The Case | Ectopic calcifications in a child

The case A nine year old boy, born of third degree consanguinity, presented with a hard left scapular swelling for 6 months. There was no history of fever, trauma or weight loss. There was no pain, redness or discharge. This mass was excised but recurred over the next 6 months (Left panel of Figure 1). A similar swelling had been excised from the left knee one year before presentation, but had recurred over 6 months. Family history was negative for similar lesions. Development was normal for age and he had no other medical problems. On examination, pulse was 84 per minute, blood pressure 96/68 mmHg, weight 22 kg and height 122 cm (both between 10th and 25th percentile). A 6 × 4 cm mass was noted in the right scapular region and a 3 × 3 cm mass at the lateral aspect of the left knee. Both of these masses were firm to hard, globular, nontender, and fixed to the bone. The overlying skin was without erythema or local warmth, though scars from the previous resections were noted. Lymphadenopathy was absent. The rest of the examination was unremarkable. Radiographs of the knee showed a lobular, inhomogenously but densely calcified lesion in the anterolateral region of the left knee (Right panel of Figure 1). Serum calcium was 9.

A Study of Chaotic Behavior of Heat Transfer In Gas-Solid Fluidized Bed

Fluidized beds are characterized by high heat transfer rates between thebed and internal surfaces and have uniform temperature distribution that can beachieved in fluidized bed systems. In the same time there is a chaotic behavior ofhydrodynamic and heat transfer in gas-solid fluidized bed.Experimental work was carried out in gas-solid (air – sand) fluidized bed toinvestigate the steady state heat transfer coefficient. The bed column used was(172) mm in diameter and (1000) mm height, fitted with immersed cylindricalheating element of (25.4) mm in diameter. The fluidizing medium was air flowingat different velocities from fixed bed to fluidized bed of (0.006-0.078)m/s, andthree different sizes of fine sand particles were used (i.e. 63, 112, and 145 μm),these average particles diameters were estimated by two methods (Wide andNarrow Range Solids).A comparison have been done with values of the minimum fluidizing velocity thatcalculated analytically, empirical, and which got experimentally. The results showa chaotic behavior of hydrodynamic gas-solid fluidized bed.The heat transfer coefficient and the bed viodage increase with increasing gasfluidizing velocity and the heat transfer coefficient decreases with an increase inparticle diameter.Two empirical correlations are proposed which can calculate wide range solids andnarrow range solids based on experimental data. The Nusselt number presentedwith some dimensionless groups as follows:-For Wide Range Solids Nu = 0.81Re0.94 Pr0.35Where the correlation coefficient (R) was equal to (0.92) and the average absoluterelative error was (12.62 %).For Narrow Range Solids Nu = 0.45Re0.65 Pr0.33Where the correlation coefficient (R) was equal to (0.86) and the average absoluterelative error was (24.2 %)

Form factors of pion and kaon

An addtional intrinsic form factors of pion and kaons have been studied.Comment: 14 pages and 10 figure

Terrestrial exposure of a fresh Martian meteorite causes rapid changes in hydrogen isotopes and water concentrations

Determining the hydrogen isotopic compositions and H2O contents of meteorites and their components is important for addressing key cosmochemical questions about the abundance and source(s) of water in planetary bodies. However, deconvolving the effects of terrestrial contamination from the indigenous hydrogen isotopic compositions of these extraterrestrial materials is not trivial, because chondrites and some achondrites show only small deviations from terrestrial values such that even minor contamination can mask the indigenous values. Here we assess the effects of terrestrial weathering and contamination on the hydrogen isotope ratios and H2O contents of meteoritic minerals through monitored terrestrial weathering of Tissint, a recent Martian fall. Our findings reveal the rapidity with which this weathering affects nominally anhydrous phases in extraterrestrial materials, which illustrates the necessity of sampling the interiors of even relatively fresh meteorite falls and underlines the importance of sample return missions

Nuclear spins, magnetic moments and quadrupole moments of Cu isotopes from N = 28 to N = 46: probes for core polarization effects

Measurements of the ground-state nuclear spins, magnetic and quadrupole moments of the copper isotopes from 61Cu up to 75Cu are reported. The experiments were performed at the ISOLDE facility, using the technique of collinear laser spectroscopy. The trend in the magnetic moments between the N=28 and N=50 shell closures is reasonably reproduced by large-scale shell-model calculations starting from a 56Ni core. The quadrupole moments reveal a strong polarization of the underlying Ni core when the neutron shell is opened, which is however strongly reduced at N=40 due to the parity change between the $pf$ and $g$ orbits. No enhanced core polarization is seen beyond N=40. Deviations between measured and calculated moments are attributed to the softness of the 56Ni core and weakening of the Z=28 and N=28 shell gaps.Comment: 13 pagers, 19 figures, accepted by Physical Review

A Versatile Computational Pipeline for Bacterial Genome Annotation Improvement and Comparative Analysis, with \u3cem\u3eBrucella\u3c/em\u3e as a Use Case

We present a bacterial genome computational analysis pipeline, called GenVar. The pipeline, based on the program GeneWise, is designed to analyze an annotated genome and automatically identify missed gene calls and sequence variants such as genes with disrupted reading frames (split genes) and those with insertions and deletions (indels). For a given genome to be analyzed, GenVar relies on a database containing closely related genomes (such as other species or strains) as well as a few additional reference genomes. GenVar also helps identify gene disruptions probably caused by sequencing errors. We exemplify GenVar’s capabilities by presenting results from the analysis of four Brucella genomes. Brucella is an important human pathogen and zoonotic agent. The analysis revealed hundreds of missed gene calls, new split genes and indels, several of which are species specific and hence provide valuable clues to the understanding of the genome basis of Brucella pathogenicity and host specificity

New Constraints on Dispersive Form Factor Parameterizations from the Timelike Region

We generalize a recent model-independent form factor parameterization derived from rigorous dispersion relations to include constraints from data in the timelike region. These constraints dictate the convergence properties of the parameterization and appear as sum rules on the parameters. We further develop a new parameterization that takes into account finiteness and asymptotic conditions on the form factor, and use it to fit to the elastic \pi electromagnetic form factor. We find that the existing world sample of timelike data gives only loose bounds on the form factor in the spacelike region, but explain how the acquisition of additional timelike data or fits to other form factors are expected to give much better results. The same parameterization is seen to fit spacelike data extremely well.Comment: 24 pages, latex (revtex), 3 eps figure

Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus

The urea cycle disorders (UCDs) are important models for developing gene replacement therapy for liver diseases. Long-term correction of the most common UCD, ornithine transcarbamylase (OTC) deficiency, has yet to be achieved in clinical or preclinical settings. The single human clinical trial using early-generation adenovirus (Ad) failed to show any biochemical correction. In adult OTC-deficient mice, an E1/E2-deleted Ad vector expressing the mouse OTC gene, but not the human, was only transiently therapeutic. By using post-transcriptional overexpression in the context of the less immunogenic helper-dependent adenoviral vector, we achieved metabolic correction of adult OTC-deficient mice for \u3e6 months. Demonstrating this result were normalized orotic aciduria, normal hepatic enzyme activity, and elevated OTC RNA and protein levels in the absence of chronic hepatotoxicity. Overexpressing the human protein may have overcome two potential mechanisms accounting for poor cross-species complementation: a kinetic block at the level of mitochondrial import or a dominant negative effect by the mutant polypeptide. These data represent an important approach for treating human inborn errors of hepatocyte metabolism like the UCDs that require high-level transduction and gene expression for clinical correction

Isoscalar resonances with J^{PC}=1^{--} in e^+e^-annihilation

The analysis of the vector isoscalar excitations in the energy range between 1 and 2 GeV of the $e^+e^-$ annihilation is presented for the final states $\pi^+\pi^-\pi^0$, $\omega\pi^+\pi^-$, $K^+K^-$, $K^0_SK^\pm\pi^\mp$ and $K^{\ast0}K^-\pi^++ c.c$. The effects of both the resonance mixing and the successive opening of multiparticle channels, with the energy dependent partial widths, are taken into account. The work extends our previous analysis hep-ph/9609216 of the vector isovector excitations and is aimed to compare the existing data with the predictions of the $q\bar q$ model. It is shown that this hypothesis does not contradict the data.Comment: 16 pages, revtex, 6 ps figures. Clarifying remarks, a table, and references are added. Accepted in Phys. Rev.