63 research outputs found
Alien Registration- Paakkonen, Otto E. (Paris, Oxford County)
https://digitalmaine.com/alien_docs/22264/thumbnail.jp
The 72-Hour WEBT Microvariability Observation of Blazar S5 0716+714 in 2009
Context. The international whole earth blazar telescope (WEBT) consortium
planned and carried out three days of intensive micro-variability observations
of S5 0716+714 from February 22, 2009 to February 25, 2009. This object was
chosen due to its bright apparent magnitude range, its high declination, and
its very large duty cycle for micro-variations. Aims. We report here on the
long continuous optical micro-variability light curve of 0716+714 obtained
during the multi-site observing campaign during which the Blazar showed almost
constant variability over a 0.5 magnitude range. The resulting light curve is
presented here for the first time. Observations from participating
observatories were corrected for instrumental differences and combined to
construct the overall smoothed light curve. Methods. Thirty-six observatories
in sixteen countries participated in this continuous monitoring program and
twenty of them submitted data for compilation into a continuous light curve.
The light curve was analyzed using several techniques including Fourier
transform, Wavelet and noise analysis techniques. Those results led us to model
the light curve by attributing the variations to a series of synchrotron
pulses. Results. We have interpreted the observed microvariations in this
extended light curve in terms of a new model consisting of individual
stochastic pulses due to cells in a turbulent jet which are energized by a
passing shock and cool by means of synchrotron emission. We obtained an
excellent fit to the 72-hour light curve with the synchrotron pulse model
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
Context: Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown. Objective: To investigate how SAT mitochondria change following diet-induced and bariatric surgery-induced weight-loss interventions in 4 independent weight-loss studies. Methods: The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up. Results: Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: -8.7 following LCD, -4.4 following weight maintenance; CRYO: IPA z-score: -5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001). Conclusions: Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.Peer reviewe
Situational awareness and information flow in prehospital emergency medical care from the perspective of paramedic field supervisors: a scenario-based study
The adoption of pottery on Kodiak Island: Insights from organic residue analysis
Pottery technology, originating in Northeast Asia, appeared in Alaska some 2800 years ago. It spread swiftly along Alaska’s coastline but was not adopted on Kodiak Island until around 500 cal BP, as part of the Koniag tradition. While in the southeast pottery was used extensively, people on the northern half of the island did not adopt the technology. What drove these patterns of adoption and non-adoption on Kodiak Island? To better understand the role of ceramic technology in the Koniag tradition we used organic residue analysis to investigate pottery function. Results indicate that pottery was used to process aquatic resources, including anadromous fish, but especially marine species. Based on archaeological and ethnographic data, and spatial analysis of pottery distributions and function, we hypothesize that Koniag pottery was a tool inherent to the rendering of whale oil on the southeast coast of Kodiak Island, supporting previous suggestions by Knecht (1995) and Fitzhugh (2001). When viewed in the broader historical context of major technological and social transformations, we conclude that social identity and cultural boundaries may also have played a role in the delayed and partial adoption of pottery on Kodiak Island
Proteins on the catwalk: modelling the structural domains of the CCN family of proteins
The CCN family of proteins (CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6) are multifunctional mosaic proteins that play keys roles in crucial areas of physiology such as angiogenesis, skeletal development tumourigenesis, cell proliferation, adhesion and survival. This expansive repertoire of functions comes through a modular structure of 4 discrete domains that act both independently and in concert. How these interactions with ligands and with neighbouring domains lead to the biological effects is still to be explored but the molecular structure of the domains is likely to play an important role in this. In this review we have highlighted some of the key features of the individual domains of CCN family of proteins based on their biological effects using a homology modelling approach
Meta-transcriptomics indicates biotic cross-tolerance in willow trees cultivated on petroleum hydrocarbon contaminated soil
Alien Registration- Paakkonen, Otto E. (Paris, Oxford County)
https://digitalmaine.com/alien_docs/22264/thumbnail.jp
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