Parkinson’s from inside out: emerging and unexpected benefits of a long-term partnership

This article is a personal reflection on a long-standing patient and public involvement (PPI) partnership between a person with Parkinson’s and a cognitive neuroscience researcher. They describe how the partnership arose, was established and evolved to produce unexpected benefits to the research and more broadly. Initially, working together helped to communicate the purpose of the research to a lay audience and to make lab-based testing sessions for people with Parkinson’s as comfortable as possible. They then worked together on the steering group for a research project about Parkinson’s and imitation, which led to co-designing interventions using imitation and imagination of movements to improve movements, including a dance class. Further benefits were realised through co-teaching undergraduate students about Parkinson’s, establishing a broader culture of PPI within the research lab and sharing their expertise of PPI more broadly. They consider key ingredients for successful collaboration, including shared curiosity, open-mindedness and trust, as well as the importance of informal discussion and space. Challenges are also considered, including authorship of research articles and anonymity. Their account demonstrates the value of the collaboration to research itself, but also the broader (often unexpected) benefits that can emerge when a collaboration has space and time to flourish

Vibrational branching ratios in photoionization of CO and N2

We report results of experimental and theoretical studies of the vibrational branching ratios for CO 4sigma(-1) photoionization from 20 to 185 eV. Comparison with results for the 2sigma(u)(-1) channel of the isoelectronic N-2 molecule shows the branching ratios for these two systems to be qualitatively different due to the underlying scattering dynamics: CO has a shape resonance at low energy but lacks a Cooper minimum at higher energies whereas the situation is reversed for N-2

Molecular photoionization as a probe of vibrational–rotational–electronic correlations

We determine the rotationally state‐resolved 2σ_u^(−1) photoionization of N_2 into alternative vibrational channels as a function of energy over a 200 eV range. Experiment and theory reveal that Cooper minima highlight the coupling between electronic, vibrational, and rotational degrees of freedom over this very wide range

Rotationally resolved photoionization: Influence of the 4σ→kσ shape resonance on CO^+ (B^2Σ^+) rotational distributions

We present experimental and theoretical results on rotational distributions of CO^+ (B^2Σ^+) photoions. Rotational distributions were determined for both the v^+=0 and v^+=1 vibrational levels following photoionization of cold (T_0≈9K) neutral CO target molecules. Data were generated using dispersed ionic fluorescence over a wide range of photoelectron kinetic energies, 0⩽E_k⩽120eV, which allows one to interrogate the ionization dynamics. This wide spectral coverage permits illustrative comparisons with theory, and calculated spectra are presented to interpret the data. In particular, the comparison between theory and experiment serves to identify the strong continuum resonant enhancement at hν_(exc)≈35eV in the l=3 partial wave of the 4σ→kσ ionization channel, as this feature has profound effects on the ion rotational distributions over a wide range of energy. Second, there are differences between the rotational substructure for the v^+=0 and v^+=1 vibrational levels. All of the experimentally observed features and trends are reproduced by theory, and the consequences of these comparisons are discussed

Psychosocial therapy for Parkinson's-related dementia: intervention development.

Background: Group-based psychosocial therapy, such as group Cognitive Stimulation Therapy, improves cognition and quality of life in people living with dementia. Neuropsychiatric symptoms and restricted mobility are common complications for people with Parkinson's-related dementia (PRD) and may limit access to, and participation in, group activities. This study describes the development of a condition-specific, home-based psychosocial therapy for people with PRD ready to be trialled in a clinical population. Methods: By means of a multistage process, a draft therapy manual was developed in an iterative manner through collaboration with medical experts, researchers and Patient and Public Involvement (PPI) representatives. In stage 1, an extensive literature search of psychosocial therapies for dementia with potential relevance for Parkinson's disease (PD) was undertaken to select a candidate therapy for adaptation. In stage 2, qualitative feedback from stakeholders and intelligence regarding existing nonpharmacological therapies for cognitive impairment in PD was combined to produce a prototype therapy manual. In stage 3, the manual was field tested in: 1) a home-setting using a 25-item assessment tool; and 2) at a local PD support group with PPI representatives. Based on the feedback from this phase, final design modifications were implemented and a draft therapy manual produced. Results: The manual was developed in an iterative manner. Interview and focus group transcripts identified three enduring themes: manual form and content, therapy acceptability by people with PRD, and companion guidance and support. Major adaptations included: removal of discrete levels of task complexity, removal of images that were potentially hallucinogenic or lacked clarity, and updating of the content. Conclusion: We have successfully developed a Cognitive Stimulation Therapy-based psychosocial therapy specifically adapted for people with PRD. The therapy is ready to trial in a pilot randomized controlled study

I feel bad and look worse than you: Social comparisons moderate the effect of mood on face health judgement

Mood can bias the judgements people make about themselves and how people compare themselves to others. However, it is not yet clear whether mood also affects appearance-based self-evaluations and social comparisons. Given the importance of perceived health status for well-being, we investigated the effect of mood on self-image and social comparisons of healthiness during two versions of a face health judgement task. Thirty participants judged how they felt compared to healthy and unhealthy looking versions of their own (self version) and a stranger’s face (stranger version), after a positive, negative and neutral mood induction. The effect of mood was dependent on self/stranger task order. Although mood did not affect face health judgement for participants who initially judged themselves against their own face, it did affect face health judgement for participants who initially judged themselves in comparison to a stranger’s face. After the positive and negative mood inductions, these participants judged themselves as equivalent to healthier/unhealthier looking versions of their own and stranger’s faces, respectively. Thus, social comparisons of facial healthiness could provide a perceptual measure of state well-being

Upper- and lower-limb amputees show reduced levels of eeriness for images of prosthetic hands

The uncanny phenomenon describes the feeling of unease associated with seeing an image which is close to appearing human. Prosthetic hands in particular are well-known to induce this effect. Little is known, however, about this phenomenon from the viewpoint of prosthesis users. We studied perceptions of eeriness and human-likeness for images of different types of mechanical, cosmetic, and anatomical hands in upper-limb prosthesis users (n=9), lower-limb prosthesis users (n=10), prosthetists (n=16), control participants with no prosthetic training (n=20), and control participants who were trained to use a myoelectric prosthetic hand simulator (n=23). Both the upper- and lowerlimb prosthesis user groups showed a reduced uncanny phenomenon (i.e., significantly lower levels of eeriness) for cosmetic prosthetic hands compared to the other groups, with no concomitant reduction in how these stimuli were rated in terms of human-likeness. However, a similar effect was found neither for prosthetists with prolonged visual experience of prosthetic hands, nor for the group with short-term training with the simulator. These findings in the prosthesis users therefore seem likely to be related to limb absence or prolonged experience with prostheses