Behind the dust curtain: the spectacular case of GRB 160623A

We report on the X-ray dust-scattering features observed around the afterglow of the gamma ray burst GRB 160623A. With an XMM-Newton observation carried out ~2 days after the burst, we found evidence of at least six rings, with angular size expanding between ~2 and 9 arcmin, as expected for X-ray scattering of the prompt GRB emission by dust clouds in our Galaxy. From the expansion rate of the rings, we measured the distances of the dust layers with extraordinary precision: 528.1 +\- 1.2 pc, 679.2 +\- 1.9 pc, 789.0 +\- 2.8 pc, 952 +\- 5 pc, 1539 +\- 20 pc and 5079 +\- 64 pc. A spectral analysis of the ring spectra, based on an appropriate dust-scattering model (BARE-GR-B from Zubko et al. 2004}) and the estimated burst fluence, allowed us to derive the column density of the individual dust layers, which are in the range 7x10^20-1.5x10^22 cm^-2. The farthest dust-layer (i.e. the one responsible for the smallest ring) is also the one with the lowest column density and it is possibly very extended, indicating a diffuse dust region. The properties derived for the six dust-layers (distance, thickness, and optical depth) are generally in good agreement with independent information on the reddening along this line of sight and on the distribution of molecular and atomic gas.Comment: 9 pages, 10 figures, 1 table; accepted for publication in MNRA

Spectral and timing properties of IGR J00291+5934 during its 2015 outburst

We report on the spectral and timing properties of the accreting millisecond X-ray pulsar IGR J00291+5934 observed by XMM-Newton and NuSTAR during its 2015 outburst. The source is in a hard state dominated at high energies by a comptonization of soft photons ($\sim0.9$ keV) by an electron population with kT$_e\sim30$ keV, and at lower energies by a blackbody component with kT$\sim0.5$ keV. A moderately broad, neutral Fe emission line and four narrow absorption lines are also found. By investigating the pulse phase evolution, we derived the best-fitting orbital solution for the 2015 outburst. Comparing the updated ephemeris with those of the previous outbursts, we set a $3\sigma$ confidence level interval $-6.6\times 10^{-13}$ s/s $< \dot{P}_{orb} < 6.5 \times 10^{-13}$ s/s on the orbital period derivative. Moreover, we investigated the pulse profile dependence on energy finding a peculiar behaviour of the pulse fractional amplitude and lags as a function of energy. We performed a phase-resolved spectroscopy showing that the blackbody component tracks remarkably well the pulse-profile, indicating that this component resides at the neutron star surface (hot-spot).Comment: 9 pages, 7 figures. Accepted for publication in MNRA

Discovery of a soft X-ray 8 mHz QPO from the accreting millisecond pulsar IGR J00291+5934

In this paper, we report on the analysis of the peculiar X-ray variability displayed by the accreting millisecond X-ray pulsar IGR J00291+5934 in a 80 ks-long joint NuSTAR and XMM-Newton observation performed during the source outburst in 2015. The light curve of the source was characterized by a flaring-like behavior, with typical rise and decay time scales of ~120 s. The flares are accompanied by a remarkable spectral variability, with the X-ray emission being generally softer at the peak of the flares. A strong quasi periodic oscillation (QPO) is detected at ~8 mHz in the power spectrum of the source and clearly associated with the flaring-like behavior. This feature has the strongest power at soft X-rays (<3 keV). We carried out a dedicated hardness-ratio resolved spectral analysis and a QPO phase-resolved spectral analysis, together with an in-depth study of the source timing properties, to investigate the origin of this behavior. We suggest that the unusual variability of IGR J00291+5934 observed by XMM-Newton and NuSTAR could be produced by an heartbeat-like mechanism, similar to that operating in black-hole X-ray binaries. The possibility that this variability, and the associated QPO, are triggered by phases of quasi-stable nuclear burning, as suggested in the literature for a number of other neutron star binaries displaying a similar behavior, cannot be solidly tested in the case of IGR J00291+5934 due to the paucity of type-I X-ray bursts observed from this source.Comment: Submitted to MNRAS on 23 Sept 2016. Modified according to the referee's suggestions. Comments are welcomed. One reference updated in this versio

Global QSAR models of skin sensitisers for regulatory purposes

Abstract Background The new European Regulation on chemical safety, REACH, (Registration, Evaluation, Authorisation and Restriction of CHemical substances), is in the process of being implemented. Many chemicals used in industry require additional testing to comply with the REACH regulations. At the same time EU member states are attempting to reduce the number of animals used in experiments under the 3 Rs policy, (refining, reducing, and replacing the use of animals in laboratory procedures). Computational techniques such as QSAR have the potential to offer an alternative for generating REACH data. The FP6 project CAESAR was aimed at developing QSAR models for 5 key toxicological endpoints of which skin sensitisation was one. Results This paper reports the development of two global QSAR models using two different computational approaches, which contribute to the hybrid model freely available online. Conclusions The QSAR models for assessing skin sensitisation have been developed and tested under stringent quality criteria to fulfil the principles laid down by the OECD. The final models, accessible from CAESAR website, offer a robust and reliable method of assessing skin sensitisation for regulatory use.</p

GRO J1744-28: an intermediate B-field pulsar in a low mass X-ray binary

The bursting pulsar, GRO J1744-28, went again in outburst after $\sim$18 years of quiescence in mid-January 2014. We studied the broad-band, persistent, X-ray spectrum using X-ray data from a XMM-Newton observation, performed almost at the peak of the outburst, and from a close INTEGRAL observation, performed 3 days later, thus covering the 1.3-70.0 keV band. The spectrum shows a complex continuum shape that cannot be modelled with standard high-mass X-ray pulsar models, nor by two-components models. We observe broadband and peaked residuals from 4 to 15 keV, and we propose a self-consistent interpretation of these residuals, assuming they are produced by cyclotron absorption features and by a moderately smeared, highly ionized, reflection component. We identify the cyclotron fundamental at $\sim$ 4.7 keV, with hints for two possible harmonics at 10.4 keV and 15.8 keV. The position of the cyclotron fundamental allows an estimate for the pulsar magnetic field of (5.27 $\pm$ 0.06) $\times$ 10$^{11}$ G, if the feature is produced at its surface. From the dynamical and relativistic smearing of the disk reflected component, we obtain a lower limit estimate for the truncated accretion disk inner radius, ($\gtrsim$ 100 R$_g$), and for the inclination angle (18$^{\circ}$-48$^{\circ}$). We also detect the presence of a softer thermal component, that we associate with the emission from an accretion disk truncated at a distance from the pulsar of 50-115 R$_g$. From these estimates, we derive the magneto-spheric radius for disk accretion to be $\sim$ 0.2 times the classical Alfv\'en radius for radial accretion.Comment: Accepted for publication in MNRA

Fibroblast proliferation and migration in wound healing by phytochemicals: Evidence for a novel synergic outcome

Wound-healing is a dynamic skin reparative process that results in a sequence of events, including inflammation, proliferation, and migration of different cell types as fibroblasts. Fibroblasts play a crucial role in repairing processes, from the late inflammatory phase until the fully final epithelization of the injured tissue. Within this context, identifying tools able to implement cell proliferation and migration could improve tissue regeneration. Recently, plants species from all over the world are coming out as novel tools for therapeutic applications thanks to their phytochemicals, which have antioxidant properties and can promote wound healing. In this paper, we aimed at investigating antioxidant activity of waste extracts from different medicinal plants, endemic of the Mediterranean area, on fibroblast proliferation and wound healing. We determined the amount of total phenols and anti-oxidant activity by ABTS assay. We then evaluated the cytotoxicity of the compounds and the proliferative capabilities of fibroblasts by scratch assay. Our results showed that waste extracts retain antioxidant and regenerative properties, inducing tissue re-establishment after environmental stress exposure. Taken together, our findings suggest that waste material could be used in the future also in combinations to stimulate wound healing processes and antioxidant responses in damaged skin

Ixodid ticks on wild donkeys in a Mediterranean nature reserve (Asinara National Park): diversity and risk factors

The Sardinian coloured donkey Equus asinus (Perissodactyla: Equidae) and its albino colour morph represent the wildlife species most typical of the island of Asinara. This Mediterranean island represents a favourable context for ticks and tick-borne diseases; however, knowledge of the tick fauna on Asinara is scarce. A total of 106 Sardinian donkeys were inspected for tick infestation from June to November 2015. All ticks found were collected, classified by stage and sex, and identified to species level. The level of infestation of each donkey was determined; both the overall tick infestation and infestations of each detected species were classified on a scale of 1\u20133 to give an infestation score (IS). Overall, 256 hard ticks were collected from 60 of 106 donkeys (56.6%). Rhipicephalus bursa, Haemaphysalis punctata and Hyalomma marginatum (all: Ixodida: Ixodidae) infested 26.4%, 28.3% and 6.6% of donkeys, respectively. Different variables affected the IS. With reference to overall tick infestation, a higher IS was observed in donkeys grazing on grassland and Mediterranean shrubland and in albino donkeys compared with coloured donkeys. The collected ticks included species involved in the transmission of pathogens to humans, which highlights the risks for public health in a tourist destination such as Asinara National Park

Study of the reflection spectrum of the accreting neutron star GX 3+1 using XMM-Newton and INTEGRAL

Broad emission features of abundant chemical elements, such as iron, are commonly seen in the X-ray spectra of accreting compact objects and their studies can provide useful information about the geometry of the accretion processes. In this work, we focus our attention on GX 3+1, a bright, persistent accreting low-mass X-ray binary, classified as an atoll source. Its spectrum is well described by an accretion disc plus a stable Comptonizing, optically thick corona which dominates the X-ray emission in the 0.3-20keV energy band. In addition, four broad emission lines are found and we associate them with reflection of hard photons from the inner regions of the accretion disc, where Doppler and relativistic effects are important. We used self-consistent reflection models to fit the spectra of the 2010 XMM-Newton observation and the stacking of the whole data sets of 2010 INTEGRAL observations. We conclude that the spectra are consistent with reflection produced at ∼10 gravitational radii by an accretion disc with an ionization parameter of ξ∼600erg cm s−1 and viewed under an inclination angle of the system of ∼35°. Furthermore, we detected for the first time for GX 3+1, the presence of a power-law component dominant at energies higher than 20keV, possibly associated with an optically thin component of non-thermal electron