Matter power spectrum for the generalized Chaplygin gas model: The relativistic case

The generalized Chaplygin gas (GCG) model is the prototype of a unified model of dark energy (DE) and dark matter (DM). It is characterized by equation-of-state (EoS) parameters $A$ and $\alpha$. We use a statistical analysis of the 2dFGRS data to constrain these parameters. In particular, we find that very small (close to zero) and very large values ($\alpha\gg 1$) of the equation-of-state parameter $\alpha$ are preferred. To test the validity of this type of unification of the dark sector we admit the existence of a separate DM component in addition to the Chaplygin gas and calculate the probability distribution for the fractional contributions of both components to the total energy density. This analysis favors a model for which the Universe is nearly entirely made up of the separate DM component with an almost negligible Chaplygin gas part. This confirms the results of a previous Newtonian analysis.Comment: Latex file, 8 pages, 15 figures in eps forma

Newtonian View of General Relativistic Stars

Although general relativistic cosmological solutions, even in the presence of pressure, can be mimicked by using neo-Newtonian hydrodynamics, it is not clear whether there exists the same Newtonian correspondence for spherical static configurations. General relativity solutions for stars are known as the Tolman-Oppenheimer-Volkoff (TOV) equations. On the other hand, the Newtonian description does not take into account the total pressure effects and therefore can not be used in strong field regimes. We discuss how to incorporate pressure in the stellar equilibrium equations within the neo-Newtonian framework. We compare the Newtonian, neo-Newtonian and the full relativistic theory by solving the equilibrium equations for both three approaches and calculating the mass-radius diagrams for some simple neutron stars equation of state.Comment: 6 pages, 3 figures. v2 matches accepted version (EPJC

A note on acoustic black holes in neo-Newtonian theory

Newtonian fluid dynamics allows the construction of acoustic metrics from which black hole configurations can be studied. However, relativistic pressure effects are neglected within Newtonian theory. We study acoustic black holes in the framework of neo-Newtonian hydrodynamics, which is designed to take into account relativistic inertial effects of the pressure $p$. Within this new hydrodynamical context we show how $p$ can influence the formation of the acoustic horizons.Comment: Latex file, 10 pages. Some discussions extended. Accepted for publication in MPL

Viscous Cosmology

We discuss the possibility to implement a viscous cosmological model, attributing to the dark matter component a behaviour described by bulk viscosity. Since bulk viscosity implies negative pressure, this rises the possibility to unify the dark sector. At the same time, the presence of dissipative effects may alleviate the so called small scale problems in the $\Lambda$CDM model. While the unified viscous description for the dark sector does not lead to consistent results, the non-linear behaviour indeed improves the situation with respect to the standard cosmological model.Comment: Latex file, 7 pages, 6 figures. To appear in the proceedings of the XIIth International Conference on Gravitation, Astrophysics and Cosmology, June 28-July 5, 2015, PFUR, Moscow, Russi

Myocardial Dysfunction in an Animal Model of Cancer Cachexia

Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease. In rodents, tumor-induced fatigue is associated with a progressive loss of skeletal muscle mass and increased expression of biomarkers of muscle protein degradation. The purpose of the present study was to determine if muscle wasting and expression of biomarkers of muscle protein degradation occur in the hearts of tumor-bearing mice, and if these effects of tumor growth are associated with changes in cardiac function. Main methods The colon26 adenocarcinoma cell line was implanted into female CD2F1 mice and skeletal muscle wasting, in vivo heart function, in vitro cardiomyocyte function, and biomarkers of muscle protein degradation were determined. Key findings Expression of biomarkers of protein degradation were increased in both the gastrocnemius and heart muscle of tumor-bearing mice and caused systolic dysfunction in vivo. Cardiomyocyte function was significantly depressed during both cellular contraction and relaxation. Significance These results suggest that heart muscle is directly affected by tumor growth, with myocardial function more severely compromised at the cellular level than what is observed using echocardiography

Losartan Treatment Attenuates Tumor-induced Myocardial Dysfunction

Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which could contribute to fatigue in cancer patients. In clinical studies, inhibitors of angiotensin converting enzyme (ACE) can prevent the development of chemotherapy-induced cardiovascular dysfunction, suggesting a mechanistic role for the renin–angiotensin–aldosterone system (RAAS). In the present study, we investigated whether an angiotensin (AT) 1-receptor antagonist could prevent the development of tumor-associated myocardial dysfunction. Methods and results: Colon26 adenocarcinoma (c26) cells were implanted into female CD2F1 mice at 8 weeks of age. Simultaneously, mice were administered Losartan (10 mg/kg) daily via their drinking water. In vivo echocardiography, blood pressure, in vitro cardiomyocyte function, cell proliferation assays, and measures of systemic inflammation and myocardial protein degradation were performed 19 days following tumor cell injection. Losartan treatment prevented tumor-induced loss of muscle mass and in vitro c26 cell proliferation, decreased tumor weight, and attenuated myocardial expression of interleukin-6. Furthermore, Losartan treatment mitigated tumor-associated alterations in calcium signaling in cardiomyocytes, which was associated with improved myocyte contraction velocity, systolic function, and blood pressures in the hearts of tumor-bearing mice. Conclusions: These data suggest that Losartan may mitigate tumor-induced myocardial dysfunction and inflammation

Femto-photography: capturing and visualizing the propagation of light

We present femto-photography, a novel imaging technique to capture and visualize the propagation of light. With an effective exposure time of 1.85 picoseconds (ps) per frame, we reconstruct movies of ultrafast events at an equivalent resolution of about one half trillion frames per second. Because cameras with this shutter speed do not exist, we re-purpose modern imaging hardware to record an ensemble average of repeatable events that are synchronized to a streak sensor, in which the time of arrival of light from the scene is coded in one of the sensor's spatial dimensions. We introduce reconstruction methods that allow us to visualize the propagation of femtosecond light pulses through macroscopic scenes; at such fast resolution, we must consider the notion of time-unwarping between the camera's and the world's space-time coordinate systems to take into account effects associated with the finite speed of light. We apply our femto-photography technique to visualizations of very different scenes, which allow us to observe the rich dynamics of time-resolved light transport effects, including scattering, specular reflections, diffuse interreflections, diffraction, caustics, and subsurface scattering. Our work has potential applications in artistic, educational, and scientific visualizations; industrial imaging to analyze material properties; and medical imaging to reconstruct subsurface elements. In addition, our time-resolved technique may motivate new forms of computational photography.MIT Media Lab ConsortiumLincoln LaboratoryMassachusetts Institute of Technology. Institute for Soldier NanotechnologiesAlfred P. Sloan Foundation (Research Fellowship)United States. Defense Advanced Research Projects Agency (Young Faculty Award