An uncommon case of an adult with del(5)(q) in acute lymphoblastic leukemia

Del(5)(q) is a common chromosomal abnormality with favourable prognosis in Myelodysplastic Syndrome (MDS) and Acute myeloid leukemia (AML). However, del(5)(q) is also seen rarely in Acute lymphoblastic leukemia (ALL) and its significance remains poorly understood. We present here, a case report of diagnosis of an adult 75 year old patient of ALL with a cytogenetic abnormality of del(5)(q32). His clinical features, morphology and immunophenotyping findings were suggestive of T-ALL. Relevant literature has been reviewed and discussed

Nanowire Morphology of Mono- and Bidoped α‑MnO₂ Catalysts for Remarkable Enhancement in Soot Oxidation

In the present work, nanowire morphologies of α-MnO₂, cobalt monodoped α-MnO₂, Cu and Co bidoped α-MnO₂, and Ni and Co bidoped α-MnO₂ samples were prepared by a facile hydrothermal synthesis. The structural, morphological, surface, and redox properties of all the as-prepared samples were investigated by various characterization techniques, namely, scanning electron microscopy (SEM), transmission and high resolution electron microscopy (TEM and HR-TEM), powder X-ray diffraction (XRD), N₂ sorption surface area measurements, X-ray photoelectron spectroscopy (XPS), hydrogen-temperature-programmed reduction (H₂-TPR), and oxygen-temperature-programmed desorption (O₂-TPD). The soot oxidation performance was found to be significantly improved via metal mono- and bidoping. In particular, Cu and Co bidoped α-MnO₂ nanowires showed a remarkable improvement in soot oxidation performance, with its <i>T</i>₅₀ (50% soot conversion) values of 279 and 431 °C under tight and loose contact conditions, respectively. The soot combustion activation energy for the Cu and Co bidoped MnO₂ nanowires is 121 kJ/mol. The increased oxygen vacancies, greater number of active sites, facile redox behavior, and strong synergistic interaction were the key factors for the excellent catalytic activity. The longevity of Cu and Co bidoped α-MnO₂ nanowires was analyzed, and it was found that the Cu/Co bidoped α-MnO₂ nanowires were highly stable after five successive cycles and showed an insignificant decrease in soot oxidation activity. Furthermore, the HR-TEM analysis of a spent catalyst after five cycles indicated that the (310) crystal plane of α-MnO₂ interacts with the soot particles; therefore, we can assume that more-reactive exposed surfaces positively affect the reaction of soot oxidation. Thus, the Cu and Co bidoped α-MnO₂ nanowires provide promise as a highly effective alternative to precious metal based automotive catalysts

Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures.

The genus Flavivirus contains many mosquito-borne human pathogens of global epidemiological importance such as dengue virus, West Nile virus, and Zika virus, which has recently emerged at epidemic levels. Infections with these viruses result in divergent clinical outcomes ranging from asymptomatic to fatal. Myriad factors influence infection severity including exposure, immune status and pathogen/host genetics. Furthermore, pre-existing infection may skew immune pathways or divert immune resources. We profiled immune cells from dengue virus-infected individuals by multiparameter mass cytometry (CyTOF) to define functional status. Elevations in IFNβ were noted in acute patients across the majority of cell types and were statistically elevated in 31 of 36 cell subsets. We quantified response to in vitro (re)infection with dengue or Zika viruses and detected a striking pattern of upregulation of responses to Zika infection by innate cell types which was not noted in response to dengue virus. Significance was discovered by statistical analysis as well as a neural network-based clustering approach which identified unusual cell subsets overlooked by conventional manual gating. Of public health importance, patient cells showed significant enrichment of innate cell responses to Zika virus indicating an intact and robust anti-Zika response despite the concurrent dengue infection