The Foggy Dew

https://digitalcommons.library.umaine.edu/mmb-vp/5859/thumbnail.jp

The enhanced Software Life Cyle Support Environment (ProSLCSE): Automation for enterprise and process modeling

In this paper, we have introduced a comprehensive method for enterprise modeling that addresses the three important aspects of how an organization goes about its business. FirstEP includes infrastructure modeling, information modeling, and process modeling notations that are intended to be easy to learn and use. The notations stress the use of straightforward visual languages that are intuitive, syntactically simple, and semantically rich. ProSLCSE will be developed with automated tools and services to facilitate enterprise modeling and process enactment. In the spirit of FirstEP, ProSLCSE tools will also be seductively easy to use. Achieving fully managed, optimized software development and support processes will be long and arduous for most software organizations, and many serious problems will have to be solved along the way. ProSLCSE will provide the ability to document, communicate, and modify existing processes, which is the necessary first step

Matrix isolation study of the photolysis of cyanogen azide. The infrared and ultraviolet spectra of the free radical NCN

Infrared and ultraviolet absorption spectra of free radical in photolysis of cyanogen azid

The pharmacology and function of receptors for short-chain fatty acids

Despite some blockbuster G protein–coupled receptor (GPCR) drugs, only a small fraction (∼15%) of the more than 390 nonodorant GPCRs have been successfully targeted by the pharmaceutical industry. One way that this issue might be addressed is via translation of recent deorphanization programs that have opened the prospect of extending the reach of new medicine design to novel receptor types with potential therapeutic value. Prominent among these receptors are those that respond to short-chain free fatty acids of carbon chain length 2–6. These receptors, FFA2 (GPR43) and FFA3 (GPR41), are each predominantly activated by the short-chain fatty acids acetate, propionate, and butyrate, ligands that originate largely as fermentation by-products of anaerobic bacteria in the gut. However, the presence of FFA2 and FFA3 on pancreatic β-cells, FFA3 on neurons, and FFA2 on leukocytes and adipocytes means that the biologic role of these receptors likely extends beyond the widely accepted role of regulating peptide hormone release from enteroendocrine cells in the gut. Here, we review the physiologic roles of FFA2 and FFA3, the recent development and use of receptor-selective pharmacological tool compounds and genetic models available to study these receptors, and present evidence of the potential therapeutic value of targeting this emerging receptor pair

Analysis of the Assistant Principal at Johns Hill Middle School

Introduction The improvement of teaching and learning is a foremost function of the middle school assistant principal. An important factor in determining the success or failure of a middle school is the ability of the assistant principal to lead the staff in the improvement of the school\u27s curricular programs. Working with individuals and groups of teachers to improve staff relations is a demanding job that requires the assistant principal to develop a broad set of skills and various attitudes. Educators who do not understand the behavior of children will be in a very unfavorable situation. The assistant principal who does not effectively help the staff develop a better understanding of the nature of children will have to correct this difficult concern. The assistant principal who can effectively help the staff develop a better understanding of the children will find fewer problems. This will allow the staff to devote more time and energy to teaching the children. Helping the staff understand the behaviors of children must be one of the assistant principal\u27s chief concerns. Statement of the Problem This field experience study will attempt to answer the question: How can the middle school assistant principal improve the relations of the staff to better teach the children? Need for the Study Administrators involved in improving staff relations in the teaching of children will find this field experience study beneficial in their approach to this concern. Purpose of the Study This field experience is to assist the school administrator, especially the middle school assistant principal, in improving staff relations in the teaching of children. One objective of education today is to help students to live a productive and satisfying life. The school must recognize the differences of the students. It is the obligation of the administrator, the middle school assistant principal, to help the staff understand these unique students for the purpose of teaching these children. As assistant principal of Johns Hill Middle School in Decatur, Illinois, this field experience study will focus on one middle school and one assistant principal. The study will examine the relationships of this assistant principal and the concerns of improving staff relations at Johns Hill Middle School. Delimitations The following delimitations are appropriate for this field experience study: This study examines the role of assistant principal with respect to improving staff relations in the teaching of children. This study examines the role of the teacher with respect to improving staff relations in the teaching of children. This study examines the role of the beginning teacher with respect to improving staff relations in the teaching of children. This study examines the role of the teacher aide with respect to improving staff relations in the teaching of children. This study examines the role of the substitute teacher with respect to improving staff relations in the teaching of children. This study focuses on one assistant principal, Craig E. Milligan, and one school, Johns Hill Middle School, in Decatur, Illinois

Analysis of the Assistant Principal at Johns Hill Middle School

Introduction The improvement of teaching and learning is a foremost function of the middle school assistant principal. An important factor in determining the success or failure of a middle school is the ability of the assistant principal to lead the staff in the improvement of the school\u27s curricular programs. Working with individuals and groups of teachers to improve staff relations is a demanding job that requires the assistant principal to develop a broad set of skills and various attitudes. Educators who do not understand the behavior of children will be in a very unfavorable situation. The assistant principal who does not effectively help the staff develop a better understanding of the nature of children will have to correct this difficult concern. The assistant principal who can effectively help the staff develop a better understanding of the children will find fewer problems. This will allow the staff to devote more time and energy to teaching the children. Helping the staff understand the behaviors of children must be one of the assistant principal\u27s chief concerns. Statement of the Problem This field experience study will attempt to answer the question: How can the middle school assistant principal improve the relations of the staff to better teach the children? Need for the Study Administrators involved in improving staff relations in the teaching of children will find this field experience study beneficial in their approach to this concern. Purpose of the Study This field experience is to assist the school administrator, especially the middle school assistant principal, in improving staff relations in the teaching of children. One objective of education today is to help students to live a productive and satisfying life. The school must recognize the differences of the students. It is the obligation of the administrator, the middle school assistant principal, to help the staff understand these unique students for the purpose of teaching these children. As assistant principal of Johns Hill Middle School in Decatur, Illinois, this field experience study will focus on one middle school and one assistant principal. The study will examine the relationships of this assistant principal and the concerns of improving staff relations at Johns Hill Middle School. Delimitations The following delimitations are appropriate for this field experience study: This study examines the role of assistant principal with respect to improving staff relations in the teaching of children. This study examines the role of the teacher with respect to improving staff relations in the teaching of children. This study examines the role of the beginning teacher with respect to improving staff relations in the teaching of children. This study examines the role of the teacher aide with respect to improving staff relations in the teaching of children. This study examines the role of the substitute teacher with respect to improving staff relations in the teaching of children. This study focuses on one assistant principal, Craig E. Milligan, and one school, Johns Hill Middle School, in Decatur, Illinois

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the present work, we explored whether a RASSL of the free fatty acid receptor 2 (FFA2) could be developed on the basis of pharmacological variation between species orthologs. For this, bovine FFA2 was characterized, revealing distinct ligand selectivity compared with human FFA2. Homology modeling and mutational analysis demonstrated a single mutation in human FFA2 of C4.57G resulted in a human FFA2 receptor with ligand selectivity similar to the bovine receptor. This was exploited to generate human FFA2-RASSL by the addition of a second mutation at a known orthosteric ligand interaction site, H6.55Q. The resulting FFA2-RASSL displayed a >100-fold loss of activity to endogenous ligands, while responding to the distinct ligand sorbic acid with pEC(50) values for inhibition of cAMP, 5.83 ± 0.11; Ca(2+) mobilization, 4.63 ± 0.05; ERK phosphorylation, 5.61 ± 0.06; and dynamic mass redistribution, 5.35 ± 0.06. This FFA2-RASSL will be useful in future studies on this receptor and demonstrates that exploitation of pharmacological variation between species orthologs is a powerful method to generate novel chemically engineered GPCRs

We Could, but Should We? Ethical Considerations for Providing Access to GeoCities and Other Historical Digital Collections

We live in an era in which the ways that we can make sense of our past are evolving as more artifacts from that past become digital. At the same time, the responsibilities of traditional gatekeepers who have negotiated the ethics of historical data collection and use, such as librarians and archivists, are increasingly being sidelined by the system builders who decide whether and how to provide access to historical digital collections, often without sufficient reflection on the ethical issues at hand. It is our aim to better prepare system builders to grapple with these issues. This paper focuses discussions around one such digital collection from the dawn of the web, asking what sorts of analyses can and should be conducted on archival copies of the GeoCities web hosting platform that dates to 1994.This research was supported by the Natural Sciences and Engineering Research Council of Canada, the Social Sciences and Humanities Research Council of Canada, the US National Science Foundation (grants 1618695 and 1704369), the Andrew W. Mellon Foundation, Start Smart Labs, and Compute Canada

Matrix isolation study of the reaction of f atoms with co infrared and ultraviolet spectrum of the free radical fco

Matrix isolation of reaction of fluorine atoms with carbon monoxide - infrared and ultraviolet spectrum of free radical fluorocarbon monoxid