Conception and preliminary evaluation of an optical fibre sensor for simultaneous measurement of pressure and temperature

peer-reviewedThis paper presents a novel concept of simultaneously measuring pressure and temperature using a silica optical fibre extrinsic Fabry-Perot interferometric (EFPI) pressure sensor incorporating a fibre Bragg grating (FBG), which is constructed entirely from fusedsilica. The novel device is used to simultaneously provide accurate pressure and temperature readings at the point of measurement. Furthermore, the FBG temperature measurement is used to eliminate the temperature cross-sensitivity of the EFPI pressure sensorPUBLISHEDpeer reviewe

The effect of nitrogen fertilization and no-till duration on soil nitrogen availability and greenhouse gas emissions

Non-Peer ReviewedWith a world population now greater than seven billion, it is imperative to conserve the arable land base, which is increasingly being leveraged by global demands for producing food, feed, fibre, and fuel. A key component of sustainable agriculture involves the restoration of unproductive lands that have been rendered unsuitable for agricultural production through anthropogenic soil degradation. The objective of this study was to determine the effect of varying fertilizer N rates on soil N availability and N2O and CO2 emissions of three soils collected at adjacent locations with contrasting management histories: native prairie or short-term (10 years) and long-term (32 years) no-till continuous multi-crop (wheat-pea-canola) cropping systems receiving five fertilizer N rates (0, 30, 60, 90, and 120 kg N/ha) for the previous nine years. Intact soil cores were collected from each site, maintained at field capacity, and incubated (22 oC) for six weeks. Weekly assessments of soil nutrient availability and N2O and CO2 emissions were completed to assess the impact of prolonged variable rates of fertilizer N and duration of no-till management of degraded agricultural soil relative to an adjacent native prairie soil. At the end of the six-week incubation, there was no significant difference (P > 0.15) in cumulative soil N supply rate between the unfertilized long-term no-till soil and native soil. Annual fertilizer N additions of 120 kg N/ha for the previous nine years were required to restore the N supplying power of the short-term no-till soil to that of the native soil, through the build-up of mineralizable N levels. As expected, repeated applications of fertilizer N increased the residual soil N levels in the cultivated soils compared to the native soil. The estimated cumulative CO2-C and N2O-N emissions at the end of the six-week incubation ranged from 231.8-474.7 g/m2 to 183.9-862.5 mg/m2, respectively. Repeated applications of ≥ 60 kg N/ha supported larger N2O-N fluxes in the long-term no-till soil compared to the unfertilized control. Highest CO2-C fluxes from the native prairie soil are consistent with its high organic matter content and contributions from root respiration. Surprisingly, the native prairie soil N2O-N emissions were equal to those from LTNT and STNT soils receiving repeated fertilizer N applications at typical agronomic rates and is probably characteristic of rapid denitrification rates during the dormant vegetative period after snow melt prior to the growing season within temperate native grassland environments. The use of modern no-till continuous multi-crop cropping systems, along with application of fertilizer N, enhances the soil N supplying power over the long-term through the build-up of mineralizable N and appears to be an effective management strategy for improving degraded soils, thus enhancing the productive capacity of agricultural ecosystems. However, accounting for N2O emissions associated with repeated fertilizer N applications is imperative for properly assessing the net global warming potential of any land management system

Heating of the molecular gas in the massive outflow of the local ultraluminous-infrared and radio-loud galaxy 4C12.50

We present a comparison of the molecular gas properties in the outflow vs. in the ambient medium of the local prototype radio-loud and ultraluminous-infrared galaxy 4C12.50 (IRAS13451+1232), using new data from the IRAM Plateau de Bure interferometer and 30m telescope, and the Herschel space telescope. Previous H_2 (0-0) S(1) and S(2) observations with the Spitzer space telescope had indicated that the warm (~400K) molecular gas in 4C12.50 is made up of a 1.4(+-0.2)x10^8 M_sun ambient reservoir and a 5.2(+-1.7)x10^7 M_sun outflow. The new CO(1-0) data cube indicates that the corresponding cold (25K) H_2 gas mass is 1.0(+-0.1)x10^10 M_sun for the ambient medium and <1.3x10^8 M_sun for the outflow, when using a CO-intensity-to-H_2-mass conversion factor alpha of 0.8 M_sun /(K km/s pc^2). The combined mass outflow rate is high, 230-800 M_sun/yr, but the amount of gas that could escape the galaxy is low. A potential inflow of gas from a 3.3(+-0.3)x10^8 M_sun tidal tail could moderate any mass loss. The mass ratio of warm-to-cold molecular gas is >= 30 times higher in the outflow than in the ambient medium, indicating that a non-negligible fraction of the accelerated gas is heated to temperatures at which star formation is inefficient. This conclusion is robust against the use of different alpha factor values, and/or different warm gas tracers (H_2 vs. H_2 plus CO): with the CO-probed gas mass being at least 40 times lower at 400K than at 25K, the total warm-to-cold mass ratio is always lower in the ambient gas than in the entrained gas. Heating of the molecular gas could facilitate the detection of new outflows in distant galaxies by enhancing their emission in intermediate rotational number CO lines.Comment: A&A, in pres

A 450-day light curve of the radio afterglow of GRB 970508: Fireball calorimetry

We report on the results of an extensive monitoring campaign of the radio afterglow of GRB 970508, lasting 450 days after the burst. The spectral and temporal radio behavior indicate that the fireball has undergone a transition to sub-relativistic expansion at t~100 days. This allows us to perform "calorimetry" of the explosion. The derived total energy, ~5\times 10^{50} erg, is well below the ~5\times 10^{51} erg inferred under the assumption of spherical symmetry from gamma-ray and early afterglow observations. A natural consequence of this result, which can also account for deviations at t<100 days from the spherical relativistic fireball model predictions, is that the fireball was initially a wide-angle jet of opening angle ~30 degrees. Our analysis also allows to determine the energy fractions carried by electrons and magnetic field, and the density of ambient medium surrounding the fireball. We find that during the sub-relativistic expansion electrons and magnetic field are close to equipartition, and that the density of the ambient medium is ~1/cm^3. The inferred density rules out the possibility that the fireball expands into a strongly non-uniform medium, as would be expected, e.g., in the case of a massive star progenitor.Comment: 33 pages, including 7 figures, submitted to Ap

Finite Action in d5 Gauged Supergravity and Dilatonic Conformal Anomaly for Dual Quantum Field Theory

Gauged supergravity (SG) with single scalar (dilaton) and arbitrary scalar potential is considered. Such dilatonic gravity describes special RG flows in extended SG where scalars lie in one-dimensional submanifold of total space. The surface counterterm and finite action for such gauged SG in three-, four- and five-dimensional asymptotically AdS space are derived. Using finite action and consistent gravitational stress tensor (local surface counterterm prescription) the regularized expressions for free energy, entropy and mass of d4 dilatonic AdS black hole are found. The same calculation is done within standard reference background subtraction. The dilaton-dependent conformal anomaly from d3 and d5 gauged SGs is calculated using AdS/CFT correspondence. Such anomaly should correspond to two- and four-dimensional dual quantum field theory which is classically (not exactly) conformally invariant, respectively. The candidate c-functions from d3 and d5 SGs are suggested. These c-functions which have fixed points in asymptoticaly AdS region are expressed in terms of dilatonic potential and they are positively defined and monotonic for number of potentials.Comment: LaTeX file, 46 pages, two appendixes and some clarifications are adde

The magnetic field structure in CTA 102 from high-resolution mm-VLBI observations during the flaring state in 2016-2017

CONTEXT: Investigating the magnetic field structure in the innermost regions of relativistic jets is fundamental to understanding the crucial physical processes giving rise to jet formation, as well as to their extraordinary radiation output up to γ-ray energies. AIMS: We study the magnetic field structure of the quasar CTA 102 with 3 and 7 mm VLBI polarimetric observations, reaching an unprecedented resolution (∼50 μas). We also investigate the variability and physical processes occurring in the source during the observing period, which coincides with a very active state of the source over the entire electromagnetic spectrum. METHODS: We perform the Faraday rotation analysis using 3 and 7 mm data and we compare the obtained rotation measure (RM) map with the polarization evolution in 7 mm VLBA images. We study the kinematics and variability at 7 mm and infer the physical parameters associated with variability. From the analysis of γ-ray and X-ray data, we compute a minimum Doppler factor value required to explain the observed high-energy emission. RESULTS: Faraday rotation analysis shows a gradient in RM with a maximum value of ∼6 × 104⁴ rad m⁻² and intrinsic electric vector position angles (EVPAs) oriented around the centroid of the core, suggesting the presence of large-scale helical magnetic fields. Such a magnetic field structure is also visible in 7 mm images when a new superluminal component is crossing the core region. The 7 mm EVPA orientation is different when the component is exiting the core or crossing a stationary feature at ∼0.1 mas. The interaction between the superluminal component and a recollimation shock at ∼0.1 mas could have triggered the multi-wavelength flares. The variability Doppler factor associated with such an interaction is large enough to explain the high-energy emission and the remarkable optical flare occurred very close in time.Accepted manuscrip

Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells

Previously, we have shown that epidermal growth factor receptor (EGFR)-selective delivery of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), by genetic fusion to antibody fragment scFv425, enhances the tumor-selective pro-apoptotic activity of sTRAIL. Insight into the respective contribution of the agonistic receptors TRAIL-R1 and TRAIL-R2 to TRAIL-induced apoptosis may provide a rational approach to further optimize TRAIL-based therapy. Recently, this issue has been investigated using sTRAIL mutants designed to selectively bind to either receptor. However, the relative contribution of the respective TRAIL receptors, in particular TRAIL-R1, in TRAIL signaling is still unresolved. Here, we fused scFv425 to designed sTRAIL mutant sTRAILmR1–5, reported to selectively activate TRAIL-R1, and investigated the therapeutic apoptotic activity of this novel fusion protein. EGFR-specific binding of scFv425:sTRAILmR1–5 potently induced apoptosis, which was superior to the apoptotic activity of scFv425:sTRAIL-wt and a nontargeted MOCK-scFv:sTRAILmR1–5. During cotreatment with cisplatin or the histone deacetylase inhibitor valproic acid, scFv425:sTRAILmR1–5 retained its superior pro-apoptotic activity compared to scFv425:sTRAIL-wt. However, in catching-type Enzyme-Linked ImmunoSorbent Assays with TRAIL-R1:Fc and TRAIL-R2:Fc, scFv425:sTRAILmR1–5 was found to not only bind to TRAIL-R1 but also to TRAIL-R2. Binding to TRAIL-R2 also had functional consequences because the apoptotic activity of scFv425:sTRAILmR1–5 was strongly inhibited by a TRAIL-R2 blocking monoclonal antibody. Moreover, scFv425:sTRAILmR1–5 retained apoptotic activity upon selective knockdown of TRAIL-R1 using small inhibitory RNA. Collectively, these data indicate that both agonistic TRAIL receptors are functionally involved in TRAIL signaling by scFv425:sTRAILmR1–5 in solid tumor cells. Moreover, the superior target cell-restricted apoptotic activity of scFv425:sTRAILmR1–5 indicates its therapeutic potential for EGFR-positive solid tumors

Characterization of a glycosphingolipid antigen defined by the monoclonal antibody MBr1 expressed in normal and neoplastic epithelial cells of human mammary gland

The antigen defined by a monoclonal antibody, MBr1, was found to be expressed in normal human mammary gland epithelia and human mammary carcinoma cells (Menard, S., Tagliabue, E., Canevari, S., Fossati, G., and Colnaghi, M. I. (1983) Cancer Res. 43, 1295-1300). The antigen has been isolated from breast cancer cell line MCF-7, which was used as immunogen, and its structure was determined by methylation analysis, NMR spectroscopy, direct probe mass spectrometry, and enzymatic degradation as identified below. Fuc alpha 1----2Gal beta 1----3GalNAc beta 1----3Gal alpha 1----4Gal beta 1----4Glc beta 1----1Cer The antibody cross-reacted weakly with fucosylasialo-GM1 (IV2FucGg4), which shares the same terminal sequence, Fuc alpha 1----2Gal beta 1----3GalNAc, with this antigen. However, various other structures, including lacto-series H structure (Fuc alpha 1----2 Gal beta 1----4/or 3GlcNAc beta 1----3Gal), did not show any reactivity with this antibody. Therefore, this antigen represents a blood group H antigen with a globo-series structure which is abundant in human teratocarcinoma (Kannagi, R., Levery, S. B., Ishigami, F., Hakomori, S., Shevinsky, L. H., Knowles, B. B., and Solter, D. (1983) J. Biol. Chem. 258, 8934-8942), although its presence must be limited in normal adult human tissue

ISO observations of a sample of Compact Steep Spectrum and GHz Peaked Spectrum Radio Galaxies

We present results from observations obtained with ISOPHOT, on board the ISO satellite, of a representative sample of seventeen CSS/GPS radio galaxies and of a control sample of sixteen extended radio galaxies spanning similar ranges in redshift (0.2 = 10^26 W/Hz). The observations have been performed at lambda = 60, 90, 174 and 200 microns. Seven of the CSS/GPS sources have detections >= 3 sigma at one or more wavelengths, one of which is detected at >= 5 sigma. By co-adding the data we have obtained average flux densities at the four wavelengths. We found no evidence that the FIR luminosities of the CSS/GPS sources are significantly different from those of the extended objects and therefore there is not any support for CSS/GPS sources being objects "frustrated" by an abnormally dense ambient medium. The two samples were then combined, providing FIR information on a new sample of radio galaxies at intermediate redshifts. We compare this information with what previously known from IRAS and discuss the average properties of radio galaxies in the redshift range 0.2 - 0.8. The FIR emission cannot be accounted for by extrapolation of the synchrotron radio spectrum and we attribute it to thermal dust emission. The average FIR luminosity is >= 6*10^11 L_sun. Over the observed frequency range the infrared spectrum can be described by a power law with spectral index alpha >~1.0 +/- 0.2. Assuming the emission to be due to dust, a range of temperatures is required, from >=80 K to \~25 K. The dust masses required to explain the FIR emission range from 5*10^5 M_sun for the hotter component up to 2*10^8 M_sun for the colder one. (abridged)Comment: Astronomy & Astrophysics, in press, 16 pages, 2 Figure