Molar ratios of therapeutic water-soluble phenothiazine⋅water-insoluble phospholipid adducts reveal a Fibonacci correlation and a putative link for structure–activity relationships

The fact that non-antibiotics can sensitise microorganisms for antibiotic treatment suggests that these molecules have valuable potential to treat multiple drug resistance.</p

Situationsbaseret projektvejledning

Projektvejledning vil altid være afhængig af den konkrete situation og skal derfor tilpasses de institutionelle rammer, de faglige mål, de studerende og projektprocessen. I denne artikel udfoldes forståelsen af vejledning ud fra begrebet situationsbaseret vejledning. Det handler om at kunne aflæse de studerendes samarbejdsmønstre og behov i de forskellige faser af projektarbejdet og vælge de bedst mulige undervisningsstrategier til at skabe en progression hen imod de opstillede læringsmål. Projektvejlederen skal kunne være i stand til at veksle imellemforskellige strategier, roller og funktioner afhængig af behovet. En del af udfordringen kan imødegås ved planlægningen og refleksion over samarbejdet med gruppen, men en del ligger også i at være opmærksom og spørge ind til de studerendes behov i selve vejledningssituationen. Heri ligger kunsten at kunne praktisere situationsbaseret projektvejledning

A multiple length scale description of the mechanism of elastomer stretching

Conventionally, the stretching of rubber is modeled exclusively by rotations of segments of the embedded polymer chains; i.e. changes in entropy.</p

Phenothiazines as a solution for multidrug resistant tuberculosis: From the origin to present

Historically, multiplicity of actions in synthetic compounds is a rule rather than exception. The science of non-antibiotics evolved in this background. From the antimalarial and antitrypanosomial dye methylene blue, chemically similar compounds, the phenothiazines, were developed. The phenothiazines were first recognised for their antipsychotic properties, but soon after their antimicrobial functions came to be known and then such compounds were designated as non-antibiotics. The emergence of highly drug-resistant bacteria had initiated an urgent need to search for novel affordable compounds. Several phenothiazines awakened the interest among scientists to determine their antimycobacterial activity. Chlorpromazine, trifluoperazine, methdilazine and thioridazine were found to have distinct antitubercular action. Thioridazine took the lead as researchers repeatedly claimed its potentiality. Although thioridazine is known for its central nervous system and cardiotoxic side-effects, extensive and repeated in vitro and in vivo studies by several research groups revealed that a very small dose of thioridazine is required to kill tubercle bacilli inside macrophages in the lungs, where the bacteria try to remain and multiply silently. Such a small dose is devoid of its adverse side-effects. Recent studies have shown that the (&ndash;) thioridazine is a more active antimicrobial agent and devoid of the toxic side effects normally encountered. This review describes the possibilities of bringing down thioridazine and its (&ndash;) form to be combined with other antitubercular drugs to treat infections by drug-resistant strains of Mycobacterium tuberculosis and try to eradicate this deadly disease. [Int Microbiol 2015; 18(1):1-12]Keywords: Mycobacterium tuberculosis &middot; phenotiazines &middot; thioridazine &middot; tuberculosi

Sustainability Matters

The purpose of this study was to identify patterns of change in students’ awareness of, interest in and engagement with sustainability issues during the process of acclimatisation to their PBL engineering studies, and to look for differences between engineering disciplines with respect to these aspects. This study used a longitudinal qualitative approach with a theory-led thematic analysis. There were 16 participants in total, interviewed at 3 intervals during a period of 18 months at a faculty of engineering in Denmark. The authors found a pattern of increase in sustainability awareness, interest, and engagement throughout the three semesters of the study. Some differences between engineering disciplines were visible, especially between sustainability-oriented engineering and the others. Most students who increased their sustainability awareness and interest were also likely to engage further with the topic. That engagement built up from individual engagement, to professional engagement and for some, into institutional and public sphere engagement. The findings are timely given the pressure faced by engineering education to incorporate sustainability issues. It provides avenues for educating engineering graduates who will display interest, awareness, and engagement with sustainability issues. It suggests institutional engagement as a potential avenue to explore for engineering educators

Phenothiazines as a solution for multidrug resistant tuberculosis:From the origin to present

Historically, multiplicity of actions in synthetic compounds is a rule rather than exception. The science of non-antibiotics evolved in this background. From the antimalarial and antitrypanosomial dye methylene blue, chemically similar compounds, the phenothiazines, were developed. The phenothiazines were first recognised for their antipsychotic properties, but soon after their antimicrobial functions came to be known and then such compounds were designated as non-antibiotics. The emergence of highly drug-resistant bacteria had initiated an urgent need to search for novel affordable compounds. Several phenothiazines awakened the interest among scientists to determine their antimycobacterial activity. Chlorpromazine, trifluoperazine, methdilazine and thioridazine were found to have distinct antitubercular action. Thioridazine took the lead as researchers repeatedly claimed its potentiality. Although thioridazine is known for its central nervous system and cardiotoxic side-effects, extensive and repeated in vitro and in vivo studies by several research groups revealed that a very small dose of thioridazine is required to kill tubercle bacilli inside macrophages in the lungs, where the bacteria try to remain and multiply silently. Such a small dose is devoid of its adverse side-effects. Recent studies have shown that the (&ndash;) thioridazine is a more active antimicrobial agent and devoid of the toxic side effects normally encountered. This review describes the possibilities of bringing down thioridazine and its (&ndash;) form to be combined with other antitubercular drugs to treat infections by drug-resistant strains of Mycobacterium tuberculosis and try to eradicate this deadly disease. [Int Microbiol 2015; 18(1):1-12]Keywords: Mycobacterium tuberculosis &middot; phenotiazines &middot; thioridazine &middot; tuberculosi