Mass measurements in the vicinity of the doubly-magic waiting point 56Ni

Masses of 56,57Fe, 53Co^m, 53,56Co, 55,56,57Ni, 57,58Cu, and 59,60Zn have been determined with the JYFLTRAP Penning trap mass spectrometer at IGISOL with a precision of dm/m \le 3 x 10^{-8}. The QEC values for 53Co, 55Ni, 56Ni, 57Cu, 58Cu, and 59Zn have been measured directly with a typical precision of better than 0.7 keV and Coulomb displacement energies have been determined. The Q values for proton captures on 55Co, 56Ni, 58Cu, and 59Cu have been measured directly. The precision of the proton-capture Q value for 56Ni(p,gamma)57Cu, Q(p,gamma) = 689.69(51) keV, crucial for astrophysical rp-process calculations, has been improved by a factor of 37. The excitation energy of the proton emitting spin-gap isomer 53Co^m has been measured precisely, Ex = 3174.3(10) keV, and a Coulomb energy difference of 133.9(10) keV for the 19/2- state has been obtained. Except for 53Co, the mass values have been adjusted within a network of 17 frequency ratio measurements between 13 nuclides which allowed also a determination of the reference masses 55Co, 58Ni, and 59Cu.Comment: 14 pages, 13 figures, submitted to Phys. Rev.

Non-Gaussianities in two-field inflation

We study the bispectrum of the curvature perturbation on uniform energy density hypersurfaces in models of inflation with two scalar fields evolving simultaneously. In the case of a separable potential, it is possible to compute the curvature perturbation up to second order in the perturbations, generated on large scales due to the presence of non-adiabatic perturbations, by employing the $\delta N$-formalism, in the slow-roll approximation. In this case, we provide an analytic formula for the nonlinear parameter $f_{NL}$. We apply this formula to double inflation with two massive fields, showing that it does not generate significant non-Gaussianity; the nonlinear parameter at the end of inflation is slow-roll suppressed. Finally, we develop a numerical method for generic two-field models of inflation, which allows us to go beyond the slow-roll approximation and confirms our analytic results for double inflation.Comment: 29 pages, 6 figures. v2, comparison with previous estimates. v3, JCAP version; Revisions based on Referee's comment, corrected typos, added few eqs and refs, conclusions unchange

The transformative potential of reflective diaries for elite English cricketers

The sport of cricket has a history of its players suffering from mental health issues. The psychological study of cricket and, in particular, the attendant demands of participating at an elite level has not previously received rigorous academic attention. This study explored ten elite male cricketers’ experiences of keeping a daily reflective diary for one month during the competitive season. The aim was to assess how valuable qualitative diaries are in this field. Participants were interviewed regarding their appraisal of the methodology as a self‐help tool that could assist coping with performance pressures and wider life challenges. Three outcomes were revealed: first, that diary keeping was an effective opportunity to reflect upon the past and enhance one’s self (both as an individual and a performer); second, that diary keeping acted as a form of release that allowed participants to progress; and third, that diary keeping allowed participants to discover personal patterns of success that increased the likeliness of optimum performance

Non-Gaussianity in braneworld and tachyon inflation

We calculate the bispectrum of single-field braneworld inflation, triggered by either an ordinary scalar field or a cosmological tachyon, by means of a gradient expansion of large-scale non-linear perturbations coupled to stochastic dynamics. The resulting effect is identical to that for single-field 4D standard inflation, the non-linearity parameter being proportional to the scalar spectral index in the limit of collapsing momentum. If the slow-roll approximation is assumed, braneworld and tachyon non-Gaussianities are subdominant with respect to the post-inflationary contribution. However, bulk physics may considerably strengthen the non-linear signatures. These features do not change significantly when considered in a non-commutative framework.Comment: 17 pages; v2: added references and previously skipped details in the derivation of the result; v3: improved discussio

Large Nongaussianity from Nonlocal Inflation

We study the possibility of obtaining large nongaussian signatures in the Cosmic Microwave Background in a general class of single-field nonlocal hill-top inflation models. We estimate the nonlinearity parameter f_{NL} which characterizes nongaussianity in such models and show that large nongaussianity is possible. For the recently proposed p-adic inflation model we find that f_{NL} ~ 120 when the string coupling is order unity. We show that large nongaussianity is also possible in a toy model with an action similar to those which arise in string field theory.Comment: 27 pages, no figures. Added references and some clarifying remark

Incidence of community-acquired lower respiratory tract infections and pneumonia among older adults in the United Kingdom: a population-based study.

Community-acquired lower respiratory tract infections (LRTI) and pneumonia (CAP) are common causes of morbidity and mortality among those aged ≥65 years; a growing population in many countries. Detailed incidence estimates for these infections among older adults in the United Kingdom (UK) are lacking. We used electronic general practice records from the Clinical Practice Research Data link, linked to Hospital Episode Statistics inpatient data, to estimate incidence of community-acquired LRTI and CAP among UK older adults between April 1997-March 2011, by age, sex, region and deprivation quintile. Levels of antibiotic prescribing were also assessed. LRTI incidence increased with fluctuations over time, was higher in men than women aged ≥70 and increased with age from 92.21 episodes/1000 person-years (65-69 years) to 187.91/1000 (85-89 years). CAP incidence increased more markedly with age, from 2.81 to 21.81 episodes/1000 person-years respectively, and was higher among men. For both infection groups, increases over time were attenuated after age-standardisation, indicating that these rises were largely due to population aging. Rates among those in the most deprived quintile were around 70% higher than the least deprived and were generally higher in the North of England. GP antibiotic prescribing rates were high for LRTI but lower for CAP (mostly due to immediate hospitalisation). This is the first study to provide long-term detailed incidence estimates of community-acquired LRTI and CAP in UK older individuals, taking person-time at risk into account. The summary incidence commonly presented for the ≥65 age group considerably underestimates LRTI/CAP rates, particularly among older individuals within this group. Our methodology and findings are likely to be highly relevant to health planners and researchers in other countries with aging populations

Curvaton Dynamics in Brane-worlds

We study the curvaton dynamics in brane-world cosmologies. Assuming that the inflaton field survives without decay after the end of inflation, we apply the curvaton reheating mechanism to Randall-Sundrum and to its curvature corrections: Gauss-Bonnet, induced gravity and combined Gauss-Bonnet and induced gravity cosmological models. In the case of chaotic inflation and requiring suppression of possible short-wavelength generated gravitational waves, we constraint the parameters of a successful curvaton brane-world cosmological model. If density perturbations are also generated by the curvaton field then, the fundamental five-dimensional mass could be much lower than the Planck massComment: 47 pages, 1 figure, references added, to be published in JCA

Developing European conservation and mitigation tools for pollination services: approaches of the STEP (Status and Trends of European Pollinators) project

Pollinating insects form a key component of European biodiversity, and provide a vital ecosystem service to crops and wild plants. There is growing evidence of declines in both wild and domesticated pollinators, and parallel declines in plants relying upon them. The STEP project (Status and Trends of European Pollinators, 2010-2015, www.stepproject.net) is documenting critical elements in the nature and extent of these declines, examining key functional traits associated with pollination deficits, and developing a Red List for some European pollinator groups. Together these activities are laying the groundwork for future pollinator monitoring programmes. STEP is also assessing the relative importance of potential drivers of pollinator declines, including climate change, habitat loss and fragmentation, agrochemicals, pathogens, alien species, light pollution, and their interactions. We are measuring the ecological and economic impacts of declining pollinator services and floral resources, including effects on wild plant populations, crop production and human nutrition. STEP is reviewing existing and potential mitigation options, and providing novel tests of their effectiveness across Europe. Our work is building upon existing and newly developed datasets and models, complemented by spatially-replicated campaigns of field research to fill gaps in current knowledge. Findings are being integrated into a policy-relevant framework to create evidence-based decision support tools. STEP is establishing communication links to a wide range of stakeholders across Europe and beyond, including policy makers, beekeepers, farmers, academics and the general public. Taken together, the STEP research programme aims to improve our understanding of the nature, causes, consequences and potential mitigation of declines in pollination services at local, national, continental and global scales

One-loop corrections to a scalar field during inflation

The leading quantum correction to the power spectrum of a gravitationally-coupled light scalar field is calculated, assuming that it is generated during a phase of single-field, slow-roll inflation.Comment: 33 pages, uses feynmp.sty and ioplatex journal style. v2: matches version published in JCAP. v3: corrects sign error in Eq. (58). Corrects final coefficient of the logarithm in Eq. (105). Small corrections to discussion of divergences in 1-point function. Minor improvements to discussion of UV behaviour in Sec. 4.

In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration

We investigated the clinical, genetic, and pathological characteristics of a previously unknown severe juvenile brain disorder in several litters of Parson Russel Terriers. The disease started with epileptic seizures at 6–12 weeks of age and progressed rapidly to status epilepticus and death or euthanasia. Histopathological changes at autopsy were restricted to the brain. There was severe acute neuronal degeneration and necrosis diffusely affecting the grey matter throughout the brain with extensive intraneuronal mitochondrial crowding and accumulation of amyloid-β (Aβ). Combined homozygosity mapping and genome sequencing revealed an in-frame 6-bp deletion in the nuclear-encoded pitrilysin metallopeptidase 1 (PITRM1) encoding for a mitochondrial protease involved in mitochondrial targeting sequence processing and degradation. The 6-bp deletion results in the loss of two amino acid residues in the N-terminal part of PITRM1, potentially affecting protein folding and function. Assessment of the mitochondrial function in the affected brain tissue showed a significant deficiency in respiratory chain function. The functional consequences of the mutation were modeled in yeast and showed impaired growth in permissive conditions and an impaired respiration capacity. Loss-of-function variants in human PITRM1 result in a childhood-onset progressive amyloidotic neurological syndrome characterized by spinocerebellar ataxia with behavioral, psychiatric and cognitive abnormalities. Homozygous Pitrm1-knockout mice are embryonic lethal, while heterozygotes show a progressive, neurodegenerative phenotype characterized by impairment in motor coordination and Aβ deposits. Our study describes a novel early-onset PITRM1-related neurodegenerative canine brain disorder with mitochondrial dysfunction, Aβ accumulation, and lethal epilepsy. The findings highlight the essential role of PITRM1 in neuronal survival and strengthen the connection between mitochondrial dysfunction and neurodegeneration