Sculpted Bedrock Forms along the Niagara Escarpment, Niagara Peninsula, Ontario

Assemblages of subglacial sculpted bedrock forms (p-forms; Dahl, 1965) are identified on resistant units of the Niagara Escarpment in the Niagara Peninsula, and on the Onondaga Escarpment. The scale of the features is much larger than previously recorded for bedrock glacial features in the Peninsula (Feenstra, 1981) and we suggest that there is a continuous spectrum of forms from small obstacle marks with dimensions of a few centimetres, through ridges and furrows measured in tens of metres, to promontories on the order of kilometres. Such assemblages comprise fluted surfaces with a consistent orientation between N40E and N45E, and which show very little variation within a site. Mapping the features has increased our awareness of their extent, and of the problems they pose for mechanisms proposed to explain them. The morphometry of the forms is similar to that described elsewhere, and the irregular edge of the Niagara Escarpment to oncoming flows is thought to be responsible for the prominent features described. The apparent removal of substantial bedrock blocks implies flow velocity well in excess of 3 m/s. Therefore the sculpting of the forms is attributed to fast flowing subglacial meltwater which may have had a discharge of the magnitude of 2.1 x 106 cumecs.On a identifié des ensembles de formes sous-glaciaires sculptées dans la roche en place (p-forms) dans des unités de roches résistantes de l'escarpement du Niagara et de l'escarpement d'Onondaga. L'échelle de ces formes est beaucoup plus grande que ce qu'on a déjà rapporté sur les formes glaciaires dans la roche en place de l'escarpement (Feenstra, 1981); nous croyons que ces formes existent dans toutes les tailles, à partir des simples marques de quelques centimètres en passant par des crêtes et des entailles décamétriques, jusqu'aux promontoires de l'ordre du kilomètre. De tels ensembles comprennent des surfaces cannelées dont l'orientation préférentielle se situe entre N40E et N45E et qui montre très peu de variation à l'intérieur d'un même site. La cartographie de ces formes a permis de se rendre compte de leur grande étendue et des difficultés de comprendre les mécanismes qui en sont à l'origine. La morphométrie des formes est semblable à ce que l'on a déjà décrit; on croit que la forme irrégulière du rebord qu'oppose l'escarpement du Niagara aux écoulements est responsable pour les formes remarquables décrites. L'enlèvement apparent de gros blocs de roche en place suppose des vitesses d'écoulement de plus de 3 m/s. Conséquemment, la sculpture des formes est attribuée à une eau de fusion sousglaciaire très rapide qui a pu avoir un débit de l'ordre de 2,1 x 10em3/s

The COVID-19 pandemic and primary care appointment availability by physician age and gender

Using data generated through simulated patient calls to a national random sample of primary care physicians between February and July 2020, we examine the effects of the first wave of COVID-19 on the availability of the U.S. primary care physician workforce for routine new patient appointments. As states enacted stay-at-home orders, physicians overall became less selective by insurance, and there was a 7 percentage-point increase in acceptance of patient insurance. Telemedicine appointment offers increased 10.2 percentage points from near zero. However, relative to younger counterparts, physicians older than the sample mean (53.1 years) became 18.1 percentage points less likely to offer appointments and decreased their estimated appointment duration by 7.1 min. Compared to male physicians, female physicians became 10 percentage points more likely to accept new patients. These insights into appointment offers during the first wave of COVID-19 may help policymakers seeking to ensure an adequate physician workforce during future crises

Developing a Raman spectroscopy-based tool to stratify patient response to pre-operative radiotherapy in rectal cancer

Rectal cancer patients frequently receive pre-operative radiotherapy (RT), prior to surgical resection. However, colorectal cancer is heterogeneous and the degree of tumour response to pre-operative RT is highly variable. There are currently no clinically approved methods of predicting response to RT, and a significant proportion of patients will show no clinical benefit, despite enduring the side-effects. We evaluated the use of Raman spectroscopy (RS), a non-destructive technique able to provide the unique chemical fingerprint of tissues, as a potential tool to stratify patient response to pre-operative RT. Raman measurements were obtained from the formalin-fixed, paraffin-embedded (FFPE) pre-treatment biopsy specimens of 20 rectal cancer patients who received pre-operative RT. A principal component analysis and linear discriminant analysis algorithm was able to classify patient response to pre-operative RT as good or poor, with an accuracy of 86.04 ± 0.14% (standard error). Patients with a good response to RT showed greater contributions from protein-associated peaks, whereas patients who responded poorly showed greater lipid contributions. These results demonstrate that RS is able to reliably classify tumour response to pre-operative RT from FFPE biopsies and highlights its potential to guide personalised cancer patient treatment

5-Aminolevulinic acid-mediated fluorescence diagnosis of colon cancer: A histopathological comparison of fluorescent and non-fluorescent tumours

Background: 5-Aminolevulinic acid (5-ALA) selectively accumulates in cancer cells and is metabolised in the mitochondria to the fluorophore protoporphyrin IX. The GLiSten trial evaluated 5-ALA as a fluorescent probe for intraoperative detection of colon cancer and lymph node metastases. Only 13 of 40 cases showed fluorescence, suggesting a fundamental difference between fluorescent and non-fluorescent cancers. The aim of this study was to investigate whether differences in fluorescence were due to tumour cellularity, in particular T cell infiltration, which may be of prognostic significance. Method: Primary tumour tissue was available from 30 patients. The density of tumour cells, vascularity and stromal compartment size were quantified using digitally scanned tissue sections stained with haematoxylin and eosin. A set of 300 random points was superimposed onto each tumour image. The structure indicated by each point was then categorised as tumour, stroma, vessel or other. The proportions of tumour and vessel points gave the tumour cell density and vessel density respectively. The relative size of the stromal compartment was given by the tumour to stroma ratio. A tissue section was also stained for the T cell marker CD3 by immunohistochemistry. Percentage staining was quantified in three high-density fields using the Nuance imaging system. Results: We were unable to detect any difference between fluorescent and non-fluorescent cancers in terms of tumour cell density (difference in means 3.7%; P = 0.452), vessel density (difference in means 0.17%; P = 0.684), tumour-stroma ratio (difference in mean ratios 0.12; P = 0.934), or T cell count (difference in means 0.92%; P = 0.726). Furthermore, comparisons of the distributions of each variable demonstrated substantial overlap between the fluorescent and non-fluorescent cohorts. Conclusion: The results suggest that tumour and microenvironment structure do not differ between cancers that fluoresce with 5-ALA and those that do not. We therefore propose that the cellular metabolism of 5-ALA is a more likely explanation for differential fluorescence

The gas turbulence in planetary nebulae: quantification and multi-D maps from long-slit, wide-spectral range echellogram

This methodological paper is part of a short series dedicated to the long-standing astronomical problem of de-projecting the bi-dimensional, apparent morphology of a three-dimensional distribution of gas. We focus on the quantification and spatial recovery of turbulent motions in planetary nebulae (and other classes of expanding nebulae) by means of long-slit echellograms over a wide spectral range. We introduce some basic theoretical notions, discuss the observational methodology, and develop an accurate procedure disentangling all broadening components of the velocity profile in all spatial positions of each spectral image. This allows us to extract random, non-thermal motions at unprecedented accuracy, and to map them in 1-, 2- and 3-dimensions. We present the solution to practical problems in the multi-dimensional turbulence-analysis of a testing-planetary nebula (NGC 7009), using the three-step procedure (spatio-kinematics, tomography, and 3-D rendering) developed at the Astronomical Observatory of Padua. In addition, we introduce an observational paradigm valid for all spectroscopic parameters in all classes of expanding nebulae. Unsteady, chaotic motions at a local scale constitute a fundamental (although elusive) kinematical parameter of each planetary nebula, providing deep insights on its different shaping agents and mechanisms, and on their mutual interaction. The detailed study of turbulence, its stratification within a target and (possible) systematic variation among different sub-classes of planetary nebulae deserve long-slit, multi-position angle, wide-spectral range echellograms containing emissions at low-, medium-, and high-ionization, to be analyzed pixel-to-pixel with a straightforward and versatile methodology, extracting all the physical information stored in each frame at best.Comment: 11 page, 10 figures, A&A in pres

Design and characterization of high optical quality InGaAs/GaAs/AlGaAs-based polariton microcavities

The presence of dislocations arising from strain relaxation strongly affects polaritons through their photonic component and ultimately limits experiments involving polariton propagation. In this work, we investigate the range of growth parameters to achieve high optical quality GaAs/AlxGa1−xAs-based microcavities containing strained InxGa1−xAs quantum wells and using differential interference contrast (Nomarski) microscopy deduce a design rule for homogeneous versus disordered structures. We illustrate the effect of disorder by contrasting observations of polariton condensates in relaxed and unrelaxed microcavities. In our optimized device, we generate a polariton condensate and deduce a lifetime for the interacting polariton fluid of 39 ± 2 ps