258 research outputs found
An approximation principle for congruence subgroups
The motivating question of this paper is roughly the following: given a group scheme over , prime, with semisimple generic fiber , how far are open subgroups of from subgroups of the form , where is a subgroup scheme of and is the principal congruence subgroup ? More precisely, we will show that for simply connected there exist constants and , depending only on , such that any open subgroup of of level admits an open subgroup of index which is contained in for some proper connected algebraic subgroup of defined over . Moreover, if is defined over , then and can be taken independently of . We also give a correspondence between natural classes of -Lie subalgebras of and of closed subgroups of that can be regarded as a variant over of Nori's results on the structure of finite subgroups of for large . As an application we give a bound for the volume of the intersection of a conjugacy class in the group , for defined over , with an arbitrary open subgroup. In a future paper, this result will be applied to the limit multiplicity problem for arbitrary congruence subgroups of the arithmetic lattice
Why is there no queer international theory?
Over the last decade, Queer Studies have become Global Queer Studies, generating significant insights into key international political processes. Yet, the transformation from Queer to Global Queer has left the discipline of International Relations largely unaffected, which begs the question: if Queer Studies has gone global, why has the discipline of International Relations not gone somewhat queer? Or, to put it in Martin Wightâs provocative terms, why is there no Queer International Theory? This article claims that the presumed non-existence of Queer International Theory is an effect of how the discipline of International Relations combines homologization, figuration, and gentrification to code various types of theory as failures in order to manage the conduct of international theorizing in all its forms. This means there are generalizable lessons to be drawn from how the discipline categorizes Queer International Theory out of existence to bring a specific understanding of International Relations into existence
Agitation in cognitive disorders: Progress in the International Psychogeriatric Association consensus clinical and research definition
Background: The International Psychogeriatric Association (IPA) published a provisional consensus definition of agitation in cognitive disorders in 2015. As proposed by the original work group, we summarize the use and validation of criteria in order to remove "provisional" from the definition. Methods: This report summarizes information from the academic literature, research resources, clinical guidelines, expert surveys, and patient and family advocates on the experience of use of the IPA definition. The information was reviewed by a working group of topic experts to create a finalized definition. Results: We present a final definition which closely resembles the provisional definition with modifications to address special circumstances. We also summarize the development of tools for diagnosis and assessment of agitation and propose strategies for dissemination and integration into precision diagnosis and agitation interventions. Conclusion: The IPA definition of agitation captures a common and important entity that is recognized by many stakeholders. Dissemination of the definition will permit broader detection and can advance research and best practices for care of patients with agitation.publishedVersio
Reduction and prevention of agitation in persons with neurocognitive disorders: an international psychogeriatric association consensus algorithm
Objectives: To develop an agitation reduction and prevention algorithm is intended to guide implementation of the definition of agitation developed by the International Psychogeriatric Association (IPA). Design: Review of literature on treatment guidelines and recommended algorithms; algorithm development through reiterative integration of research information and expert opinion. Setting: IPA Agitation Workgroup. Participants: IPA panel of international experts on agitation. Intervention: Integration of available information into a comprehensive algorithm. Measurements: None. Results: The IPA Agitation Work Group recommends the Investigate, Plan, and Act (IPA) approach to agitation reduction and prevention. A thorough investigation of the behavior is followed by planning and acting with an emphasis on shared decision-making; the success of the plan is evaluated and adjusted as needed. The process is repeated until agitation is reduced to an acceptable level and prevention of recurrence is optimized. Psychosocial interventions are part of every plan and are continued throughout the process. Pharmacologic interventions are organized into panels of choices for nocturnal/circadian agitation; mild-moderate agitation or agitation with prominent mood features; moderate-severe agitation; and severe agitation with threatened harm to the patient or others. Therapeutic alternatives are presented for each panel. The occurrence of agitation in a variety of venues-home, nursing home, emergency department, hospice-and adjustments to the therapeutic approach are presented. Conclusions: The IPA definition of agitation is operationalized into an agitation management algorithm that emphasizes the integration of psychosocial and pharmacologic interventions, reiterative assessment of response to treatment, adjustment of therapeutic approaches to reflect the clinical situation, and shared decision-making.publishedVersio
On unitarizability in the case of classical p-adic groups
In the introduction of this paper we discuss a possible approach to the
unitarizability problem for classical p-adic groups. In this paper we give some
very limited support that such approach is not without chance. In a forthcoming
paper we shall give additional evidence in generalized cuspidal rank (up to)
three.Comment: This paper is a merged and revised version of ealier preprints
arXiv:1701.07658 and arXiv:1701.07662. The paper is going to appear in the
Proceedings of the Simons Symposium on Geometric Aspects of the Trace Formul
Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of NOD mice to an inducer of accelerated diabetes
One's present repertoire of antibodies encodes the history of one's past
immunological experience. Can the present autoantibody repertoire be consulted
to predict resistance or susceptibility to the future development of an
autoimmune disease? Here we developed an antigen microarray chip and used
bioinformatic analysis to study a model of type 1 diabetes developing in
non-obese diabetic (NOD) male mice in which the disease was accelerated and
synchronized by exposing the mice to cyclophosphamide at 4 weeks of age. We
obtained sera from 19 individual mice, treated the mice to induce
cyclophosphamide-accelerated diabetes (CAD), and found, as expected, that 9
mice became severely diabetic while 10 mice permanently resisted diabetes. We
again obtained serum from each mouse afterCAD induction. We then analyzed the
patterns of antibodies in the individualmice to 266 different antigens spotted
on the antigen chip. We identified a select panel of 27 different antigens (10%
of the array) that revealed a pattern of IgG antibody reactivity in the pre-CAD
serathat discriminated between the mice resistant or susceptible to CAD with
100% sensitivity and 82% specificity (p=0.017). Surprisingly, the set of IgG
antibodies that was informative before CAD induction did not separate the
resistant and susceptible groups after the onset of CAD; new antigens became
criticalfor post-CAD repertoire discrimination. Thus, at least for a model
disease, present antibody repertoires can predict future disease; predictive
and diagnostic repertoires can differ; and decisive information about immune
system behavior can be mined by bioinformatic technology. Repertoires matter.Comment: See Advanced Publication on the PNAS website for final versio
Spontaneous regression of congenital epulis: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p>Congenital epulis is a rare lesion found on the alveolar process of a newborn child, diagnosed soon after birth. The lesion has a site predilection for the anterior maxillary alveolar process and a 9:1 sex predilection for females. Once diagnosed the traditional management of the lesion has been surgical excision under general anesthesia.</p> <p>Case presentation</p> <p>The purpose of this case report is to describe spontaneous regression of congenital epulis in a three week old healthy African American female child. She presented with a 1.5 cm bilobed sessile nodular lesion in the region of the right maxillary cuspid. The clinical impression was congenital epulis. Since the lesion was not interfering with feeding and respiration, a conservative approach was taken. The child was followed-up for 18 months, during which the lesion progressively regressed.</p> <p>Conclusions</p> <p>Conservative management prevented unnecessary surgery and anesthesia exposure in a neonate.</p
The detection rate of early UV emission from supernovae: A dedicated GALEX/PTF survey and calibrated theoretical estimates
The radius and surface composition of an exploding massive star,as well as
the explosion energy per unit mass, can be measured using early UV observations
of core collapse supernovae (SNe). We present the first results from a
simultaneous GALEX/PTF search for early UV emission from SNe. Six Type II SNe
and one Type II superluminous SN (SLSN-II) are clearly detected in the GALEX
NUV data. We compare our detection rate with theoretical estimates based on
early, shock-cooling UV light curves calculated from models that fit existing
Swift and GALEX observations well, combined with volumetric SN rates. We find
that our observations are in good agreement with calculated rates assuming that
red supergiants (RSGs) explode with fiducial radii of 500 solar, explosion
energies of 10^51 erg, and ejecta masses of 10 solar masses. Exploding blue
supergiants and Wolf-Rayet stars are poorly constrained. We describe how such
observations can be used to derive the progenitor radius, surface composition
and explosion energy per unit mass of such SN events, and we demonstrate why UV
observations are critical for such measurements. We use the fiducial RSG
parameters to estimate the detection rate of SNe during the shock-cooling phase
(<1d after explosion) for several ground-based surveys (PTF, ZTF, and LSST). We
show that the proposed wide-field UV explorer ULTRASAT mission, is expected to
find >100 SNe per year (~0.5 SN per deg^2), independent of host galaxy
extinction, down to an NUV detection limit of 21.5 mag AB. Our pilot GALEX/PTF
project thus convincingly demonstrates that a dedicated, systematic SN survey
at the NUV band is a compelling method to study how massive stars end their
life.Comment: See additional information including animations on
http://www.weizmann.ac.il/astrophysics/ultrasa
- âŠ