512 research outputs found

    Barriers to Physical Activity: Physical Activity in Military Employees; Barrier impact on Perceived Health

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    Much of the world faces a growing obesity epidemic. (pp92-97) The consequences of this serious problem are well established and potentially devastating. Conditions associated with an elevated body mass include diabetes, hypertension, coronary heart disease, and certain malignancies.(pp97-100), For many, obesity and elevated body mass are a consequence of decreased physical activity; industrial advancements (eg, convenient transportation, technological advancements, and decreased need for manual labor) have contributed to an overall decrease in physical activity worldwide

    Speech and Language Outcomes in Patients with Ankyloglossia Undergoing Frenulectomy: A Retrospective Pilot Study

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    Ankyloglossia is a controversial topic with no standardized treatment guidelines. A retrospective chart review was conducted to identify children who underwent lingual frenulectomy for speech and language impairment. Impairment severity was recorded pre- and postoperatively as mild, mild to moderate, moderate, moderate to severe, or severe. Variables were tested with chi-square analysis for their statistical relationship to improvements in speech and language. Children with preoperative moderate and moderate-to-severe speech and language impairment attained better speech and language outcomes after frenulectomy as compared with children with mild and mild-to-moderate impairment (100% vs 82%, P = .015). Sutured closure after frenulectomy was associated with better speech and language improvements (100% vs 83%, P = .033). One could consider observation of patients with mild and mild-to-moderate speech and language impairments. Sutured closure might result in better improvements in speech and language impairments. This pilot study sheds light on the potential impact of a larger study currently underway

    Nonlocal mechanism for cluster synchronization in neural circuits

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    The interplay between the topology of cortical circuits and synchronized activity modes in distinct cortical areas is a key enigma in neuroscience. We present a new nonlocal mechanism governing the periodic activity mode: the greatest common divisor (GCD) of network loops. For a stimulus to one node, the network splits into GCD-clusters in which cluster neurons are in zero-lag synchronization. For complex external stimuli, the number of clusters can be any common divisor. The synchronized mode and the transients to synchronization pinpoint the type of external stimuli. The findings, supported by an information mixing argument and simulations of Hodgkin Huxley population dynamic networks with unidirectional connectivity and synaptic noise, call for reexamining sources of correlated activity in cortex and shorter information processing time scales.Comment: 8 pges, 6 figure

    The Portland Basin; a (big) river runs through it

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    ABSTRACT Metropolitan Portland, Oregon, USA, lies within a small Neogene to Holocene basin in the forearc of the Cascadia subduction system. Although the basin owes its existence and structural development to its convergent-margin tectonic setting, the stratigraphic architecture of basin-fill deposits chiefly reflects its physiographic position along the lower reaches of the continental-scale Columbia River system. As a result of this globally unique setting, the basin preserves a complex record of aggradation and incision in response to distant as well as local tectonic, volcanic, and climatic events. Voluminous flood basalts, continental and locally derived sediment and volcanic debris, and catastrophic flood deposits all accumulated in an area influenced by contemporaneous tectonic deformation and variations in regional and local base level

    A Feasibility Study for An Integrated Approach to Fall Prevention in Community Care: Stay Up and Active in Orange County

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    Introduction: Falls amongst persons over 60 present significant risks for serious injury or debility. Falls place burdens on Emergency Medical Services (EMS), hospitals, and the adults themselves. Recognizing a need to provide interventions to minimize risk, Orange County Emergency Services (OCES), the Orange County Department on Aging (OCDoA), and the University of North Carolina at Chapel Hill (UNC) partnered to create the Stay Up and Active Program (SUAA). Methods: A streamlined workflow algorithm between the OCES and OCDoA was created and employed to provide falls risk assessment and necessary services. Qualitative techniques were used to assess the need for such a program and its potential impact. A subset of individuals were interviewed three months after the intervention to assess the impact of the intervention on their fall risk. Results: In the first seven months, 478 instances of individuals who called OCES screened positive for falls risk. Of the 478 positive screenings, 55 individuals were identified as having received more than one positive fall screen due to multiple calls. The maximum number of positive screenings by one individual was 14. More women (61.3%) than men screened positive for fall risk. Individuals 88 years of age (6.9%) represented the mode of the individuals with positive screens. Nineteen (4.0%) people who called OCES and received the intervention completed a three month follow up survey. Of the nineteen, 86% (n=16) reported no recurrent fall.Conclusion: The number of individuals who screened positive supports the need for early identification and intervention through EMS. This program identified several challenges connecting older adults with services already available to keep them independent which provided insight to all stakeholders regarding factors that inhibit the program’s success. The program evaluation should continue to provide suggestions for improvement and ensure sustainability

    Adjusting magnetic nanostructures for high-performance magnetic sensors

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    The magnetic properties of the soft ferromagnetic layer in magnetic tunnel junctions are one of key factors to determine the performance of magnetoresistance sensors. We use a three-step orthogonal annealing procedure to modify the nanostructures of the free layer in the magnetic tunnel junction to control features such as magnetization reversal, coercivity, exchange field, and tunnel magnetoresistance ratio. We present a sensor with an improved sensitivity as high as 3944%/mT. This magnetic sensor only dissipates 200 lW of power while operating under an applied voltage of 1V

    Direct In Vivo Cell Lineage Analysis in the Retrorsine and 2AAF Models of Liver Injury after Genetic Labeling in Adult and Newborn Rats

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    BACKGROUNDS AND AIMS:When hepatocyte proliferation is impaired, liver regeneration proceeds from the division of non parenchymal hepatocyte progenitors. Oval cells and Small Hepatocyte-like Progenitor Cells (SHPCs) represent the two most studied examples of such epithelial cells with putative stem cell capacity. In the present study we wished to compare the origin of SHPCs proliferating after retrorsine administration to the one of oval cells observed after 2-Acetyl-Amino fluorene (2-AAF) treatment. METHODOLOGY/PRINCIPAL FINDINGS:We used retroviral-mediated nlslacZ genetic labeling of dividing cells to study the fate of cells in the liver. Labeling was performed either in adult rats before treatment or in newborn animals. Labeled cells were identified and characterised by immunohistochemistry. In adult-labeled animals, labeling was restricted to mature hepatocytes. Retrorsine treatment did not modify the overall number of labeled cells in the liver whereas after 2-AAF administration unlabeled oval cells were recorded and the total number of labeled cells decreased significantly. When labeling was performed in newborn rats, results after retrorsine administration were identical to those obtained in adult-labeled rats. In contrast, in the 2-AAF regimen numerous labeled oval cells were present and were able to generate new labeled hepatocytes. Furthermore, we also observed labeled biliary tracts in 2-AAF treated rats. CONCLUSIONS:Our results strongly suggest that SHPCs are derived from hepatocytes and we confirm that SHPCs and oval cells do not share the same origin. We also show that hepatic progenitors are labeled in newborn rats suggesting future directions for in vivo lineage studies

    Female firesetters: gender associated psychological and psychopathological features

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    Objective: Female firesetters are reported to commit nearly a third of deliberately set fires, yet there are limited studies examining the characteristics that distinguish them from suitable comparison groups. The aim of this study is to compare incarcerated female firesetters with incarcerated male firesetters and female offender controls on psychopathological and psychological features that could be targeted via therapeutic interventions. Method: Sixty-five female firesetters, 128 male firesetters, and 63 female offenders were recruited from the prison estate. Participants completed a battery of validated tools assessing psychiatric traits and psychological characteristics (i.e., inappropriate fire interest, emotion/self-regulation, social competence, self-concept, offense-supportive attitudes, and boredom proneness) highlighted in the existing literature. Results: Major depression and an internal locus of control distinguished female firesetters from male firesetters. Alcohol dependence, serious/problematic fire interest, and more effective anger regulation distinguished female firesetters from the female offender control group. Conclusions: This is the first study to examine differences between female firesetters, male firesetters, and female control offenders on both psychopathological features and psychological traits. These findings highlight the gender-specific and offence-specific needs of female firesetters that clinicians need to consider when implementing programs that ensure client responsivity. Keywords: firesetting, arson, psychopathology, female offender
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