Relativistic effects in Lyman-α forest

We present the calculation of the Lyman-alpha (Lyman-$\alpha$) transmitted flux fluctuations with full relativistic corrections to the first order. Even though several studies exist on relativistic effects in galaxy clustering, this is the first study to extend the formalism to a different tracer of underlying matter at unique redshift range ($z=2-5$). Furthermore, we show a comprehensive application of our calculations of the Quasar-Lyman-$\alpha$ cross-correlation function. Our results indicate that the signal of relativistic effects is sizeable at Baryonic Acoustic Oscillation (BAO) scale mainly due to the large difference in density bias factors of our tracers. We construct an observable, the anti-symmetric part of the cross-correlation function, that is dominated by the relativistic signal and offers a new way to measure the relativistic terms at relatively small scales. The analysis shows that relativistic effects are important when considering cross-correlations between tracers with very different biases, and should be included in the data analysis of the current and future surveys. Moreover, the idea presented in this paper is highly complementary to other techniques and observable trying to isolate the effect of the relativistic corrections and thus test the validity of the theory of gravity beyond the Newtonian regime

Rotation of the CMB polarization by foreground lensing

We investigate the weak lensing corrections to the CMB polarization anisotropies. We concentrate on the effect of rotation and show that the rotation of polarisation is a true physical effect which has to be taken into account at second order in perturbation theory. We clarify inconsistencies on the treatment of this rotation in the recent literature. We also show that at first order in perturbation theory there is no rotation of polarisation also for vector and tensor modes

Non-Gaussianities due to Relativistic Corrections to the Observed Galaxy Bispectrum

High-precision constraints on primordial non-Gaussianity (PNG) will significantly improve our understanding of the physics of the early universe. Among all the subtleties in using large scale structure observables to constrain PNG, accounting for relativistic corrections to the clustering statistics is particularly important for the upcoming galaxy surveys covering progressively larger fraction of the sky. We focus on relativistic projection effects due to the fact that we observe the galaxies through the light that reaches the telescope on perturbed geodesics. These projection effects can give rise to an effective $f_{\rm NL}$ that can be misinterpreted as the primordial non-Gaussianity signal and hence is a systematic to be carefully computed and accounted for in modelling of the bispectrum. We develop the technique to properly account for relativistic effects in terms of purely observable quantities, namely angles and redshifts. We give some examples by applying this approach to a subset of the contributions to the tree-level bispectrum of the observed galaxy number counts calculated within perturbation theory and estimate the corresponding non-Gaussianity parameter, $f_{\rm NL}$, for the local, equilateral and orthogonal shapes. For the local shape, we also compute the local non-Gaussianity resulting from terms obtained using the consistency relation for observed number counts. Our goal here is not to give a precise estimate of $f_{\rm NL}$ for each shape but rather we aim to provide a scheme to compute the non-Gaussian contamination due to relativistic projection effects. For the terms considered in this work, we obtain contamination of $f_{\rm NL}^{\rm loc} \sim {\mathcal O}(1)$.Comment: 31 pages, 6 figures, Typos corrected to match the published version in JCA

Time-dependent moments from partial differential equations and the time-dependent set of atoms

We study the time-dependent moments $s_\alpha(t) = \int x^\alpha\cdot f(x,t)~\mathrm{d} x$ of the solution $f$ of the partial differential equation $\partial_t f = \nu\Delta f + g\cdot\nabla f + h\cdot f$ with initial Schwartz function data $f_0\in\mathcal{S}(\mathbb{R}^n)$. At first we describe the dual action on the polynomials, i.e., the time-evolution of $f$ is completely moved to the polynomial side $s_\alpha(t) = \int p(x,t)\cdot f_0(x)~\mathrm{d} x$. We investigate the special case of the heat equation. We find that several non-negative polynomials which are not sums of squares become sums of squares under the heat equation in finite time. Finally, we solve the problem of moving atoms under the equation $\partial_t f = g\cdot\nabla f + h\cdot f$ with $f_0 = \mu_0$ being a finitely atomic measure. We find that in the time evolution $\mu_t = \sum_{i=1}^k c_i(t)\cdot \delta_{x_i(t)}$ the atom positions $x_i(t)$ are governed only by the transport term $g\cdot\nabla$ and that the time-dependent coefficients $c_i(t)$ have an analytic solution depending on $x_i(t)$

Meissner to vortex phase transition in a two-leg ladder in artificial gauge field

International audienceWe consider a two-leg boson ladder in artificial gauge field with hard-core intraleg and negligible interleg interactions. Using numerical simulations based on the Density Matrix Renormalization Group (DMRG) algorithm, combined with a bosonization approach, we study its commensurate-incommensurate transition to a vortex phase at a critical flux. We discuss the finite-size scaling behavior of the longitudinal current near the transition. For weak interchain bo-son hopping, the finite size scaling is in agreement with the predictions from bosonization

Characterization of chenopodin isoforms from quinoa seeds and assessment of their potential anti-inflammatory activity in Caco-2 cells

Several food-derived molecules, including proteins and peptides, can show bioactivities toward the promotion of well-being and disease prevention in humans. There is still a lack of information about the potential effects on immune and inflammatory responses in mammalian cells following the ingestion of seed storage proteins. This study, for the first time, describes the potential immunomodulation capacity of chenopodin, the major protein component of quinoa seeds. After characterizing the molecular features of the purified protein, we were able to separate two different forms of chenopodin, indicated as LcC (Low charge Chenopodin, 30% of total chenopodin) and HcC (High charge Chenopodin, 70% of total chenopodin). The biological effects of LcC and HcC were investigated by measuring NF-\u3baB activation and IL-8 expression studies in undifferentiated Caco-2 cells. Inflammation was elicited using IL-1\u3b2. The results indicate that LcC and HcC show potential anti-inflammatory activities in an intestinal cell model, and that the proteins can act differently, depending on their structural features. Furthermore, the molecular mechanisms of action and the structural/functional relationships of the protein at the basis of the observed bioactivity were investigated using in silico analyses and structural predictions

Vitality forms processing in the insula during action observation: a multivoxel pattern analysis

Observing how an action is done by others allows the observer to understand the cognitive and emotion state of the agent. This information, carried by the kinematics of the observed action, has been defined by Daniel Stern \u201cvitality forms\u201d. The expression and the capacity to understand the vitality forms is already present in infants, a finding indicating their importance for the development of social attunement. It has been proposed that, well before developing linguistic abilities, infants are actively engaged in non-verbal exchanges with their caregivers. This ability denotes a primordial way to relate to and understand others and presumably represents a constitutive element of interpersonal relations, namely intersubjectivity. In the present neuroimaging (fMRI) study we presented participants with videos showing hand actions performed with different velocities and asked them to judge their vitality form (gentle, neutral, rude) or their velocity (slow, medium, fast). Previous studies showed that the dorso-central insula is selectively active both during vitality form observation and execution. The aim of the present study was to assess, using multi-voxel pattern analysis (MVPA), whether in the insula there are voxels discriminating vitality form from velocity. Results showed that, consistently across subjects, in the dorso-central sector of the insula there are voxels selectively tuned to vitality forms. Supporting previous findings, these results confirm that the dorso-central insula is involved in processing the vitality forms of an action, both when carryied out in the first person and when observed in other individuals. This supports the idea that the understanding of others' behavior in terms of affective content is mediated by an automatic activation system that allows the recipient to tune in and respond to another individual's emotional state without necessarily having "formal" knowledge of what is being observed. As argued by Stern, this process would allow a synchronization with the behavior of others that underlies the first relational forms developing in early childhood

Patent ductus arteriosus (also non-hemodynamically significant) correlates with poor outcomes in very low birth weight infants. A multicenter cohort study

Objectives To standardize the diagnosis of patent ductus arteriosus (PDA) and report its association with adverse neonatal outcomes in very low birth weight infants (VLBW, birth weight < 1500 g). Study design A multicenter prospective observational study was conducted in Emilia Romagna from March 2018 to October 2019. The association between ultrasound grading of PDA and adverse neonatal outcomes was evaluated after correction for gestational age. A diagnosis of hemodynamically significant PDA (hsPDA) was established when the PDA diameter was ≥ 1.6 mm at the pulmonary end with growing or pulsatile flow pattern, and at least 2 of 3 indexes of pulmonary overcirculation and/or systemic hypoperfusion were present. Results 218 VLBW infants were included. Among infants treated for PDA closure in the first postnatal week, up to 40% did not have hsPDA on ultrasound, but experienced clinical worsening. The risk of death was 15 times higher among neonates with non-hemodynamically significant PDA (non-hsPDA) compared to neonates with no PDA. In contrast, the risk of death was similar between neonates with hsPDA and neonates with no PDA. The occurrence of BPD was 6-fold higher among neonates with hsPDA, with no apparent beneficial role of early treatment for PDA closure. The risk of IVH (grade ≥ 3) and ROP (grade ≥ 3) increased by 8.7-fold and 18-fold, respectively, when both systemic hypoperfusion and pulmonary overcirculation were present in hsPDA. Conclusions The increased risk of mortality in neonates with non-hsPDA underscores the potential inadequacy of criteria for defining hsPDA within the first 3 postnatal days (as they may be adversely affected by other clinically severe factors, i.e. persistent pulmonary hypertension and mechanical ventilation). Parameters such as length, diameter, and morphology may serve as more suitable ultrasound indicators during this period, to be combined with clinical data for individualized management. Additionally, BPD, IVH (grade ≥ 3) and ROP (grade ≥ 3) are associated with hsPDA. The existence of an optimal timeframe for closing PDA to minimize these adverse neonatal outcomes remains uncertain

The impact of multidisciplinary team management on outcome of hepatic resection in liver-limited colorectal metastases

Hepatic resection is the gold standard treatment for patients affected by liver-limited colorectal metastases. Reports addressing the impact of multidisciplinary team (MDT) evaluation on survival are controversial. The aim of this study was to evaluate the benefit of MDT management in these patients in our Institution experience. The objective of the analysis was to compare survivals of patients managed within our MDT (MDT cohort) to those of patients referred to surgery from other hospitals without MDT discussion (non-MDT cohort). Of the 523 patients, 229 were included in the MDT cohort and 294 in the non-MDT cohort. No difference between the two groups was found in terms of median overall survival (52.5 vs 53.6 months; HR 1.13; 95% CI, 0.88–1.45; p = 0.344). In the MDT cohort there was a higher number of metastases (4.5 vs 2.7; p < 0.0001). The median duration of chemotherapy was lower in MDT patients (8 vs 10 cycles; p < 0.001). Post-operative morbidity was lower in the MDT cohort (6.2 vs 21.5%; p < 0.001). One hundred and ninety-seven patients in each group were matched by propensity score and no significant difference was observed between the two groups in terms of OS and DFS. Our study does not demonstrate a survival benefit from MDT management, but it allows surgery to patients with a more advanced disease. MDT assessment reduces the median duration of chemotherapy and post-operative morbidities