15 research outputs found
RELEVANCE OF SECONDARY PROCESSES IN ORAC VALUES OBTAINED EMPLOYING PYROGALLOL RED AS TARGET MOLECULE
Effect of the monomer hydrophobicity on the microemulsion polymerization.: A comparison of the efficiency of water- and oil-soluble photoinitiators
Development of New Potential Anticancer Metal Complexes Derived from 2-Hydrazinobenzothiazole
Interference of Ninhydrin Pretreatment on Leuco Crystal Violet Visualization of Bloodstains
Purification and characterization of a 6.5 kDa antioxidant peptidoglycan purified from silk worm (Bombyx mori) pupae extract
Method for Evaluation of the Antioxidant Properties of Preparations in Model System Based on Paprika Carotenoids
The antioxidant activities of seasonings used in Asian cooking. Powerful antioxidant activity of dark soy sauce revealed using the ABTS assay
Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution
This study evaluated the association of N-hexyl-2-methyl-4-nitroimidazol, a model drug, to aggregates formed by anionic polyelectrolytes on aqueous solution. The alternating copolymers of maleic anhydride and N-vinyl-2-pyrrolidone were synthesized and then modified by reaction of the anhydride groups with aliphatic amines and alcohols of varying length of the alkyl chain. The partition of the model drug between water and the hydrophobic microdomains provided by the copolymers was studied using the pseudo-phase model to determinate the distribution coefficient K S, and the standard free energy of transfer ∆”°t. The results indicate that all copolymers assessed are potential pharmaceutical reservoirs of the model drug. Nevertheless, the solubility of N-hexyl-2-methyl-4-nitroimidazol on the polymeric solutions is independent from the length of the alkyl chain of the copolymer