Elevated plasma CXCL12 alpha is associated with a poorer prognosis in pulmonary arterial hypertension.

Recent work in preclinical models suggests that signalling via the pro-angiogenic and proinflammatory cytokine, CXCL12 (SDF-1), plays an important pathogenic role in pulmonary hypertension (PH). The objective of this study was to establish whether circulating concentrations of CXCL12α were elevated in patients with PAH and related to mortalit

Information System Data Population In Gunung Panjang Samarinda Seberang

The development of technology today is getting Faster. With the sophistication of today's technology, we can facilitate the work to be done. We can find the information we need and we can expand the communication network using advanced technology. Currently, population data collection in the government system can be said to be ineffective. Population data collection with a manual system can cause inefficient processing of population data and administrative services will take a longer time. This study uses two methods of data collection, namely: interviews (interviews) and observation. The system development used in this research is the Waterfall model, which starts with the analysis, design, coding, testing, and maintenance stages. The Gunung Panjang Village Population Data Information System was created using several programming languages, Hypert Text Markup Language (HTML), Hypertext Preprocessor (PHP), and Cascading Style Sheet (CSS). and MySQL. It can be concluded that the results of this study are an Information System for Population Data Collection in Gunung Panjang Village which can be used for processing population data and as a means of delivering information on Gunung Panjang Village through the website

Antagonism of CXCR7 attenuates chronic hypoxia-induced pulmonary hypertension

Chemokines may directly participate in the pathogenesis of neonatal chronic hypoxia-induced pulmonary hypertension (PH). Although stromal-derived factor-1 (SDF-1) has been shown to be involved in PH, the role of its most recently discovered receptor, chemokine receptor type 7 (CXCR7), remains unclear. We sought to determine whether antagonism of the CXCR7 receptor would decrease pulmonary vascular remodeling in newborn mice exposed to chronic hypoxia by decreasing pulmonary vascular cell proliferation. Neonatal mice were exposed to hypoxia (fractional inspired oxygen concentration = 0.12) or room air (RA) for 2 wk. After 1 wk of exposure, mice received daily injections of placebo or a CXCR7 antagonist (CCX771) from postnatal day 7 (P7) to P14. Right ventricular systolic pressure (RVSP), the ratio of the weight of the right ventricle to left ventricle + septum (RV/LV + S), and pulmonary vascular cell proliferation and remodeling were determined at P14. As compared with mice exposed to RA, hypoxia placebo mice had a significant increase in the lung protein expression of CXCR7. Although hypoxic placebo-treated mice had a significant increase in RVSP, RV/LV+S, and pulmonary vascular cell proliferation and remodeling, the administration of CCX771 markedly decreased these changes. These results indicate that antagonism of CXCR7 may be a potent strategy to decrease PH and vascular remodeling