Biminimal immersions

We study biminimal immersions, that is immersions which are critical points of the bienergy for normal variations with fixed energy. We give a geometrical description of the Euler-Lagrange equation associated to biminimal immersions for: i) biminimal curves in a Riemannian manifold, with particular care to the case of curves in a space form ii) isometric immersions of codimension one in a Riemannian manifold, in particular for surfaces of a three-dimensional manifold. We describe two methods to construct families of biminimal surfaces using both Riemannian and horizontally homothetic submersions.Comment: Dedicated to Professor Renzo Caddeo on his 60th birthday. 2 figure

The COVID-19 Wellbeing Study: Examining perceived coercion and psychological wellbeing during the COVID-19 pandemic by means of an online survey, asynchronous virtual focus groups and individual interviews – a protocol

Introduction: The COVID-19 pandemic has resulted in many countries applying restrictive measures, such as lockdown, to contain and prevent further spread. The psychological impact of lockdown and working as a healthcare worker on the frontline has been chronicled in studies pertaining to previous infectious disease pandemics that have reported the presence of depressive symptoms, anxiety, insomnia, and post-traumatic stress symptoms. Potentially linked to psychological well-being and not yet studied is the possibility that lockdown and working on the frontline of the pandemic are associated with perceptions of coercion. Methods and analysis: The present study aimed to examine perceived coercion in those who have experienced COVID-19-related lockdown and/or worked as a frontline healthcare worker across three European countries. It aimed to describe how such perceptions may impact on psychological well-being, coping and posttraumatic growth. It will employ an explanatory mixedmethods research methodology consisting of an online survey and online asynchronous virtual focus groups (AVFGs) and individual interviews. χ2 tests and analyses of variance will be used to examine whether participants from different countries differ according to demographic factors, whether there are differences between cohorts on perceived coercion, depression, anxiety and post-traumatic growth scores. The relationship between coercion and symptoms of distress will be assessed using multiple regression. Both the AVFGs and the narrative interviews will be analysed using thematic narrative analysis. Ethics and dissemination: The study has been approved by University College London’s Research Ethics Committee under Project ID Number 7335/004. Results will be disseminated by means of peer-reviewed publications and at national and/or international conferences

Significant modifications of the salivary proteome potentially associated with complications of Down syndrome revealed by top-down proteomics

People with Down syndrome, a frequent genetic disorder in humans, have increased risk of health problems associated with this condition. One clinical feature of Down syndrome is the increased prevalence and severity of periodontal disease in comparison with the general population. Because saliva plays an important role in maintaining oral health, in the present study the salivary proteome of Down syndrome subjects was investigated to explore modifications with respect to healthy subjects. Whole saliva of 36 Down syndrome subjects, divided in the age groups 10-17 yr and 18-50 yr, was analyzed by a top-down proteomic approach, based on the high performance liquid chromatography-electrospray ionization-MS analysis of the intact proteins and peptides, and the qualitative and quantitative profiles were compared with sex- and age-matched control groups. The results showed the following interesting features: 1) as opposed to controls, in Down syndrome subjects the concentration of the major salivary proteins of gland origin did not increase with age; as a consequence concentration of acidic proline rich proteins and S cystatins were found significantly reduced in older Down syndrome subjects with respect to matched controls; 2) levels of the antimicrobial α-defensins 1 and 2 and histatins 3 and 5 were significantly increased in whole saliva of older Down syndrome subjects with respect to controls; 3) S100A7, S100A8, and S100A12 levels were significantly increased in whole saliva of Down syndrome subjects in comparison with controls. The increased level of S100A7 and S100A12 may be of particular interest as a biomarker of early onset Alzheimer's disease, which is frequently associated with Down syndrome

Opportunities and challenges from the use of genomic selection for beef cattle breeding in Latin America

In 2009, Latin American countries had approximately 401 million cattle (29% of the world’s total cattle population) and produced 8.2 million tonnes of beef, equivalent to 29% of the world’s total production (FAO, 2011). Beef in Latin American countries is produced under widely differing climates (ranging from tropical to temperate), resources available (vegetation, food), types of markets, and genetic backgrounds of the animals. The main production systems are classified as beef and dual-purpose cattle. The genetic backgrounds of animals vary from purebred European (Bos taurus taurus) or Zebu (Bos taurus indicus) to crossbreeds (Figures 1 and 2). Beef production systems may also be characterized by their management intensification levels as grazing only, grazing with food supplementation, and feedlot production. The main beef-producing countries are Brazil (51.6% of the total Latin American beef production), Argentina (18.5%), Mexico (9.4%), and Colombia (5.1%). Other countries contributing more than 1% of the total regional production are Uruguay, Venezuela, Paraguay, Bolivia, Ecuador, and Chile (Table 1). Latin America is a region of the world that can significantly increase its production in response to beef demand. Brazil has a mature beef cattle industry based on grass-fed cattle, in which feeding B. taurus indicus cattle, especially the Nellore breed, is a common practice. Over the last 8 years, beef production in Brazil has become one of the most important activities for employment and wealth creation. Foot-and-mouth disease issues are still a factor limiting the increase in Latin American beef exports (Ferraz and de Felício, 2010; Domingues Millen et al., 2011). Only a few Latin American countries, including Chile and Mexico, have the status of being free of this disease without vaccination. In most countries, the disease is controlled using a combination of free areas without vaccination and areas with vaccination. Other countries with a strong B. taurus indicus background in their beef cattle populations are those with large tropical areas dedicated to beef cattle production, such as Colombia, Venezuela, and Paraguay. Beef production in Argentina, Chile, Uruguay, and some portions of Brazil and Mexico is based mainly around the production of B. taurus taurus cattle (Peel et al., 2010; Arelovich et al., 2011; Domingues Millen et al., 2011). The Mexican beef cattle industry consists of 2 nearly separate market components. Beef producers in the northern part of Mexico have largely focused on the production of calves for export to the United States (Galyean et al., 2011). European beef genetics have been widely used in the region, beginning with importations of Hereford cattle and continuing with today’s popularity of Angus and Brangus along with several continental breeds, such as Charolais and Simmental. The central and southern regions of Mexico have historically produced grass-fed beef for the national market as well as dual-purpose dairy-Zebu crossbred cattle to produce milk and beef (Peel et al., 2010). Currently, breeding programs for the genetic evaluation of beef cattle in Latin America are based on statistical analyses in which performance and pedigree information are integrated. These analyses are based on a mixed model methodology, in particular the animal model statistical approach using best linear unbiased prediction methods to obtain estimated breeding values (EBV) for economically important traits. This methodology for obtaining EBV has been set up in Argentina, Brazil, Colombia, Mexico, Uruguay, Venezuela, and other countries. It has been established for specific purebred populations and also for some crossbred populations, such as multibreed populations with a dual purpose (beef and milk) in the Latin American humid tropics, which involve animals crossbred between B. taurus taurus and B. taurus indicus and composite breeds. Most programs focus on evaluating growth and reproductive traits, although a few have included longevity (stayability), heifer pregnancy, conformation, and carcass and meat quality traits

Seismic hazard data for the new, Italian building code based on European standard

Prior to 2003 the Italian building code, established in 1974, was mostly based on working stress design. The zonation that guided its application was made up in 1981 using a semi-quantitative, mainly seismological approach; it was enforced in 1984 and left about 2/3 of the territory without seismic provisions. In 1998 a new zonation was proposed but never adopted. The 2002 Mw5.7 earthquake in Molise (Southern Italy) caused the collapse of a school and the death of 26 children. The school was built in an area where seismic provisions were not applied, although the zonation proposed in 1998 assigned it to the second zone. The earthquake triggered a process that led in a few months to a new set of seismic provision

NK cells and other innate lymphoid cells in hematopoietic stem cell transplantation

Natural killer (NK) cells play a major role in the T-cell depleted haploidentical hematopoietic stem cell transplantation (haplo-HSCT) to cure high-risk leukemias. NK cells belong to the expanding family of innate lymphoid cells (ILCs). At variance with NK cells, the other ILC populations (ILC1/2/3) are non-cytolytic, while they secrete different patterns of cytokines. ILCs provide host defenses against viruses, bacteria, and parasites, drive lymphoid organogenesis, and contribute to tissue remodeling. In haplo-HSCT patients, the extensive T-cell depletion is required to prevent graft-versus-host disease (GvHD) but increases risks of developing a wide range of life-threatening infections. However, these patients may rely on innate defenses that are reconstituted more rapidly than the adaptive ones. In this context, ILCs may represent important players in the early phases following transplantation. They may contribute to tissue homeostasis/remodeling and lymphoid tissue reconstitution. While the reconstitution of NK cell repertoire and its role in haplo-HSCT have been largely investigated, little information is available on ILCs. Of note, CD34+ cells isolated from different sources of HSC may differentiate in vitro toward various ILC subsets. Moreover, cytokines released from leukemia blasts (e.g., IL-1β) may alter the proportions of NK cells and ILC3, suggesting the possibility that leukemia may skew the ILC repertoire. Further studies are required to define the timing of ILC development and their potential protective role after HSCT