Checkpoint Inhibitors in Nonsmall Cell Lung Cancer

Lung cancer remains the leading cause of cancer‐related deaths worldwide. The majority of NSCLC patients present with advanced stage disease. Lung cancer was once thought of as a low antigenicity cancer unlikely to benefit from immunotherapy, but has recently been found to have a high level of antigenicity. Moreover, a large body of research now exists to support both the safety and efficacy of immunotherapy in advanced stage NSCLC. The checkpoint inhibitors nivolumab, pembrolizumab, and atezolizumab are now approved by the U.S. Federal Drug Administration for second‐line treatment in advanced stage NSCLC. In addition to being efficacious, checkpoint inhibitors have a superior safety profile compared to previous standard of care, chemotherapy. Further trials are needed to investigate the checkpoint inhibitors’ role in combination treatment, first‐line treatment, and early stage disease

Completeness of birth registration in Brazil: an overview of methods and data sources

We provide an analysis of the main sources of data used to estimate fertility schedules in developing countries, giving special attention to Brazil. In addition to the brief history of various data sources, we present several indirect demographic methods, commonly used to estimate fertility and assess the quality of data. From the methods used, the Synthetic Relational Gompertz model gives the most robust estimates of fertility, independent of the data source considered. We conclude that different demographic data sources and methods generate differing estimates of fertility and that the country should invest in quality of birth statistics

Children’s Strategies for Displaying Anger and Sadness: What Works With Whom?

This study examined the influence of expressive strategies (i.e., verbal, facial, crying, sulking, and aggressive), emotion type (i.e., anger, sadness), social context (i.e., mother, father, best friend), age (i.e., 7, 10 years), and gender on 144 children’s expectancies regarding interpersonal responses to their emotional expression. Participants included 72 boys and 72 girls, with an average age of 8 years and 10 months. Results indicate that children expect others to respond more positively to certain expressive strategies (e.g., verbal, facial) as compared to others (e.g., aggression) and that these expectancies vary as a function of the type of emotion experienced, the social context, age, and gender. Consistent with the functionalist approach to emotion, findings suggest that, through social interaction, children learn culturally appropriate strategies for emotional expression that facilitate their ability to elicit a desired response from social partners

Characterisation of contact twinning for cerussite, PbCO3, by single-crystal NMR spectroscopy

<jats:title>Abstract</jats:title><jats:p>Cerussite, <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\hbox {PbCO}_3$$</jats:tex-math><mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"> <mml:msub> <mml:mtext>PbCO</mml:mtext> <mml:mn>3</mml:mn> </mml:msub> </mml:math></jats:alternatives></jats:inline-formula>, like all members of the aragonite group, shows a tendency to form twins, due to high pseudo-symmetry within the crystal structure. We here demonstrate that the twin law of a cerussite contact twin may be established using only <jats:inline-formula><jats:alternatives><jats:tex-math>$$^{207}$$</jats:tex-math><mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"> <mml:msup> <mml:mrow /> <mml:mn>207</mml:mn> </mml:msup> </mml:math></jats:alternatives></jats:inline-formula>Pb-NMR spectroscopy. This is achieved by a global fit of several sets of orientation-dependent spectra acquired from the twin specimen, allowing to determine the relative orientation of the twin domains. Also, the full <jats:inline-formula><jats:alternatives><jats:tex-math>$$^{207}$$</jats:tex-math><mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"> <mml:msup> <mml:mrow /> <mml:mn>207</mml:mn> </mml:msup> </mml:math></jats:alternatives></jats:inline-formula>Pb chemical shift tensor in cerussite at room temperature is determined from these data, with the eigenvalues being <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\delta _{11} = (-2315\\pm 1)$$</jats:tex-math><mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"> <mml:mrow> <mml:msub> <mml:mi>δ</mml:mi> <mml:mn>11</mml:mn> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mo>(</mml:mo> <mml:mo>-</mml:mo> <mml:mn>2315</mml:mn> <mml:mo>±</mml:mo> <mml:mn>1</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math></jats:alternatives></jats:inline-formula> ppm, <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\delta _{22} = (-2492 \\pm 3)$$</jats:tex-math><mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"> <mml:mrow> <mml:msub> <mml:mi>δ</mml:mi> <mml:mn>22</mml:mn> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mo>(</mml:mo> <mml:mo>-</mml:mo> <mml:mn>2492</mml:mn> <mml:mo>±</mml:mo> <mml:mn>3</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math></jats:alternatives></jats:inline-formula> ppm, and <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\delta _{33} = (-3071 \\pm 3)$$</jats:tex-math><mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"> <mml:mrow> <mml:msub> <mml:mi>δ</mml:mi> <mml:mn>33</mml:mn> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mo>(</mml:mo> <mml:mo>-</mml:mo> <mml:mn>3071</mml:mn> <mml:mo>±</mml:mo> <mml:mn>3</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math></jats:alternatives></jats:inline-formula> ppm.</jats:p&gt

Local Electronic Structure in AlN Studied by Single-Crystal ²⁷Al and ¹⁴N NMR and DFT Calculations

Both the chemical shift and quadrupole coupling tensors for 14 N and 27 Al in the wurtzite structure of aluminum nitride have been determined to high precision by single-crystal NMR spectroscopy. A homoepitaxially grown AlN single crystal with known morphology was used, which allowed for optical alignment of the crystal on the goniometer axis. From the analysis of the rotation patterns of 14 N ( I=1 ) and 27 Al ( I=5/2 ), the quadrupolar coupling constants were determined to χ(14N)=(8.19±0.02) kHz, and χ(27Al)=(1.914±0.001) MHz. The chemical shift parameters obtained from the data fit were δiso=−(292.6±0.6) ppm and δΔ=−(1.9±1.1) ppm for 14 N, and (after correcting for the second-order quadrupolar shift) δiso=(113.6±0.3) ppm and δΔ=(12.7±0.6) ppm for 27 Al. DFT calculations of the NMR parameters for non-optimized crystal geometries of AlN generally did not match the experimental values, whereas optimized geometries came close for 27 Al with χ¯¯calc=(1.791±0.003) MHz, but not for 14 N with χ¯¯calc=−(19.5±3.3) kHz