Socio-psycological aspects of stydying sharnirnay hinged pupet ( to the question of types of toys)

The material is devoted to the problems and type of games model of contemporary culture. We produce the variant of dolls types, division on the base realistic images. The popular bolt joined realistic doll isn’t the example of order games model.Статья посвящена специфике игровых моделей в современной культуре, предлагается вариант типологии игрушки, где разделение проводится по границе подвижности и степени условности. Шарнирная реалистичная кукла рассматривается как проявление нарушения основополагающих законов игры и отсутствия необходимых культурных цензов в современном социуме

Analytically solvable model of a driven system with quenched dichotomous disorder

We perform a time-dependent study of the driven dynamics of overdamped particles which are placed in a one-dimensional, piecewise linear random potential. This set-up of spatially quenched disorder then exerts a dichotomous varying random force on the particles. We derive the path integral representation of the resulting probability density function for the position of the particles and transform this quantity of interest into the form of a Fourier integral. In doing so, the evolution of the probability density can be investigated analytically for finite times. It is demonstrated that the probability density contains both a $\delta$-singular contribution and a regular part. While the former part plays a dominant role at short times, the latter rules the behavior at large evolution times. The slow approach of the probability density to a limiting Gaussian form as time tends to infinity is elucidated in detail.Comment: 18 pages, 5 figure

On a possibility of inelasticity partial coefficient K sub gamma determination in pi C and pi Pb interactions at 10 to the 14th power eV (experiment PAMIR 1)

The investigation of hadron-nuclear interactions in Pamir experiment is carried out by means of X-ray emulsion chambers of two types: carbon (C) and lead (Pb). While comparing the results from the chambers of both types it was found a discrepancy in n sub h and E sub h(1)R values. The observed discrepancy in C and Pb chambers is connected with the difference in values of effective coefficients of energy transfer to the soft component K sub eff for C and Pb chambers

Beta-blockers and chronic kidney disease: a literature review

Chronic kidney disease (CKD) and cardiovascular diseases are widespread throughout the world and are closely related to each other. Sympathetic hyperactivity, characteristic of CKD, increases cardiovascular risk and accelerates the progression of kidney disease by activating beta-adrenergic receptors. Beta-blockers play an important role in preventing the negative effects of in creased activity of the sympathetic nervous system on the cardiovascular system and kidneys, can slow the progression of renal disease, and have proven effective in reducing overall and cardiovascular mortality and treatment of coronary heart disease, heart failure, arterial hypertension, and arrhythmias in patients with CKD. Despite this, beta-blockers are still underused in patients with CKD, especially in its later stages, including ESRD. Although there are currently no clear recommendations for the choice of any specific beta blocker in CKD, factors such as the CKD stage, presence of diabetes mellitus or reduced insulin sensitivity, and pharmacodynamics (cardioselectivity, α1-blocking- and vasodilating properties) and pharmacokinetic properties (metabolism, routes of elimination from the body, degree of binding to plasma proteins and dualizability) should be considered. At present, along with ACE inhibitors, AT1-receptor antagonists, and SGLT2 inhibitors, beta-blockers remain indispensable drugs for treating cardiovascular diseases with proven positive effects on the progression of kidney failure in patients with CKD. Their broader use in this population is expected to further reduce cardiovascular mortality and delay the initiation of renal replacement therapy

PReS-FINAL-2041: Macrophage activation syndrome in the children with systemic juvenile idiopathic arthritis during the course of tocilizumab

Background Trauma exposure and posttraumatic stress disorder (PTSD) are common among individuals with a mental disorder, but symptoms often go undetected and untreated. Methods The aim of this study was to determine the prevalence of PTSD among a large sample of adults with psychiatric diagnoses and to establish factors associated with symptoms going undetected. Participants were 1,946 adults recruited by the National Centre for Mental Health. Structured interviews and validated self-report questionnaires were used to ascertain clinical and demographic information for analysis. Results The prevalence of participants screening positive for PTSD that had not been detected by clinical services was 13.9% [12.4–15.5%, 95% confidence interval]). Factors associated with undetected PTSD were female gender, younger age of first contact with psychiatric services, and lower household income. Especially, poor rates of detection were observed after traumatic events, such as child abuse and sexual assault. Conclusions Our findings demonstrate the need for routine assessment of trauma histories and symptoms of PTSD among individuals with anymental disorder

Nutritional habits of athletes in speed-and-strength sports

Speed-and-strength sports differ from other sports because of its short time and very intense physical activity. ^e review provides a literature analysis of the effect of nutrients on the metabolic processes that occur during the occupation of these sports. During the training of athletes generally anaerobic mechanisms of muscular work dominate, so the nutrition of athletes focuses on the consumption of foods with high protein content and essential amino acids. ^e article describes general principles of diet constructing for athletes that should correspond to the basics of optimal nutrition, depend on the period of sport activity (training, competition, recovery), the duration and intensity of physical exertion, etc. Based on the results of recent studies published by domestic and foreign authors, the substantiation of the energy value and the chemical composition of the diet (the content of proteins, fats, carbohydrates, vitamins, macro- and microelements), as well as the formation of diets and drinking regime for highly skilled athletes involved in speed-and-strength sports is given

New device for air disinfection with a shielded UV radiation and ozone

Received: February 1st, 2021 ; Accepted: May 2nd, 2021 ; Published: May 7th, 2021 ; Correspondence: [email protected] air disinfection has become particularly relevant recently because of the Covid-19 pandemics. A shielded device for air and surface disinfection with UV radiation and ozone has been developed. It contains 28 low intensity (11 W) UV lamps (254 nm) in a specially designed three-dimensional grid to provide a large flow cross-sectional area and long path for the air particles to be irradiated. The device can be used in medical institutions, veterinary clinics, manufacturing plants, public premises, poultry, and livestock farms. It does not generate air-ions and ozone concentrations do not exceed the allowed 8-hour average values. The large number of UV lamps and powerful fans ensure air disinfection in large rooms in a relatively short time (400 m3 h -1 ). Simultaneously, the floor surface under the appliance is disinfected. Disinfection efficiency tests demonstrated 99.9999% reduction for Escherichia coli, Staphylococcus aureus and Pseudomonas phage Φ6 aerosols within a single transfer through the system (10 seconds of treatment). The housing of the device protects from direct UV radiation; therefore, people can be in the room during the operation of the device

SERS investigation of neocuproine adsorption on silver: Influence of electrode potential on methyl groups

© 2017 John Wiley & Sons, Ltd. Study of molecules adsorption on charged surfaces is important for biologically relevant substances where the potential at the interface such as living cell membrane is a significant parameter in the processes of their transportation or transmembrane penetration. In this work, a hybrid optical/electrochemical surface-enhanced Raman scattering (SERS) technique was applied to get new insight into the adsorption state and conformational equilibrium of neocuproine, which serves as a nucleic acid biosensor in clinical diagnostics and has biological activity towards several types of carcinoma. The density functional theory calculations performed for several rotational conformations and their anion radicals were used to determine the geometrical and energetic characteristics, to evaluate the rotational barrier, to obtain the vibrational assignment, and to consider the metal-adsorbate charge transfer. The dependence of SERS spectra on surface potential is ascribed to a change of the rotational dynamics of methyl groups from hindered to almost free at potentials ≤-200 mV. It is demonstrated for the first time that SERS spectroscopy is capable to recognize the surface species, which differ in the methyl group internal rotation