Conceptualizing Enrollment Behavior: The Effect of Student Financial Aid

Traditional models of student behavior do not fully explain how students decide to enroll in any college or university. Young and Reyes sought to provide an alternative model to understand student enrollment behavior which is based on the concept of consumer choice

A multiwavlength study of PSR B0628-28: The first overluminous rotation-powered pulsar?

The ROSAT source RX J0630.8-2834 was suggested by positional coincidence to be the X-ray counterpart of the old field pulsar PSR B0628-28. This association, however, was regarded to be unlikely based on the computed energetics of the putative X-ray counterpart. In this paper we report on multiwavelength observations of PSR B0628-28 made with the ESO/NTT observatory in La Silla, the Jodrell Bank radio observatory and XMM-Newton. Although the optical observations do not detect any counterpart of RX J0630.8-2834 down to a limiting magnitude of V=26.1 mag and B=26.3 mag, XMM-Newton observations finally confirmed it to be the pulsar's X-ray counterpart by detecting X-ray pulses with the radio pulsar's spin-period. The X-ray pulse profile is characterized by a single broad peak with a second smaller peak leading the main pulse component by ~144 degree. The fraction of pulsed photons is (38 +- 7)% with no strong energy dependence in the XMM-Newton bandpass. The pulsar's X-ray spectrum is well described by a single component power law with photon index 2.63^{+0.23}_{-0.15}, indicating that the pulsar's X radiation is dominated by non-thermal emission processes. A low level contribution of thermal emission from residual cooling or from heated polar caps, cannot be excluded. The pulsar's spin-down to X-ray energy conversion efficiency is obtained to be ~16% for the radio dispersion measure inferred pulsar distance. If confirmed, PSR B0628-28 would be the first X-ray overluminous rotation-powered pulsar identified among all ~1400 radio pulsars known today.Comment: Accepted for publication in ApJ. Find a paper copy with higher resolution images at ftp://ftp.xray.mpe.mpg.de/people/web/astro-ph-0505488_rev2.pd

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray

The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in nociceptive processing in the vlPAG. It has been suggested that glutamatergic neurotransmission exerts antinociceptive effects, whereas GABAergic neurotransmission exert pronociceptive effects on pain transmission, through descending pathways. The inability to exclusively manipulate subpopulations of neurons in the PAG has prevented direct testing of this hypothesis. Here, we demonstrate the different contributions of genetically defined glutamatergic and GABAergic vlPAG neurons in nociceptive processing by employing cell type-specific chemogenetic approaches in mice. Global chemogenetic manipulation of vlPAG neuronal activity suggests that vlPAG neural circuits exert tonic suppression of nociception, consistent with previous pharmacological and electrophysiological studies. However, selective modulation of GABAergic or glutamatergic neurons demonstrates an inverse regulation of nociceptive behaviors by these cell populations. Selective chemogenetic activation of glutamatergic neurons, or inhibition of GABAergic neurons, in vlPAG suppresses nociception. In contrast, inhibition of glutamatergic neurons, or activation of GABAergic neurons, in vlPAG facilitates nociception. Our findings provide direct experimental support for a model in which excitatory and inhibitory neurons in the PAG bidirectionally modulate nociception

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid spine of hIAPP. Using the cryoEM method MicroED, we discover that one segment, 19-29 S20G, forms pairs of β-sheets mated by a dry interface that share structural features with and are similarly cytotoxic to full-length hIAPP fibrils. In contrast, a second segment, 15-25 WT, forms non-toxic labile β-sheets. These segments possess different structures and cytotoxic effects, however, both can seed full-length hIAPP, and cause hIAPP to take on the cytotoxic and structural features of that segment. These results suggest that protein segment structures represent polymorphs of their parent protein and that segment 19-29 S20G may serve as a model for the toxic spine of hIAPP

An important role for CD4 + T cells in adaptive immunity to Toxoplasma gondii in mice lacking the transcription factor Batf3

Immunity t

Honeybee Colony Vibrational Measurements to Highlight the Brood Cycle

Insect pollination is of great importance to crop production worldwide and honey bees are amongst its chief facilitators. Because of the decline of managed colonies, the use of sensor technology is growing in popularity and it is of interest to develop new methods which can more accurately and less invasively assess honey bee colony status. Our approach is to use accelerometers to measure vibrations in order to provide information on colony activity and development. The accelerometers provide amplitude and frequency information which is recorded every three minutes and analysed for night time only. Vibrational data were validated by comparison to visual inspection data, particularly the brood development. We show a strong correlation between vibrational amplitude data and the brood cycle in the vicinity of the sensor. We have further explored the minimum data that is required, when frequency information is also included, to accurately predict the current point in the brood cycle. Such a technique should enable beekeepers to reduce the frequency with which visual inspections are required, reducing the stress this places on the colony and saving the beekeeper time