Radio Science Investigation on a Mercury Orbiter Mission

We review the results from {\it Mariner 10} regarding Mercury's gravity field and the results from radar ranging regarding topography. We discuss the implications of improving these results, including a determination of the polar component, as well as the opportunity to perform relativistic gravity tests with a future {\it Mercury Orbiter}. With a spacecraft placed in orbit with periherm at 400 km altitude, apherm at 16,800 km, period 13.45 hr and latitude of periherm at +30 deg, one can expect a significant improvement in our knowledge of Mercury's gravity field and geophysical properties. The 2000 Plus mission that evolved during the European Space Agency (ESA) {\it Mercury Orbiter} assessment study can provide a global gravity field complete through the 25th degree and order in spherical harmonics. If after completion of the main mission, the periherm could be lowered to 200 km altitude, the gravity field could be extended to 50th degree and order. We discuss the possibility that a search for a Hermean ionosphere could be performed during the mission phases featuring Earth occultations. Because of its relatively large eccentricity and close proximity to the Sun, Mercury's orbital motion provides one of the best solar-system tests of general relativity. Consequently, we emphasize the number of feasible relativistic gravity tests that can be performed within the context of the parameterized post-Newtonian formalism - a useful framework for testing modern gravitational theories. We pointed out that current results on relativistic precession of Mercury's perihelion are uncertain by 0.5 %, and we discuss the expected improvement using {\it Mercury Orbiter}. We discuss the importance of {\it Mercury Orbiter} for setting limits on a possible time variation in theComment: 23 pages, LaTeX, no figure

Search for the associated production of the Higgs boson with a top-quark pair

A search for the standard model Higgs boson produced in association with a top-quark pair t t ¯ H (tt¯H) is presented, using data samples corresponding to integrated luminosities of up to 5.1 fb −1 and 19.7 fb −1 collected in pp collisions at center-of-mass energies of 7 TeV and 8 TeV respectively. The search is based on the following signatures of the Higgs boson decay: H → hadrons, H → photons, and H → leptons. The results are characterized by an observed t t ¯ H tt¯H signal strength relative to the standard model cross section, μ = σ/σ SM ,under the assumption that the Higgs boson decays as expected in the standard model. The best fit value is μ = 2.8 ± 1.0 for a Higgs boson mass of 125.6 GeV

Measurement of prompt Jψ\psi pair production in pp collisions at \sqrt s = 7 Tev

Production of prompt J/ ψ meson pairs in proton-proton collisions at s s√ = 7 TeV is measured with the CMS experiment at the LHC in a data sample corresponding to an integrated luminosity of about 4.7 fb −1 . The two J/ ψ mesons are fully reconstructed via their decays into μ + μ − pairs. This observation provides for the first time access to the high-transverse-momentum region of J/ ψ pair production where model predictions are not yet established. The total and differential cross sections are measured in a phase space defined by the individual J/ ψ transverse momentum ( p T J/ ψ ) and rapidity (| y J/ ψ |): | y J/ ψ | 6.5 GeV/ c ; 1.2 4.5 GeV/ c . The total cross section, assuming unpolarized prompt J/ ψ pair production is 1.49 ± 0.07 (stat) ±0.13 (syst) nb. Different assumptions about the J/ ψ polarization imply modifications to the cross section ranging from −31% to +27%

Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study

Background The association of fitness with cancer risk is not clear. Methods We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method. Results After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min−1⋅kg−1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73–0.89), colorectal (0.94, 0.90–0.99), and breast cancer (0.96, 0.92–0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min−1⋅kg−1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86–0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated. Discussion Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes in body composition, may be an effective strategy for cancer prevention

Complex stamp forming of advanced thermoplastic composites

The inherent advantages of thermoplastics over the traditional thermoset composite systems are well recognized in the aeronautics community. The main advantages are the much faster processing and the higher toughness. The current advanced thermoplastic material systems provide excellent mechanical performance but their main disadvantage is the difficult processing. Ideally, future aircraft subcomponents with complex shapes can be readily formed on the basis of pre-consolidated tailored laminates based on uni-directional plies. However, to exploit the full potential of thermoplastic composites models are to be developed in order to predict the process feasibility and product performance in an early stage of development. This paper addresses a number of steps to increase the accuracy of stamp forming simulations and highlights promising results for identifying intra-ply shear and tool-ply behavior of thermoplastic composites. A comparison of the forming behavior of a doubly curved reference part with simulations will be presented. The paper concludes with remarks on necessary future research

Hyperbaric oxygen therapy for local late radiation toxicity in breast cancer patients: A systematic review.

PURPOSE: This systematic review aims to provide an overview of the literature on the effect of hyperbaric oxygen therapy (HBOT) on symptoms of local late radiation toxicity (LRT) in patients treated for breast cancer. METHODS: A systematic search was performed in September 2021. All studies with a sample size of ≥10 patients reporting the effect of HBOT for symptoms of LRT after radiotherapy of the breast and/or chest wall were included. The ROBINS-I tool was used for critical appraisal of methodological quality. The toxicity outcomes pain, fibrosis, lymphedema, necrosis/skin problems, arm and shoulder mobility, and breast and arm symptoms were evaluated. RESULTS: Nine studies concerning a total of 1308 patients were included in this review. Except for one study, sample sizes were small. Most studies had inadequate methodology with a substantial risk of bias. Post-HBOT, a significant reduction of pain was observed in 4/5 studies, of fibrosis in 1/2 studies, and of lymphedema of the breast and/or arm in 4/7 studies. Skin problems of the breast were significantly reduced in 1/2 studies, arm- and shoulder mobility significantly improved in 2/2 studies, and breast- and arm symptoms were significantly reduced in one study. CONCLUSION: This systematic review indicates that HBOT might be useful for reducing symptoms of LRT in breast cancer patients, however evidence is limited. A randomized controlled trial in a larger cohort of patients including a combination of patient- and clinician-reported outcome measures would be valuable to assess the effect of HBOT on symptoms of LRT