2,698 research outputs found
Scaling properties of the Penna model
We investigate the scaling properties of the Penna model, which has become a
popular tool for the study of population dynamics and evolutionary problems in
recent years. We find that the model generates a normalised age distribution
for which a simple scaling rule is proposed, that is able to reproduce
qualitative features for all genome sizes.Comment: 4 pages, 4 figure
Sharp gene pool transition in a population affected by phenotype-based selective hunting
We use a microscopic model of population dynamics, a modified version of the
well known Penna model, to study some aspects of microevolution. This research
is motivated by recent reports on the effect of selective hunting on the gene
pool of bighorn sheep living in the Ram Mountain region, in Canada. Our model
finds a sharp transition in the structure of the gene pool as some threshold
for the number of animals hunted is reached.Comment: 5 pages, 4 figure
Insulinização em pacientes portadores de DM2
Essa segunda opinão formativa (SOF) sobre insulinização nos paciente portadores de Diabetes Mellitus tipo 2 tem por objetivo responder à s dúvidas mais frequentes dos médicos das equipes de saúde da famÃlia (ESF) que atuam na atenção primária de saúde (APS) no que se refere ao processo de instituição dessa terapia nos pacientes diabéticos.
A partir de um levantamento das dúvidas mais frequentes presentes nas teleconsultorias enviadas para um especialista em endocrinologia, construiu-se esse material abordando, no DM2, os objetivos e metas terapêuticas, causas do insucesso terapêutico e quando/como/porque insulinizar.
Espera-se com essa segunda opinião formativa uma capacitação e atualização dos médicos da APS no processo de insulinização do DM2, otimizando, assim, o tratamento do paciente diabético e, por consequência, minimizando as complicações advindas do mau controle desses.1.0Centro de Tecnologia em Saúde(CETES) -UFMG; Núcleo de Telessaúde da Faculdade de Medicina da UFMG
Dynamical Instability in a Trimeric Chain of Interacting Bose-Einstein Condensates
We analyze thoroughly the mean-field dynamics of a linear chain of three
coupled Bose-Einstein condensates, where both the tunneling and the
central-well relative depth are adjustable parameters. Owing to its
nonintegrability, entailing a complex dynamics with chaos occurrence, this
system is a paradigm for longer arrays whose simplicity still allows a thorough
analytical study.We identify the set of dynamics fixed points, along with the
associated proper modes, and establish their stability character depending on
the significant parameters. As an example of the remarkable operational value
of our analysis, we point out some macroscopic effects that seem viable to
experiments.Comment: 5 pages, 3 figure
A Bayesian estimate of the CMB-large-scale structure cross-correlation
Evidences for late-time acceleration of the Universe are provided by multiple
probes, such as Type Ia supernovae, the cosmic microwave background (CMB) and
large-scale structure (LSS). In this work, we focus on the integrated
Sachs--Wolfe (ISW) effect, i.e., secondary CMB fluctuations generated by
evolving gravitational potentials due to the transition between, e.g., the
matter and dark energy (DE) dominated phases. Therefore, assuming a flat
universe, DE properties can be inferred from ISW detections. We present a
Bayesian approach to compute the CMB--LSS cross-correlation signal. The method
is based on the estimate of the likelihood for measuring a combined set
consisting of a CMB temperature and a galaxy contrast maps, provided that we
have some information on the statistical properties of the fluctuations
affecting these maps. The likelihood is estimated by a sampling algorithm,
therefore avoiding the computationally demanding techniques of direct
evaluation in either pixel or harmonic space. As local tracers of the matter
distribution at large scales, we used the Two Micron All Sky Survey (2MASS)
galaxy catalog and, for the CMB temperature fluctuations, the ninth-year data
release of the Wilkinson Microwave Anisotropy Probe (WMAP9). The results show a
dominance of cosmic variance over the weak recovered signal, due mainly to the
shallowness of the catalog used, with systematics associated with the sampling
algorithm playing a secondary role as sources of uncertainty. When combined
with other complementary probes, the method presented in this paper is expected
to be a useful tool to late-time acceleration studies in cosmology.Comment: 21 pages, 15 figures, 4 tables. We extended the previous analyses
including WMAP9 Q, V and W channels, besides the ILC map. Updated to match
accepted ApJ versio
Update on the ICUD-SIU consultation on multi-parametric magnetic resonance imaging in localised prostate cancer
Introduction: Prostate cancer (PCa) imaging is a rapidly evolving field. Dramatic improvements in prostate MRI during the last decade will probably change the accuracy of diagnosis. This chapter reviews recent current evidence about MRI diagnostic performance and impact on PCa management. Materials and methods: The International Consultation on Urological Diseases nominated a committee to review the literature on prostate MRI. A search of the PubMed database was conducted to identify articles focussed on MP-MRI detection and staging protocols, reporting and scoring systems, the role of MP-MRI in diagnosing PCa prior to biopsy, in active surveillance, in focal therapy and in detecting local recurrence after treatment. Results: Differences in opinion were reported in the use of the strength of magnets [1.5 Tesla (T) vs. 3T] and coils. More agreement was found regarding the choice of pulse sequences; diffusion-weighted MRI (DW-MRI), dynamic contrast-enhanced MRI (DCE MRI), and/or MR spectroscopy imaging (MRSI) are recommended in addition to conventional T2-weighted anatomical sequences. In 2015, the Prostate Imaging Reporting and Data System (PI-RADS version 2) was described to standardize image acquisition and interpretation. MP-MRI improves detection of clinically significant PCa (csPCa) in the repeat biopsy setting or before the confirmatory biopsy in patients considering active surveillance. It is useful to guide focal treatment and to detect local recurrences after treatment. Its role in biopsy-naive patients or during the course of active surveillance remains debated. Conclusion: MP-MRI is increasingly used to improve detection of csPCa and for the selection of a suitable therapeutic approach
Recurrent high-biomass blooms of Alexandrium taylorii (Dinophyceae), a HAB species expanding in the Mediterranean.
none9openGIACOBBE M.G., PENNA A., GANGEMI E., MASO' M; GARCES E., FRAGA S., BRAVO I., AZZARO F., PENNA N.Giacobbe, M. G.; Penna, Antonella; Gangemi, E.; Maso', M; Garces, E.; Fraga, S.; Bravo, I.; Azzaro, F.; Penna, N
Cosmological constant constraints from observation-derived energy condition bounds and their application to bimetric massive gravity
Among the various possibilities to probe the theory behind the recent
accelerated expansion of the universe, the energy conditions (ECs) are of
particular interest, since it is possible to confront and constrain the many
models, including different theories of gravity, with observational data. In
this context, we use the ECs to probe any alternative theory whose extra term
acts as a cosmological constant. For this purpose, we apply a model-independent
approach to reconstruct the recent expansion of the universe. Using Type Ia
supernova, baryon acoustic oscillations and cosmic-chronometer data, we perform
a Markov Chain Monte Carlo analysis to put constraints on the effective
cosmological constant . By imposing that the cosmological
constant is the only component that possibly violates the ECs, we derive lower
and upper bounds for its value. For instance, we obtain that and within,
respectively, and confidence levels. In addition, about
30\% of the posterior distribution is incompatible with a cosmological
constant, showing that this method can potentially rule it out as a mechanism
for the accelerated expansion. We also study the consequence of these
constraints for two particular formulations of the bimetric massive gravity.
Namely, we consider the Visser's theory and the Hassan and Roses's massive
gravity by choosing a background metric such that both theories mimic General
Relativity with a cosmological constant. Using the
observational bounds along with the upper bounds on the graviton mass we obtain
constraints on the parameter spaces of both theories.Comment: 11 pages, 4 figures, 1 tabl
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