Gene expression and nucleotide composition are associated with genic methylation level in Oryza sativa

Background The methylation of cytosines at CpG dinucleotides, which plays an important role in gene expression regulation, is one of the most studied epigenetic modifications. Thus far, the detection of DNA methylation has been determined mostly by experimental methods, which are not only prone to bench effects and artifacts but are also time-consuming, expensive, and cannot be easily scaled up to many samples. It is therefore useful to develop computational prediction methods for DNA methylation. Our previous studies highlighted the existence of correlations between the GC content of the third codon position (GC3), methylation, and gene expression. We thus designed a model to predict methylation in Oryza sativa based on genomic sequence features and gene expression data. Results We first derive equations to describe the relationship between gene methylation levels, GC3, expression, length, and other gene compositional features. We next assess gene compositional features involving sixmers and their association with methylation levels and other gene level properties. By applying our sixmer-based approach on rice gene expression data we show that it can accurately predict methylation (Pearson’s correlation coefficient r = 0.79) for the majority (79%) of the genes. Matlab code with our model is included. Conclusions Gene expression variation can be used as predictors of gene methylation levels

КАРЦИНОИД ЧЕРВЕОБРАЗНОГО ОТРОСТКА У ПОСТРАДАВШЕГО С ОДНОВРЕМЕННЫМИ РАНЕНИЯМИ ГРУДИ И ЖИВОТА

The article reports a clinical case of surgical therapy of a patient with simultaneous chest and abdomen trauma and carcinoid of the appendix.В статье представлено клиническое наблюдение хирургического лечения пациента с одновременными ранениями груди и живота и карциноидом червеобразного отростка

A Case of Successful Medical Treatment of Ventricular Tachycardia in a Patient With Ischemic Heart Disease and Heart Failure

The pathogenetic mechanisms of arrhythmias, including  high-grade ventricular  arrhythmias (including non-sustained ventricular  tachycardia),  in patients with coronary  heart disease may be different. Therefore, the characteristics  of ventricular arrhythmias must be considered  based on the totality of data, taking  into account all the available features. The importance  of a personalized approach  to the management of a patient with coronary  heart disease who had extensive myocardial  infarction 18.5 years ago,  followed  by mammary  coronary  artery bypass  grafting, aneurysmectomy and the development of heart failure with a low ejection fraction, in whom ventricular arrhythmias occurred against the background of a stable course of coronary disease , but after emotional stress, is reflected in this work. An extended examination, as well as a detailed study of the nature of ventricular arrhythmias, made it possible  to determine  the main provoking factor and select an individualized pathogenetic treatment with a good  antiarrhythmic result that persists for several years of observation.  Conducting mental tests and psychological questioning can be recommended for patients with coronary  heart disease  and  chronic  heart failure as an additional  examination to assess  the contribution  of the psycho-emotional factor  to arrhythmogenesis after excluding the ischemic and sympathetic  nature of ventricular ectopia. It is incorrect to consider that all ventricular arrhythmias  in patients with coronary heart disease are ischemic in nature, and in some clinical situations this statement is even erroneous

Self-Diffusion and Nuclear Magnetic Relaxation of Dendritic Macromolecules in Solutions

The self-diffusion and nuclear magnetic relaxation of poly(butylcarbosilane) and poly(allylcarbosilane) dendrimers dissolved in deuterated chloroform and poly(amidoamine) dendrimers with hydroxyl surface groups in solutions with methanol have been studied. The diffusion rates (D) have been measured by the pulsed-field-gradient nuclear magnetic resonance. It is shown that experimental concentration dependences D(φ) obtained for macromolecules in the dendrimer-solvent systems studied can be reduced to a unified view, and thus, the generalized concentration dependence of the normalized diffusion rates of dendrimers can be obtained. In the macromolecular volume concentration range from 0.01 up to 0.55, the generalized dependence of the normalized diffusion rates for dendrimers coincides with the analogous dependence for globular proteins in aqueous solutions; the last result suggests that self-diffusion features of dendrimers and globular proteins are in general similar. It is also shown that the experimental data obtained permit one to characterize the changes of the own monomer density of dendrimers depending on their molecular weight and, as a consequence, to make a conclusion about the swelling of dendritic macromolecules in the solutions studied

Theory of anyon excitons: Relation to excitons of nu=1/3 and nu=2/3 incompressible liquids

Elementary excitations of incompressible quantum liquids (IQL's) are anyons, i.e., quasiparticles carrying fractional charges and obeying fractional statistics. To find out how the properties of these quasiparticles manifest themselves in the optical spectra, we have developed the anyon exciton model (AEM) and compared the results with the finite-size data for excitons of nu=1/3 and nu=2/3 IQL's. The model considers an exciton as a neutral composite consisting of three quasielectrons and a single hole. The AEM works well when the separation between electron and hole confinement planes, h, is larger than the magnetic length l. In the framework of the AEM an exciton possesses momentum k and two internal quantum numbers, one of which can be chosen as the angular momentum, L, of the k=0 state. Existence of the internal degrees of freedom results in the multiple branch energy spectrum, crater-like electron density shape and 120 degrees density correlations for k=0 excitons, and the splitting of the electron shell into bunches for non-zero k excitons. For h larger than 2l the bottom states obey the superselection rule L=3m (m are integers starting from 2), all of them are hard core states. For h nearly 2l there is one-to-one correspondence between the low-energy spectra found for the AEM and the many- electron exciton spectra of the nu=2/3 IQL, whereas some states are absent from the many-electron spectra of the nu=1/3 IQL. We argue that this striking difference in the spectra originates from the different populational statistics of the quasielectrons of charge conjugate IQL's and show that the proper account of the statistical requirements eliminates excessive states from the spectrum. Apparently, this phenomenon is the first manifestation of the exclusion statistics in the anyon bound states.Comment: 26 pages with 9 figures, typos correcte

Theory of Photoluminescence of the ν=1\nu=1 Quantum Hall State: Excitons, Spin-Waves and Spin-Textures

We study the theory of intrinsic photoluminescence of two-dimensional electron systems in the vicinity of the $\nu=1$ quantum Hall state. We focus predominantly on the recombination of a band of initial ``excitonic states'' that are the low-lying energy states of our model at $\nu=1$. It is shown that the recombination of excitonic states can account for recent observations of the polarization-resolved spectra of a high-mobility GaAs quantum well. The asymmetric broadening of the spectral line in the $\sigma_-$ polarization is explained to be the result of the ``shake-up'' of spin-waves upon radiative recombination of excitonic states. We derive line shapes for the recombination of excitonic states in the presence of long-range disorder that compare favourably with the experimental observations. We also discuss the stabilities and recombination spectra of other (``charged'') initial states of our model. An additional high-energy line observed in experiment is shown to be consistent with the recombination of a positively-charged state. The recombination spectrum of a negatively-charged initial state, predicted by our model but not observed in the present experiments, is shown to provide a direct measure of the formation energy of the smallest ``charged spin-texture'' of the $\nu=1$ state.Comment: 23 pages, 7 postscript figures included. Revtex with epsf.tex and multicol.sty. The revised version contains slightly improved numerical results and a few additional discussions of the result

Спонтанный разрыв аневризмы желудочно-сальниковой артерии

We report a rare clinical case of spontaneous rupture of the aneurysm left gastroepiploic artery with life-threatening intra-abdominal haemorrhage.Authors declare lack of the conflicts of interests. Представлено редкое клиническое наблюдение спонтанного разрыва аневризмы левой желудочно-сальниковой артерии с жизнеугрожающим внутрибрюшным кровотечением.Авторы заявляют об отсутствии конфликта интересов

ЛЕЧЕНИЕ ПОЗДНИХ ОСЛОЖНЕНИЙ У ПАЦИЕНТА С НЕДИАГНОСТИРОВАННЫМ ЦЕРВИКОТОРАКАЛЬНЫМ РАНЕНИЕМ

Surgical treatment of cervicothoracic injuries has a special place in emergency surgery. Trauma of two anatomic regions adds some difficulties to exploration of wound and detection of all injuries. Unrevealed injuries lead to various complications, including fistulas of hollow organs.Проблема хирургического лечения цервикоторакальных ранений занимает особое место в неотложной хирургии. Ранение двух анатомических областей создает дополнительные трудности при ревизии раневого канала, выявлению всех повреждений. Недиагностированные повреждения приводят к развитию различных осложнений, в том числе к образованию свищей полых органов