3 research outputs found
Properties of the VT1-0 titanium surface modified by a pulsed ion beam
The physicomechanical properties of the VT1-0 titanium surface modified by a pulsed carbon ion beam at a pulse duration of 80 ns, an energy of 200 keV, a current density of 120 A/cm2, an energy density of 1.92 J/cm2, and various numbers of pulses (four regimes) are studied. Irradiation by the beam leads to hardening of a 1.8-ΞΌm-thick surface layer in titanium, a decrease in the hydrogen sorption rate, a decrease in the grain size, and the formation of twins
Π ΠΎΠ»Ρ ΠΏΠΎΠ·ΠΈΡΡΠΎΠ½Π½ΠΎΠΉ ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ Ρ 18F-ΡΠ»ΡΠΎΡΠΎ-2-Π΄Π΅Π·ΠΎΠΊΡΠΈ-D-Π³Π»ΡΠΊΠΎΠ·ΠΎΠΉ Π² ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π΅ Π»ΠΈΠΌΡΠΎΠΌ
Β Aim. To determine the diagnostic value of positron emission tomography (PET)/computed tomography (CT) with F-18 fluorodeoxyglucose (18F-FDG) for monitoring the effectiveness and prognosis of lymphoma therapy.Materials and methods. Retrospective data of 18F-FDG PET/CT (before treatment (PET1), after two cycles (PET2), and after completion of chemotherapy (PET3)) in 30 people with lymphomas were analyzed.Results. A complete metabolic response in PET2 (PET2β) was observed in 21 patients (70%). In 9 patients in PET2β, a partial metabolic response (6 people), lack of metabolic response (2 people), or metabolic progression (1person) were detected. These patients comprised the PET2+ group.After chemotherapy, a complete metabolic response (PET3β) was diagnosed in 26 patients (87%). This effect was achieved in 21 patients (100%) with PET2β and in 5 patients (66%) with PET2+. Of the 9 patients in the PET2+ group, in 4 (44%) patients, a partial metabolic response or no metabolic response was diagnosed. Further monitoring of these patients showed that progression was diagnosed in 2 cases, and in 2 patients, further treatment resulted in complete remission. A two-year follow-up of patients revealed that remission was observed in 20 (67%) patients. The analysis of the results of PET2 showed that a relapse of the disease was observed in 6 (67%) PET2+ patients and remission was noted in 3 (33%) patients. In PET2β patients, a relapse was diagnosed in 4 (19%) persons, and remission was established in 17 (81%) patients.Conclusion. Early PET/CT with 18F-FDG allows to predict the effect ofΒ lymphoma treatment. The method can be recommended for monitoring lymphoma therapy.Β Β Π¦Π΅Π»Ρ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ ΠΏΠΎΠ·ΠΈΡΡΠΎΠ½Π½ΠΎΠΉ ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ (ΠΠΠ’/ΠΠ’) Ρ ΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠΉ 18F-ΡΠ»ΡΠΎΡΠΎ-2-Π΄Π΅Π·ΠΎΠΊΡΠΈ-D-Π³Π»ΡΠΊΠΎΠ·ΠΎΠΉΒ (18F-Π€ΠΠ) Π² ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡΒ Π»ΠΈΠΌΡΠΎΠΌ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ΡΒ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΠΠ’/ΠΠ’ Ρ 18F-Π€ΠΠ 30 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ ΡΠΎΒ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ Π»ΠΈΠΌΡΠΎΠΌΠ°ΠΌΠΈ: Π΄ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ (ΠΠΠ’1), ΡΠ΅ΡΠ΅Π·Β Π΄Π²Π° ΠΊΡΡΡΠ° (ΠΠΠ’2) ΠΈ ΠΏΠΎΡΠ»Π΅ Π·Π°Π²Π΅ΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ»ΠΈΡ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈΒ (ΠΠΠ’3).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΠΠ’2 ΠΏΠΎΠ»Π½ΡΠΉΒ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΡΠ²Π΅Ρ Π½Π° Π΄Π²Π° ΠΊΡΡΡΠ° Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ (ΠΠΠ’2β)Β Π½Π°Π±Π»ΡΠ΄Π°Π»ΡΡ Ρ 21 (70%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. Π£ 9 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ΅ΡΠ΅Π· Π΄Π²Π°Β ΡΠΈΠΊΠ»Π° Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π±ΡΠ»ΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ: ΡΠ°ΡΡΠΈΡΠ½ΡΠΉ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΡΠ²Π΅Ρ (6 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ), ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° (2 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°) ΠΈΠ»ΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ (1 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ). ΠΡΠΈ Π±ΠΎΠ»ΡΠ½ΡΠ΅ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ Π³ΡΡΠΏΠΏΡ ΠΠΠ’2+. ΠΠΎΡΠ»Π΅ ΠΎΠΊΠΎΠ½ΡΠ°Π½ΠΈΡ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠΎΠ»Π½ΡΠΉ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΡΠ²Π΅Ρ (ΠΠΠ’3β) Π±ΡΠ» Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ Ρ 26 (87%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π’Π°ΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡ Π±ΡΠ» Π΄ΠΎΡΡΠΈΠ³Π½ΡΡ Ρ 21 (100%) Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Ρ ΠΠΠ’2β ΠΈ 5 (66%) ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ Ρ ΠΠΠ’2+. ΠΠ· 9 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π³ΡΡΠΏΠΏΡ ΠΠΠ’2+ Ρ 4 (44%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΡΠ»Π΅Β Π·Π°Π²Π΅ΡΡΠ΅Π½ΠΈΡ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π±ΡΠ» Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ ΡΠ°ΡΡΠΈΡΠ½ΡΠΉ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΡΠ²Π΅Ρ ΠΈΠ»ΠΈ Π΅Π³ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅. ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅Β Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° ΡΡΠΈΠΌΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ Π² Π΄Π²ΡΡ
Β ΡΠ»ΡΡΠ°ΡΡ
Π±ΡΠ»ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅, Π° Ρ 2Β Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅Π΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈΠ²Π΅Π»ΠΎ ΠΊ ΠΏΠΎΠ»Π½ΠΎΠΉ ΡΠ΅ΠΌΠΈΡΡΠΈΠΈ. ΠΡΠΈ Π΄Π²ΡΡ
Π»Π΅ΡΠ½Π΅ΠΌ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠΈ Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΡΠ΅ΠΌΠΈΡΡΠΈΡ Π½Π°Π±Π»ΡΠ΄Π°Π»Π°ΡΡ Ρ 20 (67%)Β ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΠ½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΠΠ’2 ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ ΠΏΡΠΈ ΠΠΠ’2+ ΡΠ΅ΡΠΈΠ΄ΠΈΠ² Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π½Π°Π±Π»ΡΠ΄Π°Π»ΡΡ Π² 6 (67%) ΡΠ»ΡΡΠ°ΡΡ
, ΡΠ΅ΠΌΠΈΡΡΠΈΡ β Π² 3 (33%). Π ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ ΠΏΡΠΈ ΠΠΠ’2β ΡΠ΅ΡΠΈΠ΄ΠΈΠ²Β Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ Ρ 4 (19%) ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ, ΡΠ΅ΠΌΠΈΡΡΠΈΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Ρ 17 (81%).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΠ’/ΠΠ’ Ρ 18F-Π€ΠΠ, Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π½Π°Ρ Π½Π° ΡΠ°Π½Π½ΠΈΡ
ΡΡΠ°ΠΏΠ°Ρ
Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΠΊΠ°Π·Π°ΡΡ ΡΡΡΠ΅ΠΊΡ Π»Π΅ΡΠ΅Π½ΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠΎ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ Π»ΠΈΠΌΡΠΎΠΌΠ°ΠΌΠΈ.Β ΠΠ΅ΡΠΎΠ΄ ΠΏΠΎΠΊΠ°Π·Π°Π½ ΠΊ ΡΠΈΡΠΎΠΊΠΎΠΌΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π½Π° ΡΡΠ°ΠΏΠ°Ρ
ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΡΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ.
Properties of the VT1-0 titanium surface modified by a pulsed ion beam
The physicomechanical properties of the VT1-0 titanium surface modified by a pulsed carbon ion beam at a pulse duration of 80 ns, an energy of 200 keV, a current density of 120 A/cm2, an energy density of 1.92 J/cm2, and various numbers of pulses (four regimes) are studied. Irradiation by the beam leads to hardening of a 1.8-ΞΌm-thick surface layer in titanium, a decrease in the hydrogen sorption rate, a decrease in the grain size, and the formation of twins