Socialbots whitewashing contested elections; a case study from Honduras

We analyze socialbots active tweeting in relation to Juan Orlando Hern\'andez, the recently re-elected president of Honduras. We find a clear bimodal separation between humans and bots, using Botometer and its classifiers. Around one hundred separate communities of socialbots are identified and visualized, detected through the analysis of temporally coordinated retweets

Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides

In vitro, both carbohydrate sugars and artificial sweeteners (AS) stimulate the secretion of glucagon-like peptide-1 (GLP-1). It has been suggested that the gut tastes sugars and AS through the same mechanisms as the tongue, with potential effects on gut hormone release. We investigated whether the human gut responds in the same way to AS and carbohydrate sugars, which are perceived by lingual taste as equisweet. We focused on the secretion of gastrointestinal (GI) satiety peptides in relation to appetite perception. We performed a placebo-controlled, double-blind, six-way, cross-over trial including twelve healthy subjects. On separate days, each subject received an intragastric infusion of glucose, fructose or an AS (aspartame, acesulfame K and sucralose) dissolved in 250ml of water or water only (control). In a second part, four subjects received an intragastric infusion of the non-sweet, non-metabolisable sugar analogue 2-deoxy-d-glucose. Glucose stimulated GLP-1 (P=0·002) and peptide tyrosine tyrosine (PYY; P=0·046) secretion and reduced fasting plasma ghrelin (P=0·046), whereas fructose was less effective. Both carbohydrate sugars increased satiety and fullness (albeit not significantly) compared with water. In contrast, equisweet loads of AS did not affect gastrointestinal peptide secretion with minimal effects on appetite. 2-Deoxy-d-glucose increased hunger ratings, however, with no effects on GLP-1, PYY or ghrelin. Our data demonstrate that the secretion of GLP-1, PYY and ghrelin depends on more than the detection of (1) sweetness or (2) the structural analogy to glucos

Harnessing Large Language Models to Enhance Self-Regulated Learning via Formative Feedback

Effectively supporting students in mastering all facets of self-regulated learning is a central aim of teachers and educational researchers. Prior research could demonstrate that formative feedback is an effective way to support students during self-regulated learning (SRL). However, for formative feedback to be effective, it needs to be tailored to the learners, requiring information about their learning progress. In this work, we introduce LEAP, a novel platform that utilizes advanced large language models (LLMs), such as ChatGPT, to provide formative feedback to students. LEAP empowers teachers with the ability to effectively pre-prompt and assign tasks to the LLM, thereby stimulating students' cognitive and metacognitive processes and promoting self-regulated learning. We demonstrate that a systematic prompt design based on theoretical principles can provide a wide range of types of scaffolds to students, including sense-making, elaboration, self-explanation, partial task-solution scaffolds, as well as metacognitive and motivational scaffolds. In this way, we emphasize the critical importance of synchronizing educational technological advances with empirical research and theoretical frameworks.Comment: 9 pages, 3 Figures, 1 Tabl

Microbial vitamin production mediates dietary effects on diabetic risk

Adequate levels of essential vitamins are important for the prevention of diabetes. While the main efforts to address this are currently focused on the intake of vitamin supplements, improving and maintaining intrinsic vitamin production capacity, which is determined by gut microbes, has received insufficient attention. In this study, we systematically investigated the relationship between gut microbial vitamin production and factors related to diabetes and cardiometabolic health in a deeply phenotyped cohort, Lifelines-DEEP (N = 1,135). We found that blood glucose–related factors, lipids, circulating inflammation, and fecal short-chain fatty acids are associated with gut microbial vitamin production. Use of laxatives and metformin are associated with increased levels of vitamin B1/B6 biosynthesis pathways. We further reveal a mediatory role for microbial vitamin B1/B2 production on the influence of fruit intake on diabetes risk. This study provides preliminary evidence for microbiome-targeted vitamin metabolism interventions to promote health

Influence of radiative forcing factors on ground–air temperature coupling during the last millennium: implications for borehole climatology

Past climate variations may be uncovered via reconstruction methods that use proxy data as predictors. Among them, borehole reconstruction is a well-established technique to recover the long-term past surface air temperature (SAT) evolution. It is based on the assumption that SAT changes are strongly coupled to ground surface temperature (GST) changes and transferred to the subsurface by thermal conduction. We evaluate the SAT–GST coupling during the last millennium (LM) using simulations from the Community Earth System Model LM Ensemble (CESM-LME). The validity of such a premise is explored by analyzing the structure of the SAT–GST covariance during the LM and also by investigating the evolution of the long-term SAT–GST relationship. The multiple and single-forcing simulations in the CESM-LME are used to analyze the SAT–GST relationship within different regions and spatial scales and to derive the influence of the different forcing factors on producing feedback mechanisms that alter the energy balance at the surface. The results indicate that SAT–GST coupling is strong at global and above multi-decadal timescales in CESM-LME, although a relatively small variation in the long-term SAT–GST relationship is also represented. However, at a global scale such variation does not significantly impact the SAT–GST coupling, at local to regional scales this relationship experiences considerable long-term changes mostly after the end of the 19th century. Land use land cover changes are the main driver for locally and regionally decoupling SAT and GST, as they modify the land surface properties such as albedo, surface roughness and hydrology, which in turn modifies the energy fluxes at the surface. Snow cover feedbacks due to the influence of other external forcing are also important for corrupting the long-term SAT–GST coupling. Our findings suggest that such local and regional SAT–GST decoupling processes may represent a source of bias for SAT reconstructions from borehole measurement, since the thermal signature imprinted in the subsurface over the affected regions is not fully representative of the long-term SAT variations.Ministerio de Industria, Comercio y Competitividad (FPI grant no. BES-2015-075019)Versión del editor3,50

Controlling plasmonic hot spots by interfering Airy beams

We predict and demonstrate the generation of a plasmonic hot spot on the surface of a metal film by the interference of two Airy surface plasmons. We show that the position of the hot spot can be controlled by the distance between the excitation gratings as well as by the phase front of the initial excitation. The observed effect constitutes a planar analogy to Airy beam autofocusing and offers new opportunities for spatially resolved surface plasmon sensing and optical surface tweezers.We acknowledge support from the German Research Foundation [SPP 1391 “Ultrafast Nanooptics” and Jena School for Microbial Communication (JSMC)], the German Federal Ministry of Education and Research (PhoNa), the Thuringian Ministry of Education Science and Culture (MeMa), the Australian Research Council, the Go-8 Australia-Germany (Go8-DAAD) Joint Research Cooperation Scheme, and the Australian National Computational Infrastructure