The Effect of Personal Health on the Formation of Human Capital: a Metasystem Approach

In article the problem of influence of the personality's health on formation of the human capital is considered. Authors have conducted theoretical researches of the existing knowledge of the human capital and justifications of influence of the personality's health on its formation are given. On the basis of the carried-out analysis it is established that now the personality's health is a significant factor of efficiency of any kind of activity and important quality of the personality, therefore, it can be considered as a factor of formation of the human capital. According to it need of determination of criteria, the indicators of health of the personality influencing formation and development of the human capital was designated

The effect of hydrogen on strain hardening and fracture mechanism of high-nitrogen austenitic steel

High-nitrogen austenitic steels are perspective materials for an electron-beam welding and for producing of wear-resistant coatings, which can be used for application in aggressive atmospheres. The tensile behavior and fracture mechanism of high-nitrogen austenitic steel Fe-20Cr-22Mn-1.5V-0.2C-0.6N (in wt.%) after electrochemical hydrogen charging for 2, 10 and 40 hours have been investigated. Hydrogenation of steel provides a loss of yield strength, uniform elongation and tensile strength. The degradation of tensile properties becomes stronger with increase in charging duration - it occurs more intensive in specimens hydrogenated for 40 hours as compared to ones charged for 2-10 hours. Fracture analysis reveals a hydrogen-induced formation of brittle surface layers up to 6 [mu]m thick after 40 hours of saturation. Hydrogenation changes fracture mode of steel from mixed intergranular-transgranular to mainly transgranular one

ROLE OF TARGETED THERAPY IN THE COMBINATION TREATMENT OF PATIENTS WITH KIDNEY CANCER AND METASTATIC BRAIN INVOLVEMENT

In patients with kidney cancer (KC), the rate of metastatic brain involvement is 2-11%, is steadily growing, and is one of the important reasons for treatment failures in these patients. Surgery and radiotherapy, including radiosurgery, must be considered as optimal treatments for patients with KC and brain metastases. Systemic drug therapy has recently played a more and more increasing role in the treatment of patients with a progressive brain tumor process. At the same time, there are no exact pharmacokinetic data on drugs registered for the treatment of disseminated KC in respect to their concentration in the human central nervous when they are used in therapeutic doses. On the basis of the data of the literature review and the results of the authors’ studies, it may be concluded that while none of the target agents has still shown any significant advantage over others in treating KC patients with brain metastases. All the drugs have demonstrated their ability to achieve a clinical and X-ray verified objective effect (as stabilizations in most cases) in treating brain metastases. The most data are available on the therapeutic efficacy of sunitinib and sorafenib. In case of progressive brain tumor process, drug treatment should be individually discussed in each situation in accordance with standard approaches to treating patients with disseminated KC

The Influence of Ion-Plasma Treatment on the Strength Characteristics of Austenitic Stainless Steel with Different Grain Sizes

In given work, the tensile properties and nanohardness of fine-grained (3–6 μm) and coarse-grained (55 μm) austenitic stainless steel specimens subjected to ion-plasma treatment in a mixture of gases N2+C2H2+Ar at a temperature of 540 °C for 12 hours were experimentally investigated.В работе исследованы механические свойства при растяжении и нанотвердость мелкозернистых (3–6 мкм) и крупнозернистых (55 мкм) образцов аустенитной нержавеющей стали, подвергнутой ионно-плазменной обработке в смеси N2 + C2H2 + Ar при температуре 540 °C в течение 12 ч.Работа выполнена при финансовой поддержке стипендии Президента РФ (СП-14.2019.1)