Passive Optical Sample Assembly (POSA) for STS-1 quick look post-mission report

A passively deployed array of contamination-sensitive samples was mounted and flown in the cargo bay of the space shuttle Columbia during the first orbital flight test. A similar unit was mounted in a different location in the cargo bay at Dryden Flight Research Center during the postflight operations there prior to the ferry flight return of Columbia to Kennedy Space Center. The samples in both POSA arrays were subjected to a series of optical and analytical measurements prior to delivery for installation in the cargo bay and after retrieval of the flight hardware. A quick-look summary of the results of a comparison of the series of measurements is presented

Identifying long cycles in finite alternating and symmetric groups acting on subsets

Let $H$ be a permutation group on a set $\Lambda$, which is permutationally isomorphic to a finite alternating or symmetric group $A_n$ or $S_n$ acting on the $k$-element subsets of points from $\{1,\ldots,n\}$, for some arbitrary but fixed $k$. Suppose moreover that no isomorphism with this action is known. We show that key elements of $H$ needed to construct such an isomorphism $\varphi$, such as those whose image under $\varphi$ is an $n$-cycle or $(n-1)$-cycle, can be recognised with high probability by the lengths of just four of their cycles in $\Lambda$.Comment: 45 page

Estimating Yield Curves by Kernel Smoothing Methods

We introduce a new method for the estimation of discount functions, yield curves and forward curves for coupon bonds. Our approach is nonparametric and does not assume a particular functional form for the discount function although we do show how to impose various important restrictions in the estimation. Our method is based on kernel smoothing and is defined as the minimum of some localized population moment condition. The solution to the sample problem is not explicit and our estimation procedure is iterative, rather like the backfitting method of estimating additive nonparametric models. We establish the asymptotic normality of our methods using the asymptotic representation of our estimator as an infinite series with declining coefficients. The rate of convergence is standard for one dimensional nonparametric regression.Coupon bonds; forward curve; Hilbert space; local linear; nonparametric regression; yield curve

Passive Optical Sample Assembly (POSA)

A Passive Optical Sample Assembly (POSA) unit was mounted and flown in the cargo bay of the space shuttle Columbia during the first Orbital Flight Test (OFT-1). A similar unit was mounted in a different location in the cargo bay during the postflight operations. The samples in both POSA arrays were subjected to a series of optical and analytical measurements prior to delivery for installation in the cargo bay and after retrieval of the flight hardware. The final results of a comparison of the two series of measurements are presented. These STS-1 results are based on data obtained from only a portion of one of the ten Induced Environment Contamination Monitor instruments to be flown on several shuttle flights beginning with STS-2. These limited results do not indicate shuttle contamination levels in excess of those anticipated

Measurement of the Zero Crossing in a Feshbach Resonance of Fermionic 6-Li

We measure a zero crossing in the scattering length of a mixture of the two lowest hyperfine states of 6-Li. To locate the zero crossing, we monitor the decrease in temperature and atom number arising from evaporation in a CO2 laser trap as a function of magnetic field B. The temperature decrease and atom loss are minimized for B=528(4) G, consistent with no evaporation. We also present preliminary calculations using potentials that have been constrained by the measured zero crossing and locate a broad Feshbach resonance at approximately 860 G, in agreement with previous theoretical predictions. In addition, our theoretical model predicts a second and much narrower Feshbach resonance near 550 G.Comment: Five pages, four figure

Paper Session III-B - A Combined Probabilistic and Expert System Approach for Assigning Repair Start-Times at the NASA Shuttle Logistics Depot

The NASA Shuttle Logistics Depot (NSLD) is tasked with the responsibility for repair and manufacture of Line Replaceable Unit (LRU) hardware and components to support the Space Shuttle Orbiter. Due to shrinking budgets, cost effective repair of LRUs becomes a primary objective. To achieve this objective, it is imperative that resources can be assigned to those LRUs which have the greatest expectation of being needed as a spare. Forecasting the times at which spares are needed requires consideration of many significant factors including, for example, failure rate, flight rate, spares availability, and desired level of support, among others. This paper summarizes the results of the research and development work that has been accomplished in producing an automated system for assisting in the assignment of effective repair start-times for LRUs at the NSLD. This system, called the Repair Start-time Assignment System (RSAS), combines probabilistic modeling and expert system technology to generate an expected future need date. The result is a mathematically calculated value that has been adjusted heuristically to produce a date for beginning the repair that has significantly greater confidence (in the sense that a desired probability of support is assured) than dates produced using other techniques. Since an important output of RSAS is the longest repair turn-around time that will ensure a desired probability of support, RSAS has the potential for being applied to operations at any repair depot where spares are on-hand and repair start-times are of interest. In addition, RSAS incorporates tenants of Just-In-Time (JIT) techniques in the connotation that the latest repair start-time (i.e., the latest time at which repair resources must be committed) may be calculated for every failed unit. This could aid in reducing the spares inventory for certain items, without significantly increasing the risk of unsatisfied demand

Do toe blood pressures predict healing after minor lower limb amputation in people with diabetes? : a systematic review and meta-analysis

Purpose of study: To investigate toe systolic blood pressure and/or toe-brachial pressure index in predicting healing post minor diabetic foot amputations. Key methods: A systematic search of EMBASE and PubMed (including Medline and The Cochrane Library) was conducted from database inception to 9 March 2020. Two authors independently reviewed and selected relevant studies. Quality was assessed with a modified Critical Appraisal Skill Programme checklist. Main results: Ten studies met the inclusion criteria. Nine studies investigating toe systolic blood pressure reported healing occurred at mean toe systolic blood pressure values ⩾30 mmHg, ranging between 30 and 83.6 mmHg. The meta-analysis (four studies) found toe systolic blood pressure 0.2, with one study reporting a higher value of 0.8. Main conclusions: Successful post-amputation healing outcomes were reported at mean toe systolic blood pressure ⩾30 mmHg, and the results varied considerably between the studies. Further research should identify whether variables, including amputation level, method of wound closure and length of post-operative follow-up periods, affect the values of toe systolic blood pressure and toe-brachial pressure index observed in this review

A Model for Patchy Reconnection in Three Dimensions

We show, theoretically and via MHD simulations, how a short burst of reconnection localized in three dimensions on a one-dimensional current sheet creates a pair of reconnected flux tubes. We focus on the post-reconnection evolution of these flux tubes, studying their velocities and shapes. We find that slow-mode shocks propagate along these reconnected flux tubes, releasing magnetic energy as in steady-state Petschek reconnection. The geometry of these three-dimensional shocks, however, differs dramatically from the classical two-dimensional geometry. They propagate along the flux tube legs in four isolated fronts, whereas in the two-dimensional Petschek model, they form a continuous, stationary pair of V-shaped fronts. We find that the cross sections of these reconnected flux tubes appear as teardrop shaped bundles of flux propagating away from the reconnection site. Based on this, we argue that the descending coronal voids seen by Yohkoh SXT, LASCO, and TRACE are reconnected flux tubes descending from a flare site in the high corona, for example after a coronal mass ejection. In this model, these flux tubes would then settle into equilibrium in the low corona, forming an arcade of post-flare coronal loops.Comment: 27 pages plus 16 figure

Structural basis for the modulation of MRP2 activity by phosphorylation and drugs.

Multidrug resistance-associated protein 2 (MRP2/ABCC2) is a polyspecific efflux transporter of organic anions expressed in hepatocyte canalicular membranes. MRP2 dysfunction, in Dubin-Johnson syndrome or by off-target inhibition, for example by the uricosuric drug probenecid, elevates circulating bilirubin glucuronide and is a cause of jaundice. Here, we determine the cryo-EM structure of rat Mrp2 (rMrp2) in an autoinhibited state and in complex with probenecid. The autoinhibited state exhibits an unusual conformation for this class of transporter in which the regulatory domain is folded within the transmembrane domain cavity. In vitro phosphorylation, mass spectrometry and transport assays show that phosphorylation of the regulatory domain relieves this autoinhibition and enhances rMrp2 transport activity. The in vitro data is confirmed in human hepatocyte-like cells, in which inhibition of endogenous kinases also reduces human MRP2 transport activity. The drug-bound state reveals two probenecid binding sites that suggest a dynamic interplay with autoinhibition. Mapping of the Dubin-Johnson mutations onto the rodent structure indicates that many may interfere with the transition between conformational states