Development of comprehension of ironic utterances in 3-to 9-year-old Finnish-speaking children

Abstract This study explores the comprehension of simple ironic utterances in 210 Finnish children aged from 3 to 9 years. If the child answered the question correctly, he/she was asked to explain correct answers. The results indicated that there was large individual variation within age groups both in answers and explanations. In terms of correct answers there was a significant difference between 6-and 7-year-olds and in correct explanations between age groups of 3-4, 6-7 and 7-8. Analysis of incorrect answers showed that literal interpretation of an utterance was the most common incorrect answer type in all age groups. Totally irrelevant answers occurred only in children aged 3 and 4. In terms of incorrect explanations, "turntaking" and "incorrect focus" categories were the most common incorrect explanation types. Contrary to previous studies, in this study already some of the 3-and 4-year-olds showed an emerging ability to comprehend irony. This study explores the comprehension of simple ironic utterances in 210 Finnish children aged from 3 to 9 years. If the child answered the question correctly, he/she was asked to explain correct answers. The results indicated that there was large individual variation within age groups both in answers and explanations. In terms of correct answers there was a significant difference between 6-and 7-year-olds and in correct explanations between age groups of 3-4, 6-7 and 7-8. Analysis of incorrect answers showed that literal interpretation of an utterance was the most common incorrect answer type in all age groups. Totally irrelevant answers occurred only in children aged 3 and 4. In terms of incorrect explanations, "turntaking" and "incorrect focus" categories were the most common incorrect explanation types. Contrary to previous studies, in this study already some of the 3-and 4-year-olds showed an emerging ability to comprehend irony

Ydinräjähteiden ja muiden uusimpien taisteluvälineiden vaikutus maavoimien toimintaan olosuhteissamme

Artikkelin johdannossa todetaan, että maavoimien kehityksessä on meneillään murroskausi. Se aiheutuu uusista taisteluvälineistä, joita tekniikka on tuottanut nopeassa tahdissa taistelukäyttöön. "Nämä uudet taisteluvälineet - lähinnä ns. ydinräjähteet - ovat kaikkia tähän asti käytettyjä taisteluvälineitä niin paljon tehokkaampia, että taistelun ja koko sodankäynnin luonne muuttuu, jos ne otetaan käyttöön , ja että muutoksia niistä aiheutuu silloin myös itse maavoimiin." Ydinaseiden käyttö todetaan epätodennäköiseksi, mutta niiden käyttöön on kuitenkin syytä varautua. Toimivan ja luottamusta herättävän ilmasuojelun ja väestösuojelun merkityksen todetaan kasvaneen. Ensimmäisessä luvussa esitellään ydinräjähteet ja muut uusimmat taisteluvälineet, käsitellen muun muassa seikkaperäisesti erilaisten ydinräjähdyksien ominaisuuksia, vaikutuksia jne. Lisäksi ominaisuuksia tarkastellaan lyhyesti taktisesta näkökulmasta. Toisessa luvussa, "Johtaminen", käsitellään johtajalle asetettavia vaatimuksia, tilannetietoisuutta ja tehtävän suorittamista korostaen muun muassa oma-aloitteisuuden merkitystä. Lisäksi käsitellään yleisiä johtamisperiaatteita uusien aseiden vaikutuspiirissä. Seuraavissa luvuissa käsitellään uusien aseiden vaikutusta siirtymisiin sekä puolustuksen ja hyökkäyksen järjestelyihin. Kuudes luku käsittelee organisaation muodostamista liikkuvuuden, tulivoiman, suojan sekä huollon näkökulmasta. Lisäksi tarkastelussa ovat mukana joukkojen ja johtoportaiden kokoonpanot ja vahvuudet. Loppusanoissa korostetaan muun muassa koulutuksen merkitystä varauduttaessa uusien aseiden mahdolliseen käyttöön

Status report of the JYFL-ECR ion sources

"Ion beam cocktails" are mixtures of ions with near-identical charge-to-mass ratios. In conjunction with the JYFL-ECRIS, the K130-cyclotron acts as a mass analyzer: the switch from one ion to another within the same cocktail is simple and fast. In the case of the first ion beam cocktail, the oxygen and argon gases were mixed into the gas feed line. At the same time the magnesium and iron ion beams were produced using the MIVOC method. Magnesocene and ferrocene compounds were both mixed into the MIVOC chamber. This capability is especially useful in the study of single event effects (SEE) in space electronics. All gaseous elements from H to Xe can be produced. The non-gaseous elements produced so far are C, Mg, Al, Si, S, Ca, Ti, Cr, Fe, Co, Ni, Cu, Zn and Ge. A major technical modification since the construction (in 1990) of the JYFL-ECRIS was made in January 98: a negatively biased disc replaces now the first plasma stage. After a couple of months experience with the modified source the change was found to be towards a correct direction. The source is now much easier to use and the good operating conditions are well repeated. A real advantage is the new magnetic field settings which are practically the same for all kind of beams, gaseous and solids. Due to the requirements of ion beams with higher charges and heavier elements than the present JYFL-ECRIS can produce, JYFL decided to begin a design and construction project of a new ECR ion source, called as ECRIS 2. The project aims to a source that is based mainly on the design of the 14 GHz AECR-U source at the LBNL. Some modifications made into the similar source under construction at the NSCL/MSU will be utilized here. The new source will be installed horizontally in the basement of the ECRIS laboratory. It requires a new beam-line from the source to the cyclotron injection line, since the old vertically located JYFL-ECRIS will be preserved in operation. The new source is planned to be operational during the year 2000

Quantifying single nucleotide variant detection sensitivity in exome sequencing

BACKGROUND: The targeted capture and sequencing of genomic regions has rapidly demonstrated its utility in genetic studies. Inherent in this technology is considerable heterogeneity of target coverage and this is expected to systematically impact our sensitivity to detect genuine polymorphisms. To fully interpret the polymorphisms identified in a genetic study it is often essential to both detect polymorphisms and to understand where and with what probability real polymorphisms may have been missed. RESULTS: Using down-sampling of 30 deeply sequenced exomes and a set of gold-standard single nucleotide variant (SNV) genotype calls for each sample, we developed an empirical model relating the read depth at a polymorphic site to the probability of calling the correct genotype at that site. We find that measured sensitivity in SNV detection is substantially worse than that predicted from the naive expectation of sampling from a binomial. This calibrated model allows us to produce single nucleotide resolution SNV sensitivity estimates which can be merged to give summary sensitivity measures for any arbitrary partition of the target sequences (nucleotide, exon, gene, pathway, exome). These metrics are directly comparable between platforms and can be combined between samples to give “power estimates” for an entire study. We estimate a local read depth of 13X is required to detect the alleles and genotype of a heterozygous SNV 95% of the time, but only 3X for a homozygous SNV. At a mean on-target read depth of 20X, commonly used for rare disease exome sequencing studies, we predict 5–15% of heterozygous and 1–4% of homozygous SNVs in the targeted regions will be missed. CONCLUSIONS: Non-reference alleles in the heterozygote state have a high chance of being missed when commonly applied read coverage thresholds are used despite the widely held assumption that there is good polymorphism detection at these coverage levels. Such alleles are likely to be of functional importance in population based studies of rare diseases, somatic mutations in cancer and explaining the “missing heritability” of quantitative traits

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus

Background Health-related quality of life (HRQoL) is severely impaired in persons with idiopathic normal pressure hydrocephalus (iNPH). The HRQoL improves in a number of patients after the placement of a cerebrospinal fluid (CSF) shunt, but long-term follow-up of HRQoL is rare. Methods Extended follow-up (60 months) of a prospective cohort study involving 189 patients with iNPH who underwent shunt surgery. Preoperative variables were used to predict favorable HRQoL outcome (improvement or non-deterioration) measured by the 15D instrument 5 years after shunting. Results Out of the 189 initially enrolled study participants, 88 had completed 5-year HRQoL follow-up (46%), 64 had died (34%), and 37 (20%) failed to complete the HRQoL follow-up but were alive at the end of the study. After initial post-operative HRQoL improvement, HRQoL deteriorated so that 37/88 participants (42%) had a favorable HRQoL outcome 5 years after shunting. Multivariate binary logistic regression analysis indicated that younger age (adjusted OR 0.86, 95% CI 0.77-0.95; p <0.005), lower body mass index (adjusted OR 0.87, 95% CI 0.77-0.98; p <0.05) and better Mini-Mental State Examination performance (adjusted OR 1.16, 95% CI 1.01-1.32; p <0.05) before surgery predicted favorable 5-year outcome. Conclusions This extended follow-up showed that the self-evaluated HRQoL outcome is associated with iNPH patients' pre-operative cognitive status, overweight and age. The post-operative deterioration may reflect the natural progression of iNPH, but also derive from aging and comorbidities. It indicates a need for long-term follow-up.Peer reviewe

Cryptic invasion drives phenotypic changes in central European threespine stickleback

Cryptic invasions are commonly associated with genetic changes of the native species or genetic lineage that the invaders replace. Phenotypic shifts resulting from cryptic invasions are less commonly reported given the relative paucity of historical specimens that document such phenotypic changes. Here, I study such a case in two populations of threespine stickleback from central Europe, comparing contemporary patterns of gene flow with phenotypic changes between historical and contemporary population samples. I find gene flow from an invasive lineage to be associated with significant phenotypic changes, where the degree of phenotypic change corresponds with the level of gene flow that a population receives. These findings underline the utility of combining genetic approaches with phenotypic data to estimate the impact of gene flow in systems where anthropogenic alterations have removed former geographic barriers promoting cryptic invasions

The greenhouse gas impacts of converting food production in England and Wales to organic methods

Agriculture is a major contributor to global greenhouse gas (GHG) emissions and must feature in efforts to reduce emissions. Organic farming might contribute to this through decreased use of farm inputs and increased soil carbon sequestration, but it might also exacerbate emissions through greater food production elsewhere to make up for lower organic yields. To date there has been no rigorous assessment of this potential at national scales. Here we assess the consequences for net GHG emissions of a 100% shift to organic food production in England and Wales using life-cycle assessment. We predict major shortfalls in production of most agricultural products against a conventional baseline. Direct GHG emissions are reduced with organic farming, but when increased overseas land use to compensate for shortfalls in domestic supply are factored in, net emissions are greater. Enhanced soil carbon sequestration could offset only a small part of the higher overseas emissions