598 research outputs found
Structural transition in interdependent networks with regular interconnections
Networks are often made up of several layers that exhibit diverse degrees of
interdependencies. A multilayer interdependent network consists of a set of
graphs that are interconnected through a weighted interconnection matrix , where the weight of each inter-graph link is a non-negative real number . Various dynamical processes, such as synchronization, cascading failures
in power grids, and diffusion processes, are described by the Laplacian matrix
characterizing the whole system. For the case in which the multilayer
graph is a multiplex, where the number of nodes in each layer is the same and
the interconnection matrix , being the identity matrix, it has
been shown that there exists a structural transition at some critical coupling,
. This transition is such that dynamical processes are separated into
two regimes: if , the network acts as a whole; whereas when , the network operates as if the graphs encoding the layers were isolated. In
this paper, we extend and generalize the structural transition threshold to a regular interconnection matrix (constant row and column sum).
Specifically, we provide upper and lower bounds for the transition threshold in interdependent networks with a regular interconnection matrix
and derive the exact transition threshold for special scenarios using the
formalism of quotient graphs. Additionally, we discuss the physical meaning of
the transition threshold in terms of the minimum cut and show, through
a counter-example, that the structural transition does not always exist. Our
results are one step forward on the characterization of more realistic
multilayer networks and might be relevant for systems that deviate from the
topological constrains imposed by multiplex networks.Comment: 13 pages, APS format. Submitted for publicatio
A network approach for power grid robustness against cascading failures
Cascading failures are one of the main reasons for blackouts in electrical
power grids. Stable power supply requires a robust design of the power grid
topology. Currently, the impact of the grid structure on the grid robustness is
mainly assessed by purely topological metrics, that fail to capture the
fundamental properties of the electrical power grids such as power flow
allocation according to Kirchhoff's laws. This paper deploys the effective
graph resistance as a metric to relate the topology of a grid to its robustness
against cascading failures. Specifically, the effective graph resistance is
deployed as a metric for network expansions (by means of transmission line
additions) of an existing power grid. Four strategies based on network
properties are investigated to optimize the effective graph resistance,
accordingly to improve the robustness, of a given power grid at a low
computational complexity. Experimental results suggest the existence of
Braess's paradox in power grids: bringing an additional line into the system
occasionally results in decrease of the grid robustness. This paper further
investigates the impact of the topology on the Braess's paradox, and identifies
specific sub-structures whose existence results in Braess's paradox. Careful
assessment of the design and expansion choices of grid topologies incorporating
the insights provided by this paper optimizes the robustness of a power grid,
while avoiding the Braess's paradox in the system.Comment: 7 pages, 13 figures conferenc
A Topological Investigation of Phase Transitions of Cascading Failures in Power Grids
Cascading failures are one of the main reasons for blackouts in electric
power transmission grids. The economic cost of such failures is in the order of
tens of billion dollars annually. The loading level of power system is a key
aspect to determine the amount of the damage caused by cascading failures.
Existing studies show that the blackout size exhibits phase transitions as the
loading level increases. This paper investigates the impact of the topology of
a power grid on phase transitions in its robustness. Three spectral graph
metrics are considered: spectral radius, effective graph resistance and
algebraic connectivity. Experimental results from a model of cascading failures
in power grids on the IEEE power systems demonstrate the applicability of these
metrics to design/optimize a power grid topology for an enhanced phase
transition behavior of the system
Transcatheter tricuspid valve-in-ring placement: complex valve obstruction by hypo-attenuating leaflet thickening, hypo-attenuation affecting motion, and native tricuspid valve remnant
SARS-CoV2 (COVID-19) infection: is fetal surgery in times of national disasters reasonable?
Even though the global COVID‐19 pandemic may affect how medical care is delivered in general, most countries try to maintain steady access for women to routine pregnancy care, including fetal anomaly screening. This means that, also during this pandemic, fetal anomalies will be detected, and that discussions regarding invasive genetic testing and possibly fetal therapy will need to take place. For patients, concerns about Severe Acute Respiratory Syndrome‐Corona Virus 2 will add to the anxiety caused by the diagnosis of a serious fetal anomaly. Yet, also for fetal medicine teams the situation gets more complex as they must weigh up the risks and benefits to the fetus as well as the mother, while managing a changing evidence base and logistic challenges in their healthcare system
Epidemic processes in complex networks
In recent years the research community has accumulated overwhelming evidence
for the emergence of complex and heterogeneous connectivity patterns in a wide
range of biological and sociotechnical systems. The complex properties of
real-world networks have a profound impact on the behavior of equilibrium and
nonequilibrium phenomena occurring in various systems, and the study of
epidemic spreading is central to our understanding of the unfolding of
dynamical processes in complex networks. The theoretical analysis of epidemic
spreading in heterogeneous networks requires the development of novel
analytical frameworks, and it has produced results of conceptual and practical
relevance. A coherent and comprehensive review of the vast research activity
concerning epidemic processes is presented, detailing the successful
theoretical approaches as well as making their limits and assumptions clear.
Physicists, mathematicians, epidemiologists, computer, and social scientists
share a common interest in studying epidemic spreading and rely on similar
models for the description of the diffusion of pathogens, knowledge, and
innovation. For this reason, while focusing on the main results and the
paradigmatic models in infectious disease modeling, the major results
concerning generalized social contagion processes are also presented. Finally,
the research activity at the forefront in the study of epidemic spreading in
coevolving, coupled, and time-varying networks is reported.Comment: 62 pages, 15 figures, final versio
República: Año III Número 387 - (14/11/33)
PURPOSE OF REVIEW: The purpose of this study was to investigate the association of 26 inflammatory biomarkers (acute phase proteins, cytokines, chemokines) and renal markers with coronary lipid core burden index (LCBI) assessed by near-infrared spectroscopy (NIRS) imaging, as well as the association of these biomarkers with long-term cardiovascular outcome. RECENT FINDINGS: NIRS-derived LCBI has recently been shown to be an independent predictor of major adverse cardiac events (MACE). However, studies on the association between circulating biomarkers and NIRS-derived characteristics have not yet been performed. Between 2008 and 2011, 581 patients underwent diagnostic coronary angiography or percutaneous coronary intervention for stable angina pectoris or acute coronary syndrome (ACS). NIRS of a non-culprit vessel was performed in a subset of 203 patients. In multivariable analyses, TNF-alpha tended to be associated with higher LCBI (beta 0.088 ln (pg/ml) increase per unit LCBI; 95% CI 0.000-0.177, p = 0.05) after adjustment for clinical characteristics. However, this association did not persist after Bonferroni correction (statistical threshold 0.0019). Major adverse cardiac events (MACE) were registered in 581 patients during a median follow-up time of 4.7 years (IQR: [4.2-5.6] years). After adjustment for clinical characteristics and Bonferroni correction, IL-8 (HR 1.60; 95% CI [1.18-2.17] per ln (pg/ml), p = 0.002) was borderline associated with MACE and significantly associated with all-cause mortality or ACS (HR 1.75; 95% CI [1.24-2.48] per ln (pg/ml), p = 0.0015). In conclusion, we found that IL-8 was independently associated with clinical outcome, but altogether, the multiplex panel we investigated here did not render a useful blood biomarker of high LCBI
Outcome predictors for maternal red blood cell alloimmunisation with anti-K and anti-D managed with intrauterine blood transfusion
Red blood cell (RBC) alloimmunisation with anti-D and anti-K comprise the majority of cases of fetal haemolytic disease requiring intrauterine red cell transfusion (IUT). Few studies have investigated which haematological parameters can predict adverse fetal or neonatal outcomes. The aim of the present study was to identify predictors of adverse outcome, including preterm birth, intrauterine fetal demise (IUFD), neonatal death (NND) and/or neonatal transfusion. We reviewed the records of all pregnancies alloimmunised with anti-K and anti-D, requiring IUT over 27 years at a quaternary fetal centre. We reviewed data for 128 pregnancies in 116 women undergoing 425 IUTs. The median gestational age (GA) at first IUT was significantly earlier for anti-K than for anti-D (24·3 vs. 28·7 weeks, P = 0·004). Women with anti-K required more IUTs than women with anti-D (3·84 vs. 3·12 mean IUTs, P = 0·036) and the fetal haemoglobin (Hb) at first IUT was significantly lower (51.0 vs. 70.5 g/l, P = 0·001). The mean estimated daily decrease in Hb did not differ between the two groups. A greater number of IUTs and a slower daily decrease in Hb (g/l/day) between first and second IUTs were predictive of a longer period in utero. Earlier GA at first IUT and a shorter interval from the first IUT until delivery predicted IUFD/NND. Earlier GA and lower Hb at first IUT significantly predicted need for phototherapy and/or blood product use in the neonate. In the anti-K group, a greater number of IUTs was required in women with a higher titre. Furthermore, the higher the titre, the earlier the GA at which an IUT was required in both groups. The rate of fall in fetal Hb between IUTs decreased, as the number of transfusions increased. Our present study identified pregnancies at considerable risk of an unfavourable outcome with anti-D and anti-K RBC alloimmunisation. Identifying such patients can guide pregnancy management, facilitates patient counselling, and can optimise resource use. Prospective studies can also incorporate these characteristics, in addition to laboratory markers, to further identify and improve the outcomes of these pregnancies
Multi-Layer Cyber-Physical Security and Resilience for Smart Grid
The smart grid is a large-scale complex system that integrates communication
technologies with the physical layer operation of the energy systems. Security
and resilience mechanisms by design are important to provide guarantee
operations for the system. This chapter provides a layered perspective of the
smart grid security and discusses game and decision theory as a tool to model
the interactions among system components and the interaction between attackers
and the system. We discuss game-theoretic applications and challenges in the
design of cross-layer robust and resilient controller, secure network routing
protocol at the data communication and networking layers, and the challenges of
the information security at the management layer of the grid. The chapter will
discuss the future directions of using game-theoretic tools in addressing
multi-layer security issues in the smart grid.Comment: 16 page
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