Pedagogical conditions of primary drug abuse prevention among students of a higher education institution

The relevance of the researched problem is caused by the fact that being one of the least adapted and socially unprotected groups, young people bear the impress of general social uncertainty, lack of confidence and uneasiness, as a result of it, drug addiction problems among young people are pushed into the forefront among social-pedagogical and psychological-pedagogical problems. The purpose of the presented article consists in theoretical reasons, development experimental and research check of a complex of the pedagogical conditions providing efficiency of primary prevention of drug addiction among students of a higher education institution. The leading method to a research of this problem is the modeling method that enables to consider this problem as a purposeful and organized process of creation of the pedagogical conditions necessary for effective primary prevention of drug addiction among students of a higher education institution. The complex of the pedagogical conditions providing efficiency of process of primary drug abuse prevention is presented in the article. It consists of the pedagogical analysis of the reasons of a drug abuse, detection of specifics of a drug abuse of youthful age, the choice and use of the methods and agents of primary prophylaxis of a youth drug abuse, development of a special course for training of specialists which are carrying out activities for prophylaxis of the drug habit at educational organizations. The complex of pedagogical conditions is focused on the process organization of drug abuse prevention among students and focused on development of methodical ensuring process of training of the teachers who are carrying out activities for drug abuse prevention in educational organizations. The materials of article can be useful to teachers of higher education institutions and colleges participating in the organization and carrying out preventive measures of a drug addiction, and also to the listeners, graduates of military academies, and practical staffof Department of Internal Affairs of the Russian Federation who are interested in drug addiction problems. © Authors

High Resolution Infrared Spectroscopy in Support of Ozone Atmospheric Monitoring and Validation of the Potential Energy Function

The first part of this review is a brief reminder of general information concerning atmospheric ozone, particularly related to its formation, destruction, observations of its decrease in the stratosphere, and its increase in the troposphere as a result of anthropogenic actions and solutions. A few words are said about the abandonment of the Airbus project Alliance, which was expected to be the substitute of the supersonic Concorde. This project is over due to the theoretical evaluation of the impact of a fleet in the stratosphere and has been replaced by the A380, which is now operating. The largest part is devoted to calculations and observations of the transitions in the infrared range and their applications for the atmosphere based both on effective models (Hamiltonian, symmetry rules, and dipole moments) and ab initio calculations. The complementarities of the two approaches are clearly demonstrated, particularly for the creation of an exhaustive line list consisting of more than 300,000 lines reaching experimental accuracies (from 0.00004 to 0.001 cm−1) for positions and a sub percent for the intensities in the 10 microns region. This contributes to definitively resolving the issue of the observed discrepancies between line intensity data in different spectral regions: between the infrared and ultraviolet ranges, on the one hand, and between 10 and 5 microns on the other hand. The following section is devoted to the application of recent work to improve the knowledge about the behavior of potential function at high energies. A controversial issue related to the shape of the potential function in the transition state range near the dissociation is discussed. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Funding: The activities of S.M. and E.S. were supported by the Ministry of Science and Higher Education of the Russian Federation (V.E. Zuev Institute of Atmospheric Optics SB RAS); the work of S.M. was also supported by Ural Federal University

IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES

Many pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low pH at the site of infection or in phagolysosome, as well as in anaerobic conditions, and also leads to deficiency of arginine. Metabolism of arginine plays an important role in regulating the functions of immune system cells in mammals. Arginine is a substrate of enzymes NOS and arginase. Arginine depletion, potentially contributs to immunosuppression. The review analyzed the literature data on the effect of streptococcal arginine deiminase on the metabolism of arginine eukaryotic cells, and discusses immunosuppressive action of the enzyme

2-(4-Chloro­benzo­yl)-1-(diamino­methyl­ene)hydrazinium chloride monohydrate

In the cation of the title compound, C8H10ClN4O+·Cl−·H2O, the guanidinium group is planar (maximum deviation = 0.0001 Å) and nearly perpendicular to carboxamide group, making a dihedral angle of 87.0 (3)°. The N atoms of the guanidine fragment have a planar trigonal configuration and the N atom of the carboxamide group adopts a pyramidal configuration. In the crystal structure, inter­molecular N—H⋯O, N—H⋯Cl and O—H⋯Cl hydrogen bonds link the cations, anions and water mol­ecules into layers parallel to the bc plane

Efficacy of genetically engineered biological agents in the treatment of uveitis associated with rheumatic diseases in children

The efficiency of incorporating genetically engineered biological agents (GEBAs) into a combination treatment regimen for rheumatic diseases (RD) (juvenile idiopathic arthritis, Behcet's disease) in relation to associated uveitis of varying severity was studied in 92 children aged 2 to 17 years. The follow-up lasted 1.5 to 49 months. Twenty-three patients took consecutively 2 to 5 GEBAs. When infliximab was used, remission of uveitis occurred in 21% of 38 children and the disease activity and/or recurrence rates reduced in an additional 21%. These were in 45 and 38.6% of 44 patients on adalimumab (ADA) and in 27.8 and 27.8% of 18 patients on abatacept, respectively. There was an association of the efficiency of therapy with the severity of uveitis at the start of treatment. The use of ADA induced a steady remission of panuveitis resistant to therapy with glucocorticoids and cyclosporine in both patients with Behcet's disease. One of 4 rituximab-treated patients achieved a steady remission. Tocilizumab therapy caused an exacerbation of uveitis in 1 patient. The postoperative period showed no inflammatory complications in most cases (37 operations, 26 eyes, 20 patients). No local adverse reactions were seen; systemic reactions occurred in 14% of the patients, this caused GEBAs to be discontinued in 7%. There is evidence for a need for further investigations into the efficacy of GEBAs in RD-associated uveitis in children in order to define success criteria, differentiated indications, and therapy regimens

Methodology for the development of spatial thinking in young climbers 7-10 years old

Рукопись поступила в редакцию: 19.02.2023. Принята к публикации: 13.03.2023.Received: 19.02.2023. Accepted: 13.03.2023.В статье обосновывается необходимость развития пространственного мышления юных спортсменов-скалолазов в возрасте 7-10 лет. Цель исследования заключалась в развития пространственного мышления юных скалолазов. В исследование принимали юные скалолазы 7-10 лет, которые были включены в контрольную и экспериментальную группу. В контрольной группе использовалась авторская методика развития пространственного мышления юных скалолазов. Результаты исследования доказывают повышение уровня развития пространственного мышления у юных скалолазов в экспериментальной группе. Исследование доказывает необходимость внедрения новых методик и средств по развитию пространственного мышления юных скалолазов и изучению взаимосвязи развития пространственного мышления и других физических качеств.The article substantiates the need for the development of spatial thinking of young athletes-climbers aged 7-10 years. The purpose of the study was to develop the spatial thinking of young climbers. The study involved young climbers 7-10 years old, who were included in the control and experimental groups. In the control group, the author’s methodology for the development of spatial thinking of young climbers was used. The results of the study prove an increase in the level of spatial thinking development among young climbers in the experimental group. The study proves the need for the introduction of new techniques and tools for the development of spatial thinking of young climbers and the study of the relationship between the development of spatial thinking and other physical qualities

Influence of streptococcal arginine deiminase on the leukocyte infiltration in murine air pouch model

Numerous pathogens express arginine deiminase, an enzyme that catalyzes the hydrolysis of L-arginine in a chain of biochemical reactions aimed at the synthesis of ATP in bacterial cells. L-arginine is a semi-essential, proteinogenic amino acid that plays an important role in regulating the functions of the immune system cells in mammals. Depletion of L-arginine may cause a weakening of the immune reaction. In order to improve the conditions of dissemination, many pathogens use a strategy of L-arginine depletion in the microenvironment of host cells. Bacterial arginine deiminase can be a pathogenicity factor aimed for dysregulating the processes of inflammation and immune response. In general, the effect of arginine deiminase on immune cells may result into disturbed production of regulatory proinflammatory molecules, such as NO, and related substances, inhibition of activation, migration and differentiation of individual leukocyte subsets. The aim of this study was to investigate the effect of arginine deiminase on the formation of inflammatory infiltrate in murine air pouch model of streptococcal infection. Materials and methods: The study was performed using S. pyogenes M49-16 expressing arginine deiminase and its isogenic mutant S. pyogenes M49-16delArcA with inactivated arginine deiminase gene. The flow cytometry analysis of the inflammatory infiltrate leukocytes subpopulation in mice infected with the original strain of S. pyogenes M49-16 and its isogenic mutant S. pyogenes M49-16delArcA at different periods of infection was performed. It was shown that the inflammation reached its peak 6 hours after streptococcal inoculation, being more pronounced in mice infected with the mutant strain. Тhis finding was affirmed by a simultaneous and more pronounced increase in the absolute numbers of all leukocyte subsets in the focus of inflammation in this group of mice when compared to mice infected with original bacterial strain. Despite the decrease in the absolute number of all leukocyte types in the inflammatory infiltrate in both groups of mice for 24 hours, this trend was more pronounced in the group of mice infected with mutant microbial strain. Comparison of the inflammatory infiltrates developing in mice infected with original versus mutant strains showed that arginine deiminase may be a pathogenicity factor leading to dysregulation of protective immune response, due to impaired migration of white blood cells to the site of infection

GEOCHRONOLOGY OF THE CHADOBETS ALKALINE ULTRAMAFIC CARBONATITE COMPLEX (SIBERIAN CRATON): NEW U-Pb AND Ar-Ar DATA

The Chadobets alkaline ultramafic carbonatite complex is located on the Siberian craton within the southern boundary of the Permian-Triassic plume activity. The dating of xenogenic zircons from the weathering crust of carbonatites of the Chuktukon complex yielded four clusters with ages of 1870–1820, 495–385, 290–210 and 215–162 Ma. The first two clusters correspond to the dates of activity of Paleoproterozoic granitoid magmatism and Paleozoic alkaline-mafic tectono-magmatic activity, widely occurred in the Siberian craton and its southern framing. The age of crystallization of alkaline rocks of the Chadobets complex falls within the interval of 255–240 Ma. Ar-Ar dating of damtjernite and carbonatite minerals of the Chuktukon complex falls within the intervals of 250.5±3.7 and 247.1±5.7 Ma, respectively. The crystallization ages of the mela-aillikites and damtjernites of the Terina complex, according to the Ar-Ar dating, correspond to the intervals of 257.4±3.9, 241.1±3.7, and 240±3.6 Ma. The age interval of 215–162 Ma based on zircons from the carbonatite weathering crust of the Chuktukon complex reflects the geochronology of superimposed processes and indicates the different stages of alteration of igneous rocks of the Chadobets complex. The data obtained on the age of crystallization of alkaline rocks of the Chadobets complex are consistent with the age interval of Siberian plume activity within a large igneous province (LIP)

From Euclidean Geometry to Knots and Nets

This document is the Accepted Manuscript of an article accepted for publication in Synthese. Under embargo until 19 September 2018. The final publication is available at Springer via https://doi.org/10.1007/s11229-017-1558-x.This paper assumes the success of arguments against the view that informal mathematical proofs secure rational conviction in virtue of their relations with corresponding formal derivations. This assumption entails a need for an alternative account of the logic of informal mathematical proofs. Following examination of case studies by Manders, De Toffoli and Giardino, Leitgeb, Feferman and others, this paper proposes a framework for analysing those informal proofs that appeal to the perception or modification of diagrams or to the inspection or imaginative manipulation of mental models of mathematical phenomena. Proofs relying on diagrams can be rigorous if (a) it is easy to draw a diagram that shares or otherwise indicates the structure of the mathematical object, (b) the information thus displayed is not metrical and (c) it is possible to put the inferences into systematic mathematical relation with other mathematical inferential practices. Proofs that appeal to mental models can be rigorous if the mental models can be externalised as diagrammatic practice that satisfies these three conditions.Peer reviewe