliably. This case study demonstrates the applicability of SAR, optical, and GPS data synthesis as a complimentary approach to repeat field monitoring and mapping to changes in landslide activity through time

Building the Foundation for a Necessary Debate: Projectification of Society

Projectification is the phenomenon whereby activities traditionally carried out in a functional manner are approached as projects. It also includes the transformation processes of organisations as project management and non-functional structures. It is a phenomenon that has become important in recent years. It has brought great benefits to organisations and public administration, and it has optimised the use of economic resources. On the other hand, projectification also brings undesirable effects, known as the dark side of projectification. Several years after the first time projectification was coined, a deep debate about projectification has been necessary to make the most of all possible levels. This research, through a bibliometric analysis and a review of the most outstanding literature, identifies those aspects that need to be discussed and where there is room for improvement. The results, with an important set of disadvantages of projectification, sometimes not taken into account, especially at the individual level, establish a solid basis for the debate on projectification and the possible points of improvement from all perspectives (individual, organisational and societal). These perspectives should be observed as different but complementary, forming a holistic understanding of projectification

The 12th “Iter Mediterraneum” in Tunisia, 24 March – 4 April 2014

The organization and logistics of the 12th OPTIMA Iter in Tunisia from 24 March to 4 April 2014 by OPTIMA and ATUTAX is here reported. The material used and the workflow are illustrated as reference for the organization of future similar collaborative botanical excursions

Informe técnico : volcán de Fuego

Estudio realizado entre los meses de agosto y septiembre de 2018Bibliografía: p. 165-169Estudio en el marco de las actividades de respuesta humanitaria proporcionadas a las personas damnificadas por la erupción del Volcán de Fuego en el Departamento de Escuintla (Guatemala).Este estudio se ha llevado a cabo con el apoyo de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID), y forma parte de las actividades de respuesta humanitaria proporcionadas a los damnificados por la erupción del Volcán de Fuego en el Departamento de Escuintla (Guatemala), en el marco del Convenio AECID 14-CO1-216

Tekoporã

Asunción (abril 2013): el mes dedicado a los Pueblos Indígenas estuvo centrado en torno a dos actividades principales: la exposición “Tekoporã”, curada por Ticio Escobar que se inauguró el viernes 12 de abril de 2013, y el seminario “Los mundos posibles”, que se desarrolló a lo largo de inco semanas, con una serie de producciones audiovisuales, que contaron con la presencia de los realizadores y algunos de los protagonistas, y con una serie de sesiones teóricas con algunos de los mayores especialistas en la materia

Effects of High-Mobility Group A Protein Application on Canine Adipose-Derived Mesenchymal Stem Cells In Vitro

Multipotency and self-renewal are considered as most important features of stem cells to persist throughout life in tissues. In this context, the role of HMGA proteins to influence proliferation of adipose-derived mesenchymal stem cell (ASCs) while maintaining their multipotent and self-renewal capacities has not yet been investigated. Therefore, extracellular HMGA1 and HMGA2 application alone (10–200 ng/mL) and in combination with each other (100, 200 ng/mL each) was investigated with regard to proliferative effects on canine ASCs (cASCs) after 48 hours of cultivation. Furthermore, mRNA expression of multipotency marker genes in unstimulated and HMGA2-stimulated cASCs (50, 100 ng/mL) was analyzed by RT-qPCR. HMGA1 significantly reduced cASCs proliferation in concentrations of 10–200 ng/mL culture medium. A combination of HMGA1 and HMGA2 protein (100 and 200 ng/mL each) caused the same effects, whereas no significant effect on cASCs proliferation was shown after HMGA2 protein application alone. RT-qPCR results showed that expression levels of marker genes including KLF4, SOX2, OCT4, HMGA2, and cMYC mRNAs were on the same level in both HMGA2-protein-stimulated and -unstimulated cASCs. Extracellular HMGA protein application might be valuable to control proliferation of cASCs in context with their employment in regenerative approaches without affecting their self-renewal and multipotency abilities

Plk1 overexpression induces chromosomal instability and suppresses tumor development

Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene and an attractive cancer target. However, its contribution to tumor development is unclear. Using a new inducible knock-in mouse model we report here that Plk1 overexpression results in abnormal chromosome segregation and cytokinesis, generating polyploid cells with reduced proliferative potential. Mechanistically, these cytokinesis defects correlate with defective loading of Cep55 and ESCRT complexes to the abscission bridge, in a Plk1 kinase-dependent manner. In vivo, Plk1 overexpression prevents the development of Kras-induced and Her2-induced mammary gland tumors, in the presence of increased rates of chromosome instability. In patients, Plk1 overexpression correlates with improved survival in specific breast cancer subtypes. Therefore, despite the therapeutic benefits of inhibiting Plk1 due to its essential role in tumor cell cycles, Plk1 overexpression has tumor-suppressive properties by perturbing mitotic progression and cytokinesis.We are indebted to Stephen Taylor for the Sgo1 antibody. We thank Simone Kraut, Jessica Steiner, and the DKFZ light microscopy unit for excellent technical assistance. The results published here are in part based on data generated by TCGA pilot project (https://cancergenome.nih.gov/established by the NCI and the National Human Gen- ome Research Institute. The data were retrieved through dbGaP authorization (accession no. phs000178.v9.p8). S.V.V. was supported by the Marie Curie Network Ploidynet, funded by the European Union Seventh Framework Programme (FP7/2007–2013) under Grant Agreement #316964. L.S. is supported by a postdoctoral fellowship from Funda- cion Ramon Areces. Work in the R.S. laboratory was supported by an ERC starting grant (#281614), Marie Curie PCIG09-GA-2011 –293745 and the Howard Hughes Medical Institute. G.d.C. is funded by AECC Scientific Foundation (LABAE16017DECA). Work in the M.M. laboratory was supported by grants from the MINECO (SAF2015 –69920-R cofunded by ERDF-EU), Worldwide Cancer Research (WCR no. 150278), and Comunidad de Madrid (iLUNG-CM; B2017/BMD3884). The CNIO is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0510).S

Mesenchymal Stem Cells and Extracellular Vesicles: An Emerging Alternative to Combat COVID-19

The global SARS-CoV-2 outbreak has been accompanied with severe socio-economic and health burdens that will ripple through history. It is now known that SARS-CoV-2 induces a cytokine storm that leads to acute respiratory distress syndrome and systemic organ damage. With no definitive nor safe therapy for COVID-19 as well as the rise of viral variants the need for an urgent treatment modality is paramount. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have long been praised for their anti-viral, anti-inflammatory and tissue regenerative capabilities. MSCs and their EVs are now being studied for their possible use as a treatment modality for COVID-19. In this review we explore their capabilities and outline the evidence of their use in ALI, ARDS and COVID-19

Plastid phylogenomics resolves ambiguous relationships within the orchid family and provides a solid timeframe for biogeography and macroevolution

Recent phylogenomic analyses based on the maternally inherited plastid organelle have enlightened evolutionary relationships between the subfamilies of Orchidaceae and most of the tribes. However, uncertainty remains within several subtribes and genera for which phylogenetic relationships have not ever been tested in a phylogenomic context. To address these knowledge-gaps, we here provide the most extensively sampled analysis of the orchid family to date, based on 78 plastid coding genes representing 264 species, 117 genera, 18 tribes and 28 subtribes. Divergence times are also provided as inferred from strict and relaxed molecular clocks and birth–death tree models. Our taxon sampling includes 51 newly sequenced plastid genomes produced by a genome skimming approach. We focus our sampling efforts on previously unplaced clades within tribes Cymbidieae and Epidendreae. Our results confirmed phylogenetic relationships in Orchidaceae as recovered in previous studies, most of which were recovered with maximum support (209 of the 262 tree branches). We provide for the first time a clear phylogenetic placement for Codonorchideae within subfamily Orchidoideae, and Podochilieae and Collabieae within subfamily Epidendroideae. We also identify relationships that have been persistently problematic across multiple studies, regardless of the different details of sampling and genomic datasets used for phylogenetic reconstructions. Our study provides an expanded, robust temporal phylogenomic framework of the Orchidaceae that paves the way for biogeographical and macroevolutionary studies.Universidad de Costa Rica/[814-B8-257]/UCR/Costa RicaUniversidad de Costa Rica/[814-B6-140]/UCR/Costa RicaIDEA WILD/[]//Estados UnidosSociedad Colombiana de Orquideología/[]/SCO/ColombiaFundação de Amparo à Pesquisa do Estado de São Paulo/[11/08308-9]/FAPESP/BrasilFundação de Amparo à Pesquisa do Estado de São Paulo/[13/19124-1]/FAPESP/BrasilSwiss Orchid Foundation/[]//SuizaRoyal Botanic Gardens, Kew/[]//InglaterraSwedish Research Council/[2019-05191]//SueciaSwedish Foundation for Strategic Research/[FFL15-0196]/SSF/SueciaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Jardín Botánico Lankester (JBL