The Effect of Personal Health on the Formation of Human Capital: a Metasystem Approach

In article the problem of influence of the personality's health on formation of the human capital is considered. Authors have conducted theoretical researches of the existing knowledge of the human capital and justifications of influence of the personality's health on its formation are given. On the basis of the carried-out analysis it is established that now the personality's health is a significant factor of efficiency of any kind of activity and important quality of the personality, therefore, it can be considered as a factor of formation of the human capital. According to it need of determination of criteria, the indicators of health of the personality influencing formation and development of the human capital was designated

The effect of hydrogen on strain hardening and fracture mechanism of high-nitrogen austenitic steel

High-nitrogen austenitic steels are perspective materials for an electron-beam welding and for producing of wear-resistant coatings, which can be used for application in aggressive atmospheres. The tensile behavior and fracture mechanism of high-nitrogen austenitic steel Fe-20Cr-22Mn-1.5V-0.2C-0.6N (in wt.%) after electrochemical hydrogen charging for 2, 10 and 40 hours have been investigated. Hydrogenation of steel provides a loss of yield strength, uniform elongation and tensile strength. The degradation of tensile properties becomes stronger with increase in charging duration - it occurs more intensive in specimens hydrogenated for 40 hours as compared to ones charged for 2-10 hours. Fracture analysis reveals a hydrogen-induced formation of brittle surface layers up to 6 [mu]m thick after 40 hours of saturation. Hydrogenation changes fracture mode of steel from mixed intergranular-transgranular to mainly transgranular one

The effect of minor allele frequency on the likelihood of obtaining false positives

Determining the most promising single-nucleotide polymorphisms (SNPs) presents a challenge in genome-wide association studies, when hundreds of thousands of association tests are conducted. The power to detect genetic effects is dependent on minor allele frequency (MAF), and genome-wide association studies SNP arrays include SNPs with a wide distribution of MAFs. Therefore, it is critical to understand MAF's effect on the false positive rate

The quality of residency as necessary step in the training of specialists at the department of neurology, neurosurgery and medical genetic of USMU

In the management system,assessment of qualityof the Department of Nervous Diseases, Neurosurgery and Medical Genetics is an important part in training specialists: neurologists and neurosurgeons. In order to identify the "problem zones" of the educational process, was held an analysis of the questionnaire survey of fellows, trained in 2016-2018. The results of this survey served as the basis for the development of corrective measures aimed at improving the educational processВ системе менеджмента качества кафедры нервных болезней, нейрохирургии и медицинской генетики важный раздел занимает анализ качества постдипломного образования по подготовке специалистов: неврологов и нейрохирургов. С целью выявления «проблемных зон» учебного процесса, проведен анализ анкетирования интернов и ординаторов, проходивших обучение в 2016-2018гг. Результаты данного опроса послужили основой для разработки корректирующих мероприятий, направленных на улучшение образовательного процесса

ROLE OF TARGETED THERAPY IN THE COMBINATION TREATMENT OF PATIENTS WITH KIDNEY CANCER AND METASTATIC BRAIN INVOLVEMENT

In patients with kidney cancer (KC), the rate of metastatic brain involvement is 2-11%, is steadily growing, and is one of the important reasons for treatment failures in these patients. Surgery and radiotherapy, including radiosurgery, must be considered as optimal treatments for patients with KC and brain metastases. Systemic drug therapy has recently played a more and more increasing role in the treatment of patients with a progressive brain tumor process. At the same time, there are no exact pharmacokinetic data on drugs registered for the treatment of disseminated KC in respect to their concentration in the human central nervous when they are used in therapeutic doses. On the basis of the data of the literature review and the results of the authors’ studies, it may be concluded that while none of the target agents has still shown any significant advantage over others in treating KC patients with brain metastases. All the drugs have demonstrated their ability to achieve a clinical and X-ray verified objective effect (as stabilizations in most cases) in treating brain metastases. The most data are available on the therapeutic efficacy of sunitinib and sorafenib. In case of progressive brain tumor process, drug treatment should be individually discussed in each situation in accordance with standard approaches to treating patients with disseminated KC