On the use of local max-ent shape functions for the simulation of forming processes

In this work we review the opportunities given by the use of local maximum-\ud entropy approximants (LME) for the simulation of forming processes. This approximation can\ud be considered as a meshless approximation scheme, and thus presents some appealing features\ud for the numerical simulation of forming processes in a Galerkin framework.\ud Especially the behavior of these shape functions at the boundary is interesting. At nodes\ud on the boundary, the functions possess a weak Kronecker-delta property, hence simplifying the\ud prescription of boundary conditions. Shape functions at the boundary do not overlap internal\ud nodes, nor do internal shape functions overlap nodes at the boundary. Boundary integrals can be\ud computed easily and efficiently compared to for instance moving least-squares approximations.\ud Furthermore, LME shapes also present a controllable degree of smoothness.\ud To test the performance of the LME shapes, an elastic and a elasto-plastic problem was\ud analyzed. The results were compared with a meshless method based on a moving least-squares\ud approximation

Evaluation of Failure behavior of Service Aged Electromagnetic Protective Relays Thesis

Protection systems in medium voltage grids consist for the largest part of protective relays of the electromechanical kind. The first series of this kind of protective relays were introduced in the late 40s. Later kinds (static and numerical) were introduced in the early 70s. For years, these electromechanical protective relays have been serviced to an “as new” condition with a time based maintenance policy (preventive maintenance). This is no longer the case. The influence of no longer servicing to an "as new" condition and the ageing of these relays on the reliability of these relays has not been investigated. For the investigation of failure behavior of electromechanical protective relays, a new evaluation method has been developed. This method is a qualitative method based on Failure Mode Effect and Criticality Analysis

A comparative study on the performance of meshless approximations and their integration

The goal of this research is to study the performance of meshless approximations and their integration. Two diffuse shape functions, namely the moving least-squares and local maximum-entropy function, and a linear triangular interpolation are compared using Gaussian integration and the stabilized conforming nodal integration scheme. The shape functions and integration schemes are tested on two elastic problems, an elasto-plastic problem and the inf-sup test. The elastic computation shows a somewhat lower accuracy for the linear triangular interpolation than for the two diffuse functions with the same number of nodes. However, the computational effort for this interpolation is considerably lower. The accuracy of the calculations in elasto-plasticity depends to great extend on the used integration scheme. All shape functions, and even the linear triangular interpolation, perform very well with the nodal integration scheme and locking-free behavior is shown in the inf-sup test

Rates and determinants of antibiotics and probiotics prescription to children in Asia-Pacific countries

Antibiotic therapy may have important side effects. Guidelines recommend the administration of specific probiotics to reduce the risk of antibiotic-associated diarrhoea (AAD). The rates and determinants of antibiotics and co-prescription of probiotics in children remain poorly known in Asia-Pacific countries, which are very heterogenous in terms of economic development, health care organization and health policies. A survey among general practitioners (GPs) and paediatricians was performed in seven countries of the Asia-Pacific area (Australia, Japan, Indonesia, India, China, Singapore, and South Korea). Physicians completed an online questionnaire that explored their current habits and the determinants for prescribing antibiotics and probiotics. For the 731 physicians who completed the questionnaire (390 paediatricians and 341 GPs), 37% of all consultations for a child led to the prescription of antibiotics (ranging from 17% in Australia to 47% in India). A large majority of physicians (84%) agreed that antibiotics disrupted gut microbiota and considered probiotics an effective intervention to prevent AAD (68%). However, only 33% co-prescribed probiotics with antibiotics (ranging from 13% in Japan to 60% in South Korea). The main reasons for prescribing probiotics were previous episodes of AAD (61%), presence of diarrhoea (55%), prolonged antibiotic treatment (54%) or amoxicillin-clavulanic acid therapy (54%). Although current local guidelines recommend the use of selected probiotics in children receiving antibiotics in Asia-Pacific area, the rates of antibiotics and probiotics prescription significantly vary among countries and are deeply affected by country-related cultural and organisational issues

Renal function in neonates with twin-twin transfusion syndrome treated with or without fetoscopic laser surgery

Research into fetal development and medicin

Enteric Neural Crest Differentiation in Ganglioneuromas Implicates Hedgehog Signaling in Peripheral Neuroblastic Tumor Pathogenesis

Peripheral neuroblastic tumors (PNTs) share a common origin in the sympathetic nervous system, but manifest variable differentiation and growth potential. Malignant neuroblastoma (NB) and benign ganglioneuroma (GN) stand at opposite ends of the clinical spectrum. We hypothesize that a common PNT progenitor is driven to variable differentiation by specific developmental signaling pathways. To elucidate developmental pathways that direct PNTs along the differentiation spectrum, we compared the expression of genes related to neural crest development in GN and NB. In GNs, we found relatively low expression of sympathetic markers including adrenergic biosynthesis enzymes, indicating divergence from sympathetic fate. In contrast, GNs expressed relatively high levels of enteric neuropeptides and key constituents of the Hedgehog (HH) signaling pathway, including Dhh, Gli1 and Gli3. Predicted HH targets were also differentially expressed in GN, consistent with transcriptional response to HH signaling. These findings indicate that HH signaling is specifically active in GN. Together with the known role of HH activity in enteric neural development, these findings further suggested a role for HH activity in directing PNTs away from the sympathetic lineage toward a benign GN phenotype resembling enteric ganglia. We tested the potential for HH signaling to advance differentiation in PNTs by transducing NB cell lines with Gli1 and determining phenotypic and transcriptional response. Gli1 inhibited proliferation of NB cells, and induced a pattern of gene expression that resembled the differential pattern of gene expression of GN, compared to NB (p<0.00001). Moreover, the transcriptional response of SY5Y cells to Gli1 transduction closely resembled the transcriptional response to the differentiation agent retinoic acid (p<0.00001). Notably, Gli1 did not induce N-MYC expression in neuroblastoma cells, but strongly induced RET, a known mediator of RA effect. The decrease in NB cell proliferation induced by Gli1, and the similarity in the patterns of gene expression induced by Gli1 and by RA, corroborated by closely matched gene sets in GN tumors, all support a model in which HH signaling suppresses PNT growth by promoting differentiation along alternative neural crest pathways

Enabling the freight traffic controller for collaborative multi-drop urban logistics: practical and theoretical challenges

There is increasing interest in how horizontal collaboration between parcel carriers might help alleviate problems associated with last-mile logistics in congested urban centers. Through a detailed review of the literature on parcel logistics pertaining to collaboration, along with practical insights from carriers operating in the United Kingdom, this paper examines the challenges that will be faced in optimizing multicarrier, multidrop collection, and delivery schedules. A “freight traffic controller” (FTC) concept is proposed. The FTC would be a trusted third party, assigned to equitably manage the work allocation between collaborating carriers and the passage of vehicles over the last mile when joint benefits to the parties could be achieved. Creating this FTC concept required a combinatorial optimization approach for evaluation of the many combinations of hub locations, network configuration, and routing options for vehicle or walking to find the true value of each potential collaboration. At the same time, the traffic, social, and environmental impacts of these activities had to be considered. Cooperative game theory is a way to investigate the formation of collaborations (or coalitions), and the analysis used in this study identified a significant shortfall in current applications of this theory to last-mile parcel logistics. Application of theory to urban freight logistics has, thus far, failed to account for critical concerns including (a) the mismatch of vehicle parking locations relative to actual delivery addresses; (b) the combination of deliveries with collections, requests for the latter often being received in real time during the round; and (c) the variability in travel times and route options attributable to traffic and road network conditions

Technological Revolution, Sustainability and Development in Africa: Overview, Emerging Issues and Challenges

The paper examines the silent technological revolution in sub‐Saharan Africa focusing on emerging issues and challenges. In view of the centrality of technology diffusion in fostering local innovations and economic development in developing countries, it is surprising that our understanding of the challenges and opportunities in scaling‐up technologies remains limited. This paper capitalises on the ongoing silent technological revolution in sub‐Saharan Africa to present an overview of how new technologies have been adopted and utilised to achieve sustainability. The study identified a host of factors such as weak regulatory enforcement systems, lack of financial credit availability, and limited banking services, which have created conditions for technological innovations such as mobile phone‐based banking, mPedigree, “cardiopad,” and M‐PEPEA to emerge. The public policy implications and directions for future research are identified and examined