237 research outputs found
Attitudes Toward Bisexuality According to Sexual Orientation and Gender
Despite increasing support for lesbian and gay individuals, the same degree of tolerance has not extended to bisexual individuals, and bisexual invisibility and biphobia are continuing problems that affect the mental health and well-being of people who are bisexual. There is evidence that attitudes toward people who are bisexual may vary by one\u27s own sexual orientation or gender. In the present study, the authors examined differences in attitudes toward people who are bisexual by sexual orientation and gender. The authors also asked participants who were bisexual to describe their experiences of being stigmatized. This study found significant effects for sexual orientation but not for gender; specifically, heterosexual participants reported significantly more biphobia and negative bisexual attitudes than participants who were gay, lesbian, or bisexual. Further, participants who were bisexuals reported feeling most stigmatized by individuals who were heterosexual. The results of this study indicate that attitudes toward bisexuality differ by sexual orientation but not by gender. The authors suggest implications for the mental health and well-being of people who are bisexual as well as possible interventions
Critical Casimir forces in colloidal suspensions on chemically patterned surfaces
We investigate the behavior of colloidal particles immersed in a binary
liquid mixture of water and 2,6-lutidine in the presence of a chemically
patterned substrate. Close to the critical point of the mixture, the particles
are subjected to critical Casimir interactions with force components normal and
parallel to the surface. Because the strength and sign of these interactions
can be tuned by variations in the surface properties and the mixtures
temperature, critical Casimir forces allow the formation of highly ordered
monolayers but also extend the use of colloids as model systems.Comment: 4 papges, 4 figures, accepted at Phys. Rev. Let
A Complexity View of Rainfall
We show that rain events are analogous to a variety of nonequilibrium
relaxation processes in Nature such as earthquakes and avalanches. Analysis of
high-resolution rain data reveals that power laws describe the number of rain
events versus size and number of droughts versus duration. In addition, the
accumulated water column displays scale-less fluctuations. These statistical
properties are the fingerprints of a self-organized critical process and may
serve as a benchmark for models of precipitation and atmospheric processes.Comment: 4 pages, 5 figure
Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila
Recent work in several model organisms has revealed that apoptotic cells are able to stimulate neighboring surviving cells to undergo additional proliferation, a phenomenon termed apoptosis-induced proliferation. This process depends critically on apoptotic caspases such as Dronc, the Caspase-9 ortholog in Drosophila, and may have important implications for tumorigenesis. While it is known that Dronc can induce the activity of Jun N-terminal kinase (JNK) for apoptosis-induced proliferation, the mechanistic details of this activation are largely unknown. It is also controversial if JNK activity occurs in dying or in surviving cells. Signaling molecules of the Wnt and BMP families have been implicated in apoptosis-induced proliferation, but it is unclear if they are the only ones. To address these questions, we have developed an efficient assay for screening and identification of genes that regulate or mediate apoptosis-induced proliferation. We have identified a subset of genes acting upstream of JNK activity including Rho1. We also demonstrate that JNK activation occurs both in apoptotic cells as well as in neighboring surviving cells. In a genetic screen, we identified signaling by the EGFR pathway as important for apoptosis-induced proliferation acting downstream of JNK signaling. These data underscore the importance of genetic screening and promise an improved understanding of the mechanisms of apoptosis-induced proliferation
Drag forces on inclusions in classical fields with dissipative dynamics
We study the drag force on uniformly moving inclusions which interact
linearly with dynamical free field theories commonly used to study soft
condensed matter systems. Drag forces are shown to be nonlinear functions of
the inclusion velocity and depend strongly on the field dynamics. The general
results obtained can be used to explain drag forces in Ising systems and also
predict the existence of drag forces on proteins in membranes due to couplings
to various physical parameters of the membrane such as composition, phase and
height fluctuations.Comment: 14 pages, 7 figure
Tunability of Critical Casimir Interactions by Boundary Conditions
We experimentally demonstrate that critical Casimir forces in colloidal
systems can be continuously tuned by the choice of boundary conditions. The
interaction potential of a colloidal particle in a mixture of water and
2,6-lutidine has been measured above a substrate with a gradient in its
preferential adsorption properties for the mixture's components. We find that
the interaction potentials at constant temperature but different positions
relative to the gradient continuously change from attraction to repulsion. This
demonstrates that critical Casimir forces respond not only to minute
temperature changes but also to small changes in the surface properties.Comment: 4 figures;
http://www.iop.org/EJ/article/0295-5075/88/2/26001/epl_88_2_26001.htm
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