207 research outputs found
WISE/NEOWISE Observations of the Jovian Trojans: Preliminary Results
We present the preliminary analysis of over 1739 known and 349 candidate
Jovian Trojans observed by the NEOWISE component of the Wide-field Infrared
Survey Explorer (WISE). With this survey the available diameters, albedos and
beaming parameters for the Jovian Trojans have been increased by more than an
order of magnitude compared to previous surveys. We find that the Jovian Trojan
population is very homogenous for sizes larger than km (close to the
detection limit of WISE for these objects). The observed sample consists almost
exclusively of low albedo objects, having a mean albedo value of .
The beaming parameter was also derived for a large fraction of the observed
sample, and it is also very homogenous with an observed mean value of
. Preliminary debiasing of the survey shows our observed sample is
consistent with the leading cloud containing more objects than the trailing
cloud. We estimate the fraction to be N(leading)/N(trailing) , lower than the value derived by others.Comment: Accepted for publication in Astrophysical Journal. Electronic table
will be available at the publishers websit
American Society of Hematology 2020 guidelines for sickle cell disease: Prevention, diagnosis, and treatment of cerebrovascular disease in children and adults
BACKGROUND: Central nervous system (CNS) complications are among the most common, devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan.OBJECTIVE: These evidence-based guidelines of the American Society of Hematology are intended to support the SCD community in decisions about prevention, diagnosis, and treatment of the most common neurological morbidities in SCD.METHODS: The Mayo Evidence-Based Practice Research Program supported the guideline development process, including updating or performing systematic evidence reviews. The panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, including GRADE evidence-to-decision frameworks, to assess evidence and make recommendations.RESULTS: The panel placed a higher value on maintaining cognitive function than on being alive with significantly less than baseline cognitive function. The panel developed 19 recommendations with evidence-based strategies to prevent, diagnose, and treat CNS complications of SCD in low-middle- and high-income settings.CONCLUSIONS: Three of 19 recommendations immediately impact clinical care. These recommendations include: use of transcranial Doppler ultrasound screening and hydroxyurea for primary stroke prevention in children with hemoglobin SS (HbSS) and hemoglobin Sβ0 (HbSβ0) thalassemia living in low-middle-income settings; surveillance for developmental delay, cognitive impairments, and neurodevelopmental disorders in children; and use of magnetic resonance imaging of the brain without sedation to detect silent cerebral infarcts at least once in early-school-age children and once in adults with HbSS or HbSβ0 thalassemia. Individuals with SCD, their family members, and clinicians should become aware of and implement these recommendations to reduce the burden of CNS complications in children and adults with SCD.</p
Main Belt Asteroids with WISE/NEOWISE I: Preliminary Albedos and Diameters
We present initial results from the Wide-field Infrared Survey Explorer
(WISE), a four-band all-sky thermal infrared survey that produces data well
suited to measuring the physical properties of asteroids, and the NEOWISE
enhancement to the WISE mission allowing for detailed study of Solar system
objects. Using a NEATM thermal model fitting routine we compute diameters for
over 100,000 Main Belt asteroids from their IR thermal flux, with errors better
than 10%. We then incorporate literature values of visible measurements (in the
form of the H absolute magnitude) to determine albedos. Using these data we
investigate the albedo and diameter distributions of the Main Belt. As observed
previously, we find a change in the average albedo when comparing the inner,
middle, and outer portions of the Main Belt. We also confirm that the albedo
distribution of each region is strongly bimodal. We observe groupings of
objects with similar albedos in regions of the Main Belt associated with
dynamical breakup families. Asteroid families typically show a characteristic
albedo for all members, but there are notable exceptions to this. This paper is
the first look at the Main Belt asteroids in the WISE data, and only represents
the preliminary, observed raw size and albedo distributions for the populations
considered. These distributions are subject to survey biases inherent to the
NEOWISE dataset and cannot yet be interpreted as describing the true
populations; the debiased size and albedo distributions will be the subject of
the next paper in this series.Comment: Accepted to ApJ. Online table to also appear on the publisher's
websit
Adapting Medical Guidelines to Be Patient-centered Using a Patient-driven Process for Individuals With Sickle Cell Disease and Their Caregivers
Background: Evidence-based guidelines for sickle cell disease (SCD) health maintenance and management have been developed for primary health care providers, but not for individuals with SCD. To improve the quality of care delivered to individuals with SCD and their caregivers, the main purposes of this study were to: (1) understand the desire for patient-centered guidelines among the SCD community; and (2) adapt guideline material to be patient-centered using community-engagement strategies involving health care providers, community -based organizations, and individuals with the disease.
Methods: From May–December 2016, a volunteer sample of 107 individuals with SCD and their caregivers gave feedback at community forums (n = 64) and community listening sessions (n = 43) about technology use for health information and desire for SCD-related guidelines. A team of community research partners consisting of community stakeholders, individuals living with SCD, and providers and researchers (experts) in SCD at nine institutions adapted guidelines to be patient-centered based on the following criteria: (1) understandable, (2) actionable, and (3) useful.
Results: In community forums (n = 64), almost all participants (91%) wanted direct access to the content of the guidelines. Participants wanted guidelines in more than one format including paper (73%) and mobile devices (79%). Guidelines were adapted to be patient-centered. After multiple iterations of feedback, 100% of participants said the guidelines were understandable, most (88%) said they were actionable, and everyone (100%) would use these adapted guidelines to discuss their medical care with their health care providers.
Conclusions: Individuals with SCD and their caregivers want access to guidelines through multiple channels, including technology. Guidelines written for health care providers can be adapted to be patient-centered using Community-engaged research involving providers and patients. These patient-centered guidelines provide a framework for patients to discuss their medical care with their health care providers
NEOWISE Observations of Near-Earth Objects: Preliminary Results
With the NEOWISE portion of the \emph{Wide-field Infrared Survey Explorer}
(WISE) project, we have carried out a highly uniform survey of the near-Earth
object (NEO) population at thermal infrared wavelengths ranging from 3 to 22
m, allowing us to refine estimates of their numbers, sizes, and albedos.
The NEOWISE survey detected NEOs the same way whether they were previously
known or not, subject to the availability of ground-based follow-up
observations, resulting in the discovery of more than 130 new NEOs. The
survey's uniformity in sensitivity, observing cadence, and image quality have
permitted extrapolation of the 428 near-Earth asteroids (NEAs) detected by
NEOWISE during the fully cryogenic portion of the WISE mission to the larger
population. We find that there are 98119 NEAs larger than 1 km and
20,5003000 NEAs larger than 100 m. We show that the Spaceguard goal of
detecting 90% of all 1 km NEAs has been met, and that the cumulative size
distribution is best represented by a broken power law with a slope of
1.320.14 below 1.5 km. This power law slope produces 1,900
NEAs with 140 m. Although previous studies predict another break in the
cumulative size distribution below 50-100 m, resulting in an increase in
the number of NEOs in this size range and smaller, we did not detect enough
objects to comment on this increase. The overall number for the NEA population
between 100-1000 m are lower than previous estimates. The numbers of near-Earth
comets will be the subject of future work.Comment: Accepted to Ap
Molar pregnancy and childhood cancer: a population-based linkage study from Denmark
We observed a relative risk of 1.40 (95% confidence interval; 0.86–2.16) for cancers diagnosed under the age 20 in 6192 offspring of 3431 mothers with a molar pregnancy, indicating it is not a major determinant of childhood cancer
WISE/NEOWISE Observations of the Hilda Population: Preliminary Results
We present the preliminary analysis of 1023 known asteroids in the Hilda
region of the Solar System observed by the NEOWISE component of the Wide-field
Infrared Survey Explorer (WISE). The sizes of the Hildas observed range from
km. We find no size - albedo dependency as reported by other
projects. The albedos of our sample are low, with a weighted mean value , for all sizes sampled by the NEOWISE survey. We observed a
significant fraction of the objects in the two known collisional families in
the Hilda population. It is found that the Hilda collisional family is
brighter, with weighted mean albedo of , than the general
population and dominated by D-type asteroids, while the Schubart collisional
family is darker, with weighted mean albedo of (). Using
the reflected sunlight in the two shortest WISE bandpasses we are able to
derive a method for taxonomic classification of of the Hildas
detected in the NEOWISE survey. For the Hildas with diameter larger than 30km
there are D-type asteroids and C-/P-type
asteroids (with the majority of these being P-types).Comment: Accepted for publication in Astrophysical Journal. Electronic table
to be published on the publishers websit
Yoga after Stroke Leads to Multiple Physical Improvements
poster abstractMethods: Forty-seven individuals with chronic stroke were recruited and randomized 3:1 to yoga or waitlist control (usual care). The yoga group completed one hour yoga sessions twice a week for 8 weeks. Yoga was taught by a yoga therapist and included modified physical postures in seated, standing, and supine positions and included yoga breathing, bilateral movements, concluding with relaxation.
Assessments before and after the 8 weeks included: flexibility via passive range of motion (PROM) for the hamstrings (HS) and active range of motion (AROM) for hip flexion, cervical rotation, and cervical lateral flexion; strength with the chair to stand and arm curl and hip flexion manual muscle test; and walking capacity with the 6 minute walk test. We compared groups with a t-test/Mann Whitney. We used paired t-tests/Wilcoxon non-parametric tests to compare baseline and 8-week data
Genomic imprinting and assisted reproduction
Imprinted genes exhibit a parent-of-origin specific pattern of expression. Such genes have been shown to be targets of molecular defects in particular genetic syndromes such as Beckwith-Wiedemann and Angelman syndromes. Recent reports have raised concern about the possibility that assisted reproduction techniques, such as in vitro fertilization or intracytoplasmic sperm injection, might cause genomic imprinting disorders. The number of reported cases of those disorders is still too small to draw firm conclusions and the safety of these widely used assisted reproduction techniques needs to be further evaluated
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