Банковская деятельность в условиях пандемии: от традиционного обслуживания к необанкам

В статье исследуются преимущества и недостатки широкого перенесения банковских услуг, в период кризисных явлений, в онлайн-среду с переходом к использованию услуг необанков

Управление финансами организации в условиях современной экономики

В статье рассматриваются вопросы анализа организации финансового менеджмента на предприятии, совершенствования системы финансового менеджмента, а также проблемы управления финансами организации в современных экономических условиях

Особенности управления кадровым составом банковской организации

К особенностям кадрового планирования в рамках управления персоналом приводят отличия в составляющих кадрового потенциала (квалификации, профессиональной мотивации, профессионально важных качествах) работников определенной профессиональной специализации и особенности складывающейся в организации кадровой ситуации. В свою очередь данные особенности возникают из отличий в содержании профессиональной деятельности в разных сферах и положения организации на рынке. В данной статье рассмотрены особенности управления кадровым составом банковской организации

Advanced method for sea ice concentration retrieval from satellite microwave radiometer measurements at frequencies near 90 GHz

An advanced method for sea ice concentration retrieval from satellite microwave radiometer measurements at frequencies near 90 GHz is presented. The method is based on the new approach for the determination of the tie points ― the polarization differences (PD) of the brightness temperatures (TB) of the ocean-atmosphere system (PDW) and the sea ice-atmosphere system microwave radiation (PDSI). The approach is based on the results of physical modeling of the sea ice – ocean – atmosphere TB and the analysis of the measurements of the Advanced Microwave Scanning Radiometer 2 (AMSR2) in the Arctic region. The TB simulation is carried out for the whole ranges of the Arctic atmospheric conditions and sea ice and ocean parameters. The method of sea ice concentration (SIC) retrieval uses PD in measurements on the vertical and horizontal polarization at the frequency of 89 GHz and the values of tie points over the ice-free sea surface and over the sea ice. The range of PDW and PDSI variability is analyzed basing on the AMSR2 measurement data and the results of TB model calculations. The advancement of the method as compared to those traditionally used is the use of variable PDW values depending on how far from the sea ice edge is the pixel for which C is estimated. The method was tested using the maps of the Norwegian Meteorological Institute (NMI) for the Northeren, Kara and Barents seas. The error of SIC estimation, calculated using the new method, turned out to be 4.2 %, which is almost two times lower than the error of the standard product of the University of Bremen, calculated using the same verification data set

Calcium Transients and Transmitter Secretion in Different Parts of Frog Nerve Endings in Different Conditions of Calcium Ion Influx

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Experiments on frog neuromuscular preparations were performed to study the characteristics of the calcium response and the quantum secretion of acetylcholine in different pats of extended nerve terminals in different conditions of calcium influx. A calcium-sensitive fluorescent dye was used to analyze Ca2+ influx (Ca2+ transients) into the proximal and distal parts of nerve endings in conditions of increased K+ ion content, in response to blockers of N- and L-type calcium channels, and on blockade of calcium-activated potassium channels. These studies showed that at a uniform distribution density of voltage-gated calcium channels along nerve endings, the proximal-to-distal decrement in calcium transients and quantum secretion intensity persisted in conditions of additional opening of voltage-gated calcium channels by potassium depolarization, on “thinning” of these channels using specific blockers, but changed on blockade of calcium-activated potassium channels

Power flows in multi-junction power supply circuits

The article discusses a methodology that allows for an accurate calculation of the parameters of electrical equipment from the point of view of optimizing the power supply system. Taking into account the characteristics of transients processes makes it possible to select equipment in maximum load modes. Modeling of power flows caused by changes in the load of consumers is carried out on the example of calculating the power supply circuit of five junctions. It is shown that it is possible to change the direction of flows of transmitted electric power at certain ratios of parameters in individual elements of the circuit. Purpose of research: to show the possibility of changing the picture of the transmitted capacities by the elements of the power supply system, depending on consumer loads

Case of phenotype of optic nerve atrophy due to mutation in С19orf12 gene (neurodegeneration with the brain iron accumulation (nbia))

M.E. Ivanova1, V.V. Kadyshev2, D.S. Atarshchikov3, I.V. Zolnikova4, N.P. Akchurina4, N.K. Serova5, F.A. Konovalov6, E.R. Lozier6, E.A. Pomerantseva7, N.V. Vetrova7, D. Barh8, L.M. Balashova9,&nbsp;J.M. Salmasi10 1 LLC “Oftalmic”, Moscow, Russian Federation 2 Research Centre for Medical Genetics, Moscow, Russian Federation 3 Central Clinical Hospital under Presidential Affairs, Moscow, Russian Federation 4 Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation 5 N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russian Federation 6 Independent Clinical Bioinformatics Laboratory, Moscow, Russian Federation 7 Center for Genetics and Reproductive Medicine “Genetiko”, Moscow, Russian Federation 8 Institute of Integrative Omics and Applied Biotechnology (IIOAB), Bangalore, India 9 Non-profit partnership International Scientific and Practical Center for the Proliferation of Tissues of Russia, Moscow, Russian Federation 10Pirogov Russian National Research Medical University, Moscow, Russian Federation The article describes the clinical case of optic atrophy due to a homozygous mutation in exon 3 of the C19orf12 gene (chr19: 30193863AACAGCCCCCCG&gt; A, rs515726204), the frequency of which in the ExAC control sample is 0.0074. With this mutation, a frameshift occurs at 69-th position (p.Gly69fs, NM_001031726.3), which usually leads to neurodegeneration with the brain iron accumulation (NBIA), type 4 (OMIM: 614298). In described clinical case the main complaint of patient was visual impairment, with magnetic resonance imaging patient revealed only the expansion of the sellar fossa. The vision of 7-year-old boy decreased significantly for 2 years without any apparent reasons, spectacle correction did not give an improvement in vision to 100%. During the examination partial atrophy of the optic nerves was revealed, consultations were conducted with a neurologist, neurophthalmologist. Hyperreflexia, gait changes, and a slight delay in speech development were also revealed. No other clinical neurological symptoms were observed. The article describes a detailed ophthalmic clinical picture, discusses diagnostic and therapeutic tactics. Keywords: optic nerve atrophy, neurodegeneration with the brain iron accumulation, NBIA, mutation, gene, C19orf12. For citation: Ivanova M.E., Kadyshev V.V., Atarshchikov D.S. et al. Case of phenotype of optic nerve atrophy due to mutation in С19orf12 gene (neurodegeneration with the brain iron accumulation (nbia)). Russian Journal of Clinical Ophthalmology. 2020;20(1):–36. DOI: 10.32364/2311-7729-2020-20-1-33-36. </p

GENERALIZED ANALYSIS OF MONOCLONAL ANTIBODIES TO IGE IN THE TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN IN RUSSIAN FEDERATION

The article presents a generalized 2-year Russian experience in the application of monoclonal antibodies to IgE in children and adolescents with severe, resistant to standard treatment of bronchial asthma. Data on 65 patients treated with anti-IgE therapy with omalizumab within more than 6 months period in 6 centers of the Russian Federation from 2007 to 2010 were analyzed. The results of this analysis demonstrate the safety and high clinical effectiveness of anti-IgE-therapy in children and adolescents with severe uncontrolled atopic bronchial asthma. Full control of the disease or marked improvement can be achieved in 73% patients, the effect in most cases significantly increases during the first 6 months of treatment and becomes stable in the future, providing a good quality of life and normal lung function.Key words: bronchial asthma, anti-IgE-therapy, treatment, adolescents, children, quality of life, omalizumab

ОБОБЩЕННЫЙ АНАЛИЗ ПРИМЕНЕНИЯ МОНОКЛОНАЛЬНЫХ АНТИТЕЛ К IGE В ЛЕЧЕНИИ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙ В РФ

The article presents a generalized 2-year Russian experience in the application of monoclonal antibodies to IgE in children and adolescents with severe, resistant to standard treatment of bronchial asthma. Data on 65 patients treated with anti-IgE therapy with omalizumab within more than 6 months period in 6 centers of the Russian Federation from 2007 to 2010 were analyzed. The results of this analysis demonstrate the safety and high clinical effectiveness of anti-IgE-therapy in children and adolescents with severe uncontrolled atopic bronchial asthma. Full control of the disease or marked improvement can be achieved in 73% patients, the effect in most cases significantly increases during the first 6 months of treatment and becomes stable in the future, providing a good quality of life and normal lung function.Key words: bronchial asthma, anti-IgE-therapy, treatment, adolescents, children, quality of life, omalizumab.В статье представлен обобщенный 2-летний российский опыт применения моноклональных антител к IgE у детей и подростков с тяжелой, резистентной к стандартному лечению, бронхиальной астмой. Проанализированы данные 65 больных, получавших анти-IgE терапию омализумабом более 6 мес, в 6 центрах РФ с 2007 по 2010 гг. Результаты проведенного анализа свидетельствуют о безопасности и высокой клинической эффективности анти- IgE-терапии у детей и подростков с тяжелой неконтролируемой атопической бронхиальной астмой. Полного контроля болезни или выраженного улучшения удалось достичь у 73% пациентов, эффект в большинстве случаев значимо нарастает в первые 6 мес лечения и является стабильным в дальнейшем, обеспечивая хорошее качество жизни и нормальные показатели функции легких. Ключевые слова: бронхиальная астма, анти-IgE-терапия, лечение, подростки, дети, качество жизни, омализумаб. (Педиатрическая фармакология –2011; 8(2): 50-56