556 research outputs found

    Guidance of a low l/d vehicle entering the earth's atmosphere at speeds up to 50,000 feet per second

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    Guidance of low lift-drag ratio vehicle during earth atmosphere reentr

    Pitfalls in Merger Analysis: The Dirty Dozen

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    Merger Pitfalls in Practice: Three Case Studies

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    Signaling about norms: socialization under strategic uncertainty

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    We consider a signaling model where adults possess information about the dominant social norm. Children want to conform to whatever norm is dominant but, lacking accurate information, take the observed behavior of their parent as representative. We show that this causes a signaling distortion in adult behavior, even in the absence of conflicts of interest. Parents adopt attitudes that encourage their children to behave in a socially safe way, i.e. the way that would be optimal under maximum uncertainty about the prevailing social norm. We discuss applications to sexual attitudes, collective reputation, and trust

    Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development

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    Spontaneous bursts of electrical activity in the developing auditory system arise within the cochlea before hearing onset and propagate through future sound-processing circuits of the brain to promote maturation of auditory neurons. Studies in isolated cochleae revealed that this intrinsically generated activity is initiated by ATP release from inner supporting cells (ISCs), resulting in activation of purinergic autoreceptors, K+ efflux, and subsequent depolarization of inner hair cells. However, it is unknown when this activity emerges or whether different mechanisms induce activity during distinct stages of development. Here we show that spontaneous electrical activity in mouse cochlea from both sexes emerges within ISCs during the late embryonic period, preceding the onset of spontaneous correlated activity in inner hair cells and spiral ganglion neurons, which begins at birth and follows a base to apex developmental gradient. At all developmental ages, pharmacological inhibition of P2Y1 purinergic receptors dramatically reduced spontaneous activity in these three cell types. Moreover, in vivo imaging within the inferior colliculus revealed that auditory neurons within future isofrequency zones exhibit coordinated neural activity at birth. The frequency of these discrete bursts increased progressively during the postnatal prehearing period yet remained dependent on P2RY1. Analysis of mice with disrupted cholinergic signaling in the cochlea indicate that this efferent input modulates, rather than initiates, spontaneous activity before hearing onset. Thus, the auditory system uses a consistent mechanism involving ATP release from ISCs and activation of P2RY1 autoreceptors to elicit coordinated excitation of neurons that will process similar frequencies of sound.Fil: Babola, Travis A.. University Johns Hopkins; Estados UnidosFil: Li, Sally. University Johns Hopkins; Estados UnidosFil: Wang, Zhirong. University Of Georgetown; Estados UnidosFil: Kersbergen, Calvin J.. University Johns Hopkins; Estados UnidosFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto de Investigaciones en IngenierĂ­a GenĂŠtica y BiologĂ­a Molecular "Dr. HĂŠctor N. Torres"; ArgentinaFil: Coate, Thomas M.. University Johns Hopkins; Estados UnidosFil: Bergles, Dwight E.. University Johns Hopkins; Estados Unido

    Self-fulfilling regression and statistical discrimination

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    This paper provides a simple model which explains that statistical discrimination can arise in a purely self‐fulfilling manner. The story is as follows. (i) At the point of hiring, employers cannot observe workers’ productivities but can observe only their signals, such as test scores, and under perfect competition they pay for expected labor productivity conditional on signal observation, based on their belief about return to signal. (ii) Given the employers’ belief, workers choose an effort level, which affects the joint probability distribution over productivity–signal pairs. (iii) In equilibrium, the employers’ belief proves to be statistically consistent. We show that there may be multiple equilibria, and that equilibrium selection has nothing to do with economic fundamentals

    Computing welfare losses from data under imperfect competition with heterogeneous goods

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    We study the percentage of welfare losses (PWL) yielded by imperfect competition under product differentiation. When demand is linear, if prices, outputs, costs and the number of firms can be observed, PWL is arbitrary in both Cournot and Bertrand equilibria. If in addition, the elasticity of demand (resp. cross elasticity of demand) is known, we can calculate PWL in Cournot (resp. Bertrand) equilibrium. When demand is isoelastic and there are many firms, PWL can be computed from prices, outputs, costs and the number of .rms. In all these cases we find that price-marginal cost margins and demand elasticities may influence PWL in a counterintuitive way. We also provide conditions under which PWL increases or decreases with concentration
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