2,749 research outputs found
NuSTAR study of Hard X-Ray Morphology and Spectroscopy of PWN G21.5-0.9
We present NuSTAR high energy X-ray observations of the pulsar wind nebula
(PWN)/supernova remnant G21.5-0.9. We detect integrated emission from the
nebula up to ~40 keV, and resolve individual spatial features over a broad
X-ray band for the first time. The morphology seen by NuSTAR agrees well with
that seen by XMM-Newton and Chandra below 10 keV. At high energies NuSTAR
clearly detects non-thermal emission up to ~20 keV that extends along the
eastern and northern rim of the supernova shell. The broadband images clearly
demonstrate that X-ray emission from the North Spur and Eastern Limb results
predominantly from non-thermal processes. We detect a break in the spatially
integrated X-ray spectrum at ~9 keV that cannot be reproduced by current SED
models, implying either a more complex electron injection spectrum or an
additional process such as diffusion compared to what has been considered in
previous work. We use spatially resolved maps to derive an energy-dependent
cooling length scale, with . We find
this to be inconsistent with the model for the morphological evolution with
energy described by Kennel & Coroniti (1984). This value, along with the
observed steepening in power-law index between radio and X-ray, can be
quantitatively explained as an energy-loss spectral break in the simple scaling
model of Reynolds (2009), assuming particle advection dominates over diffusion.
This interpretation requires a substantial departure from spherical
magnetohydrodynamic (MHD), magnetic-flux-conserving outflow, most plausibly in
the form of turbulent magnetic-field amplification.Comment: 13 pages, 8 figures, 1 table, Accepted for publication in the
Astrophysical Journa
Exact symmetry breaking ground states for quantum spin chains
We introduce a family of spin-1/2 quantum chains, and show that their exact
ground states break the rotational and translational symmetries of the original
Hamiltonian. We also show how one can use projection to construct a spin-3/2
quantum chain with nearest neighbor interaction, whose exact ground states
break the rotational symmetry of the Hamiltonian. Correlation functions of both
models are determined in closed form. Although we confine ourselves to
examples, the method can easily be adapted to encompass more general models.Comment: 4 pages, RevTex. 4 figures, minor changes, new reference
Chemical characterization of a hypoglycemic extract from Cucurbita ficifolia bouche that induces liver glycogen accumulation in diabetic mice
Background: The aqueous extract of Cucurbita ficifolia (C. ficifolia) fruit has demonstrated hypoglycemic effect, which may be attributed to some components in the extract. However, the major secondary metabolites in this fruit have not yet been identified and little is known about its extra-pancreatic action, in particular, on liver carbohydrate metabolism. Therefore, in addition to the isolation and structural elucidation of the principal components in the aqueous extract of C. ficifolia, the aim of this study was to determine whether or not the hypoglycemic effect of the aqueous extract of Cucurbita ficifolia (C. ficifolia) fruit is due to accumulation of liver glycogen in diabetic mice.Materials and Methods: The aqueous extract from fruit of C. ficifolia was fractionated and its main secondary metabolites were purified and chemically characterized (NMR and GC-MS). Alloxan-induced diabetic mice received daily by gavage the aqueous extract (30 days). The liver glycogen content was quantified by spectroscopic method and by PAS stain; ALT and AST by spectrometric method; glycogen synthase, glycogen phosphorylase and GLUT2 by Western blot; the mRNA expression of GLUT2 and glucagon-receptor by RT-PCR; while serum insulin was quantified by ELISA method. A liver histological analysis was also performed by H&E stain.Results: Chemical fingerprint showed five majoritarian compounds in the aqueous extract of C. ficifolia: p-coumaric acid, p-hydroxybenzoic acid, salicin, stigmast-7,2,2-dien-3-ol and stigmast-7-en-3-ol. The histological analysis showed accumulation of liver glycogen. Also, increased glycogen synthase and decreased glycogen phosphorylase were observed. Interestingly, the histological architecture evidenced a liver-protective effect due the extract.Conclusion: Five compounds were identified in C. ficifolia aqueous extract. The hypoglycemic effect of this extract may be partially explained by liver glycogen accumulation. The bioactive compound responsible for the hypoglycemic effect of this extract will be elucidated in subsequent studies.Keywords: Cucurbita ficifolia, Cucurbitaceae, liver glycogen, hypoglycemic plants, p-coumaric acid, salicin, p-hydroxybenzoic aci
Recommended from our members
Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial.
BackgroundAdjuvant chemotherapy for resected early-stage non-small-cell lung cancer (NSCLC) provides a modest survival benefit. Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to platinum-based chemotherapy in advanced-stage non-squamous NSCLC. We aimed to evaluate the addition of bevacizumab to adjuvant chemotherapy in early-stage resected NSCLC.MethodsWe did an open-label, randomised, phase 3 trial of adult patients (aged ≥18 years) with an Eastern Cooperative Oncology Group performance status of 0 or 1 and who had completely resected stage IB (≥4 cm) to IIIA (defined by the American Joint Committee on Cancer 6th edition) NSCLC. We enrolled patients from across the US National Clinical Trials Network, including patients from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) affiliates in Europe and from the Canadian Cancer Trials Group, within 6-12 weeks of surgery. The chemotherapy regimen for each patient was selected before randomisation and administered intravenously; it consisted of four 21-day cycles of cisplatin (75 mg/m2 on day 1 in all regimens) in combination with investigator's choice of vinorelbine (30 mg/m2 on days 1 and 8), docetaxel (75 mg/m2 on day 1), gemcitabine (1200 mg/m2 on days 1 and 8), or pemetrexed (500 mg/m2 on day 1). Patients in the bevacizumab group received bevacizumab 15 mg/kg intravenously every 21 days starting with cycle 1 of chemotherapy and continuing for 1 year. We randomly allocated patients (1:1) to group A (chemotherapy alone) or group B (chemotherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by chemotherapy regimen, stage of disease, histology, and sex. No one was masked to treatment assignment, except the Data Safety and Monitoring Committee. The primary endpoint was overall survival, analysed by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00324805.FindingsBetween June 1, 2007, and Sept 20, 2013, 1501 patients were enrolled and randomly assigned to the two treatment groups: 749 to group A (chemotherapy alone) and 752 to group B (chemotherapy plus bevacizumab). 383 (26%) of 1458 patients (with complete staging information) had stage IB, 636 (44%) had stage II, and 439 (30%) had stage IIIA disease (stage of disease data were missing for 43 patients). Squamous cell histology was reported for 422 (28%) of 1501 patients. All four cisplatin-based chemotherapy regimens were used: 377 (25%) patients received vinorelbine, 343 (23%) received docetaxel, 283 (19%) received gemcitabine, and 497 (33%) received pemetrexed. At a median follow-up of 50·3 months (IQR 32·9-68·0), the estimated median overall survival in group A has not been reached, and in group B was 85·8 months (95% CI 74·9 to not reached); hazard ratio (group B vs group A) 0·99 (95% CI 0·82-1·19; p=0·90). Grade 3-5 toxicities of note (all attributions) that were reported more frequently in group B (the bevacizumab group) than in group A (chemotherapy alone) were overall worst grade (ie, all grade 3-5 toxicities; 496 [67%] of 738 in group A vs 610 [83%] of 735 in group B), hypertension (60 [8%] vs 219 [30%]), and neutropenia (241 [33%] vs 275 [37%]). The number of deaths on treatment did not differ between the groups (15 deaths in group A vs 19 in group B). Of these deaths, three in group A and ten in group B were considered at least possibly related to treatment.InterpretationAddition of bevacizumab to adjuvant chemotherapy did not improve overall survival for patients with surgically resected early-stage NSCLC. Bevacizumab does not have a role in this setting and should not be considered as an adjuvant therapy for patients with resected early-stage NSCLC.FundingNational Cancer Institute of the National Institutes of Health
Evolving wormhole geometries
We present here analytical solutions of General Relativity that describe
evolving wormholes with a non-constant redshift function. We show that the
matter that threads these wormholes is not necessarily exotic. Finally, we
investigate some issues concerning WEC violation and human traversability in
these time-dependent geometries.Comment: 12 pages latex, 3 figures, to appear in Phys. Rev. D., Title
correcte
Delivery outcomes in women with congenital heart disease: results from the Cuban National Programme for pregnancy and heart disease
Abstract Objective To inform on delivery outcomes achieved in congenital heart disease (CHD) patients by the Cuban National Programme for pregnancy and heart disease. Methods Single-centre retrospective study on a prospectively collected cardiac pregnancy database at a tertiary referral hospital (January 2000–May 2017). Primary outcomes: pregnancy duration, outcome, maternal/fetal complications. Results Four hundred sixty-seven pregnancies in 462 recorded cases reached third trimester. Median age: 25 (21–29) years. Patients presented in NYHA class I (97%, n = 453) or II (3%, n = 14), 6% (n = 27) had arrhythmias, 1% (n = 4) had co-morbidities, 1% (n = 4) had impaired left ventricular function. There were 464 singleton pregnancies and 3 twin pregnancies. Of the singleton pregnancies, one resulted in stillbirth (0.2%). The rest were live births (n = 463), median weight 3200 (2900–3421) grams. Median pregnancy duration: 39.1 (38.6–40) weeks. Caesarean rate: 34% (n = 156). All twin pregnancies (n = 3) resulted in live births (n = 6) via caesarean section, of median weight 2710 (2458–2850) grams and median pregnancy duration 37 (36–38) weeks. Maternal cardiovascular complications (< 0.5%, n = 2), and obstetric complications (14%, n = 67) did not result in any mortality. Small-for-gestational-age was the commonest neonatal complication (10%, n = 48), with zero mortality. Three neonates (1%) had CHD. Post-delivery maternal NYHA functional status: class I in 84% (n = 393), class II in 16% (n = 73), and class III in one patient (< 0.5%). Conclusion In middle-income countries management of CHD pregnancies according to existing guidelines can achieve good maternal and fetal outcomes
Microlensing by natural wormholes: theory and simulations
We provide an in depth study of the theoretical peculiarities that arise in
effective negative mass lensing, both for the case of a point mass lens and
source, and for extended source situations. We describe novel observational
signatures arising in the case of a source lensed by a negative mass. We show
that a negative mass lens produces total or partial eclipse of the source in
the umbra region and also show that the usual Shapiro time delay is replaced
with an equivalent time gain. We describe these features both theoretically, as
well as through numerical simulations. We provide negative mass microlensing
simulations for various intensity profiles and discuss the differences between
them. The light curves for microlensing events are presented and contrasted
with those due to lensing produced by normal matter. Presence or absence of
these features in the observed microlensing events can shed light on the
existence of natural wormholes in the Universe.Comment: 16 pages, 24 postscript figures (3 coloured), revtex style, submitted
to Phys. Rev.
NuSTAR Hard X-ray Survey of the Galactic Center Region I: Hard X-ray Morphology and Spectroscopy of the Diffuse Emission
We present the first sub-arcminute images of the Galactic Center above 10
keV, obtained with NuSTAR. NuSTAR resolves the hard X-ray source IGR
J17456-2901 into non-thermal X-ray filaments, molecular clouds, point sources
and a previously unknown central component of hard X-ray emission (CHXE).
NuSTAR detects four non-thermal X-ray filaments, extending the detection of
their power-law spectra with - up to ~50 keV. A
morphological and spectral study of the filaments suggests that their origin
may be heterogeneous, where previous studies suggested a common origin in young
pulsar wind nebulae (PWNe). NuSTAR detects non-thermal X-ray continuum emission
spatially correlated with the 6.4 keV Fe K fluorescence line emission
associated with two Sgr A molecular clouds: MC1 and the Bridge. Broad-band
X-ray spectral analysis with a Monte-Carlo based X-ray reflection model
self-consistently determined their intrinsic column density (
cm), primary X-ray spectra (power-laws with ) and set a
lower limit of the X-ray luminosity of Sgr A* flare illuminating the Sgr A
clouds to erg s. Above ~20 keV, hard
X-ray emission in the central 10 pc region around Sgr A* consists of the
candidate PWN G359.95-0.04 and the CHXE, possibly resulting from an unresolved
population of massive CVs with white dwarf masses . Spectral energy distribution analysis suggests that G359.95-0.04 is
likely the hard X-ray counterpart of the ultra-high gamma-ray source HESS
J1745-290, strongly favoring a leptonic origin of the GC TeV emission.Comment: 27 pages. Accepted for publication in the Astrophysical Journa
Extended hard-X-ray emission in the inner few parsecs of the Galaxy
The Galactic Centre hosts a puzzling stellar population in its inner
few parsecs, with a high abundance of surprisingly young, relatively
massive stars bound within the deep potential well of the
central supermassive black hole, Sagittarius A*. Previous
studies suggest that the population of objects emitting soft X-rays
(less than 10 kiloelectronvolts) within the surrounding hundreds
of parsecs, as well as the population responsible for unresolved
X-ray emission extending along the Galactic plane, is dominated
by accreting white dwarf systems. Observations of diffuse hard X-ray
(more than 10 kiloelectronvolts) emission in the inner 10
parsecs, however, have been hampered by the limited spatial resolution
of previous instruments. Here we report the presence of a
distinct hard-X-ray component within the central 4 X 8 parsecs, as
revealed by subarcminute-resolution images in the 20–40 kiloelectronvolt
range. This emission is more sharply peaked towards the
Galactic Centre than is the surface brightness of the soft-X-ray
population. This could indicate a significantly more massive
population of accreting white dwarfs, large populations of lowmass
X-ray binaries or millisecond pulsars, or particle outflows
interacting with the surrounding radiation field, dense molecular
material or magnetic fields. However, all these interpretations pose
significant challenges to our understanding of stellar evolution,
binary formation, and cosmic-ray production in the Galactic
Centre
- …