De Ruimtescanner in Ruimte voor Landbouw; data- en modelaanpassingen

Dit rapport is bedoeld als technisch achtergronddocument bij de studie 'Ruimte voor Landbouw'. Die studie is in samenwerking uitgevoerd door het Ruimtelijke Planbureau (RPB), het Milieu- en Natuurplanbureau (MNP), het LEI en de VU, en betreft de toepassing van de Ruimtescanner om de toekomstige ruimtelijke ontwikkeling van de landbouw te verkennen

Relationship between polarities of antibiotic and polymer matrix on nanoparticle formulations based on aliphatic polyesters

In the field of nanomedicine, nanoparticles are developed to target antibiotics to sites of bacterial infection thus enabling adequate drug exposure and decrease development of resistant bacteria. In the present study, we investigated the encapsulation of two antibiotics with different polarity into different PEGylated polymeric nanoparticles based on aliphatic polyesters, to obtain a better understanding of critical factors determining encapsulation and release. The nanoparticles were prepared from diblock copolymers comprising of a poly(ethylene glycol) block attached to an aliphatic polyester block of varying polarity: poly(lactic-co-glycolic acid) (mPEG-PLGA), poly(lactic-co-hydroxymethyl glycolic acid) (mPEG-PLHMGA) and poly(lactic-co-benzyloxymethyl glycolic acid) (mPEG-PLBMGA). Hydrophobic bedaquiline and hydrophilic vancomycin were encapsulated via single and double-emulsion solvent evaporation techniques, respectively. Encapsulation, degradation and release studies at physiological simulating conditions were performed. Drug polarity and preparation techniques influenced encapsulation efficiency into polymer nanoparticles, giving almost complete encapsulation of bedaquiline and approx. 30% for vancomycin independent of the polymer type. The nonpolar bedaquiline showed a predominantly diffusion-controlled release independent of polymer composition. However, polar vancomycin was released by a combination of diffusion and polymer degradation, which was significantly affected by polymer composition, the most hydrophilic polymer displaying the fastest release

Development of anisotropic structure in the Earth's lower mantle by solid-state convection

Seismological observations reveal highly anisotropic patches at the bottom of the Earth's lower mantle, whereas the bulk of the mantle has been observed to be largely isotropic(1-4). These patches have been interpreted to correspond to areas where subduction has taken place in the past or to areas where mantle plumes are upwelling, but the underlying cause for the anisotropy is unknown-both shape-preferred orientation of elastically heterogenous materials(5) and lattice-preferred orientation of a homogeneous material(6-8) have been proposed. Both of these mechanisms imply that large-strain deformation occurs within the anisotropic regions, but the geodynamic implications of the mechanisms differ. Shape-preferred orientation would imply the presence of large elastic (and hence chemical) heterogeneity whereas lattice-preferred orientation requires deformation at high stresses. Here we show, on the basis of numerical modelling incorporating mineral physics of elasticity and development of lattice-preferred orientation, that slab deformation in the deep lower mantle can account for the presence of strong anisotropy in the circum-Pacific region. In this model-where development of the mineral fabric (the alignment of mineral grains) is caused solely by solid-state deformation of chemically homogeneous mantle material-anisotropy is caused by large-strain deformation at high stresses, due to the collision of subducted slabs with the core-mantle boundary.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62804/1/416310a.pd

AN EROSION MODEL AS A TOOL FOR FARMERS INVOLVEMENT FOR DEFINING LAND USE STRATEGIES IN FIJI AND SAMOA

Abstract South Pacific islands are under increasing pressure, and the threats are primarily from human interactions. The arrival of western values in the South Pacific resulted in forest depletion and intensive agricultural production systems, which have led to increasing damage to the environment, while bringing relatively few benefits to the resource owners. The pressure to which natural resources have been subjected by these development efforts, and the substantial and sometimes disastrous degradation and depletion which have occurred, has begun to focus the attention of communities on the need to implement sustainable management of those remaining resources. At present, crop production systems practiced in South Pacific Island States range from traditional to high input production systems. The majority of the farmers in Fiji and Samoa fall within these two extremes in what will be termed moderate input production systems. The physically based model LISEM is used to quantify the losses of soil and water in two small agricultural catchments in Samoa and Fiji. To be able to communicate directly with the farmers about the effects of proposed alternative land use on the spot calculation-results will be presented during village meetings. Calibration of the model showed that results for calculated discharge matches the measured values. In both catchments, demonstration areas of alternative land use strategies are implemented. Modeling tools will be used in the negotiation process with local stakeholders to come to feasible, reliable and acceptable alternative land management and land use strategies to increase people's welfare and reduce soil degradation and environmental pollution. Additional Keywords: soil erosion, conservation, modeling, participation Introduction The increasing population pressures and emerging trends of socio-economic marginalization or rural populations are putting a heavy strain on the delicate ecosystems of the Pacific Island Countries. In response to the rapidly increasing demands for food, Pacific farmers abandon traditional farming systems to adopt high input commercial production methods for short term gains, which are often unsustainable, in particular on sloping lands. The resulting erosion causes rapid depletion of soil fertility as well as pollution of ground-and open-water systems. The CROPPRO project aims to provide assistance to Pacific Island countries with the development of integrated farming approaches for sustainable crop production in environmentally constrained systems. The project specifically addresses the relation between agricultural activities and the surrounding environment, and focuses on the development of tailor-made farming approaches for major crop/soil units aiming at maximising agricultural production and minimising environmental deterioration. Special attention will be paid to knowledge transfer and participatory, culture-sensitive training for stakeholders and end-users. The project is funded by the EU, INO-DC and the Ministry of Agriculture, Nature and Fisheries of The Netherland

Deep storage of oceanic crust in a vigorously convecting mantle

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94626/1/jgrb15203.pd

Short-Term Variability of the QT Interval Can be Used for the Prediction of Imminent Ventricular Arrhythmias in Patients With Primary Prophylactic Implantable Cardioverter Defibrillators

Background Short-term variability of the QT interval (STVQT) has been proposed as a novel electrophysiological marker for the prediction of imminent ventricular arrhythmias in animal models. Our aim is to study whether STVQT can predict imminent ventricular arrhythmias in patients. Methods and Results In 2331 patients with primary prophylactic implantable cardioverter defibrillators, 24-hour ECG Holter recordings were obtained as part of the EU-CERT-ICD (European Comparative Effectiveness Research to Assess the Use of Primary Prophylactic Implantable Cardioverter Defibrillators) study. ECG Holter recordings showing ventricular arrhythmias of >4 consecutive complexes were selected for the arrhythmic groups (n=170), whereas a control group was randomly selected from the remaining Holter recordings (n=37). STVQT was determined from 31 beats with fiducial segment averaging and calculated as [Formula: see text], where Dn represents the QT interval. STVQT was determined before the ventricular arrhythmia or 8:00 am in the control group and between 1:30 and 4:30 am as baseline. STVQT at baseline was 0.84±0.47 ms and increased to 1.18±0.74 ms (P<0.05) before the ventricular arrhythmia, whereas the STVQT in the control group remained unchanged. The arrhythmic patients were divided into three groups based on the severity of the arrhythmia: (1) nonsustained ventricular arrhythmia (n=32), (2) nonsustained ventricular tachycardia (n=134), (3) sustained ventricular tachycardia (n=4). STVQT increased before nonsustained ve

Stochastic Inversion of P-to-S Converted Waves for Mantle Composition and Thermal Structure: Methodology and Application

We present a new methodology for inverting P‐to‐S receiver function (RF) waveforms directly for mantle temperature and composition. This is achieved by interfacing the geophysical inversion with self‐consistent mineral phase equilibria calculations from which rock mineralogy and its elastic properties are predicted as a function of pressure, temperature, and bulk composition. This approach anchors temperatures, composition, seismic properties, and discontinuities that are in mineral physics data, while permitting the simultaneous use of geophysical inverse methods to optimize models of seismic properties to match RF waveforms. Resultant estimates of transition zone (TZ) topography and volumetric seismic velocities are independent of tomographic models usually required for correcting for upper mantle structure. We considered two end‐member compositional models: the equilibrated equilibrium assemblage (EA) and the disequilibrated mechanical mixture (MM) models. Thermal variations were found to influence arrival times of computed RF waveforms, whereas compositional variations affected amplitudes of waves converted at the TZ discontinuities. The robustness of the inversion strategy was tested by performing a set of synthetic inversions in which crustal structure was assumed both fixed and variable. These tests indicate that unaccounted‐for crustal structure strongly affects the retrieval of mantle properties, calling for a two‐step strategy presented herein to simultaneously recover both crustal and mantle parameters. As a proof of concept, the methodology is applied to data from two stations located in the Siberian and East European continental platforms.This work was supported by a grant from the Swiss National Science Foundation (SNF project 200021_159907). B. T. was funded by a Délégation CNRS and Congé pour Recherches et Conversion Thématique from the Université de Lyon to visit the Research School of Earth Sciences (RSES), The Australian National University (ANU). B. T. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 79382