The effectiveness of interventions targeting physical activity and/or sedentary behaviour in people with Multiple Sclerosis: a systematic review

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Validity of the activPAL3 activity monitor in people moderately affected by Multiple Sclerosis

Background: Walking is the primary form of physical activity performed by people with Multiple Sclerosis (MS), therefore it is important to ensure the validity of tools employed to measure walking activity. The aim of this study was to assess the criterion validity of the activPAL3 activity monitor during overground walking in people with MS.\ud Methods: Validity of the activPAL3 accelerometer was compared to video observation in 20 people moderately affected by MS. Participants walked 20-30m twice along a straight quiet corridor at a comfortable speed.\ud Results: Inter-rater reliability of video observations was excellent (all intraclass correlations > 0.99). The mean difference (activPAL3- mean of raters) was -4.70 ± 9.09, -4.55 s ± 10.76 and 1.11 s ± 1.11 for steps taken, walking duration and upright duration respectively. These differences represented 8.7, 10.0 and 1.8% of the mean for each measure respectively. The activPAL3 tended to underestimate steps taken and walking duration in those who walked at cadences of ≤ 38 steps/minute by 60% and 47% respectively.\ud Discussion: The activPAL3 is valid for measuring walking activity in people moderately affected by MS. It is accurate for upright duration regardless of cadence. In participants with slow walking cadences, outcomes of steps taken and walking duration should be interpreted with caution

Testing the Universality of the Stellar IMF with Chandra and HST

The stellar initial mass function (IMF), which is often assumed to be universal across unresolved stellar populations, has recently been suggested to be "bottom-heavy" for massive ellipticals. In these galaxies, the prevalence of gravity-sensitive absorption lines (e.g. Na I and Ca II) in their near-IR spectra implies an excess of low-mass ($m <= 0.5$ $M_\odot$) stars over that expected from a canonical IMF observed in low-mass ellipticals. A direct extrapolation of such a bottom-heavy IMF to high stellar masses ($m >= 8$ $M_\odot$) would lead to a corresponding deficit of neutron stars and black holes, and therefore of low-mass X-ray binaries (LMXBs), per unit near-IR luminosity in these galaxies. Peacock et al. (2014) searched for evidence of this trend and found that the observed number of LMXBs per unit $K$-band luminosity ($N/L_K$) was nearly constant. We extend this work using new and archival Chandra X-ray Observatory (Chandra) and Hubble Space Telescope (HST) observations of seven low-mass ellipticals where $N/L_K$ is expected to be the largest and compare these data with a variety of IMF models to test which are consistent with the observed $N/L_K$. We reproduce the result of Peacock et al. (2014), strengthening the constraint that the slope of the IMF at $m >= 8$ $M_\odot$ must be consistent with a Kroupa-like IMF. We construct an IMF model that is a linear combination of a Milky Way-like IMF and a broken power-law IMF, with a steep slope ($\alpha_1=$ $3.84$) for stars < 0.5 $M_\odot$ (as suggested by near-IR indices), and that flattens out ($\alpha_2=$ $2.14$) for stars > 0.5 $M_\odot$, and discuss its wider ramifications and limitations.Comment: Accepted for publication in ApJ; 7 pages, 2 figures, 1 tabl

Production of pulsed atomic oxygen beams via laser vaporization methods

Energetic pulsed atomic oxygen beams were generated by laser-driven evaporation of cryogenically frozen ozone/oxygen films and thin films of indium-tin oxide (ITO). Mass and energy characterization of beams from the ozone/oxygen films were carried out by mass spectrometry. The peak flux, found to occur at 10 eV, is estimated from this data to be 3 x 10(20) m(-2) s(-1). Analysis of the time-of-flight data indicates a number of processes contribute to the formation of the atomic oxygen beam. The absence of metastable states such as the 2p(3) 3s(1) (5S) level of atomic oxygen blown off from ITO films is supported by the failure to observe emission at 777.3 nm from the 2p(3) 3p(1) (5P sub J) levels. Reactive scattering experiments with polymer film targets for atomic oxygen bombardment are planned using a universal crossed molecular beam apparatus

The Otterbein Miscellany - May 1965

https://digitalcommons.otterbein.edu/miscellany/1011/thumbnail.jp

Flight Demonstration of Novel Atmospheric Satellite Concept

The major focus of the Phase II effort described herein is to develop and demonstrate an aircraft capable of autonomously sailing (i.e., to cruise without propulsion or external assistance), and thereby prove that the dual-aircraft platform (DAP) atmospheric satellite concept is potentially viable. This sailing mode of flight was identified as the number-1 enabling technology required for the stratospheric DAP concept (also known as Stratosat) in the NIAC (NASA Innovative Advanced Concept) Phase I effort. No scientific demonstration of this technology has ever been done or documented to our knowledge. This report describes efforts to take a major step towards the sailing mode of flight capability using a single aircraft connected by cable to a moving ground vehicle which uses sufficient crosswind to cruise without propulsion while "pulling" the ground vehicle forward (i.e., without external assistance). The development of a prototype aircraft is described in terms of novel and key hardware and software elements. A specialized prototype aircraft is described, including a novel cable release mechanism, novel "lateron" control surfaces, and a highly-accurate onboard wind measurement system. Additionally, a novel means to safely connect the aircraft to the moving ground vehicle is described involving a fishing rod/reel and integrated load cell. All of these devices were designed and developed in-house and validated in flight testing. Software is developed to provide look-up tables that give the flight condition targets (i.e., 3-D position relative to ground vehicle, forward speed, aircraft orientation, etc.), based on current wind speed and direction. These tables are successfully validated in flight simulation and used onboard the aircraft. High fidelity analysis of the aircraft aerodynamics are described - required to produce accurate target sailing flight conditions. A novel wind tunnel measurement technique is developed to accurately assess the aerodynamics of the ultra-thin cable. A new specialized flight simulator is described which is utilized to develop and verify the flight software required onboard the aircraft, and to support training of pilots for flying the aircraft while tethered to a ground vehicle. The DAP flight simulator was developed within the Matlab-Simulink framework and included detailed treatment of aircraft/cable aerodynamics, cable dynamics, experimentally-derived propeller-motor thrust curves, actuator responsiveness, and realistic air turbulence. The specialized formation flight controller algorithm, developed using this flight simulator, and onboard the aircraft is described. Finally, a novel auto-tuning software is described and verified within the flight simulator that is shown to refine the sailing flight condition targets during flight using an optimization technique involving doublet maneuvers. Virtual flights using the auto-tuning software indicate that the prototype aircraft should be able to reach and hold sailing conditions despite moderate levels of turbulence provided there is sufficient mean wind available. An overview of the flight testing program is provided. Hundreds of short flights were conducted, primarily using a dead short runway at Deland Municipal Airport which permitted use of a moving ground vehicle. Additional flight tests at Space Floridas Shuttle Landing Facility are also described. First year results from these tests in which the aircraft is controlled manually, demonstrated that excessive flight testing would be required for a pilot to learn to sail with visual cues. However, second year results from autonomous flight these tests included successful demonstration of the closed-loop autonomous formation flight capability (i.e., autonomously determine, reach, and hold the required 3-D location relative to the ground vehicle required for sailing). The next step of using the auto-tune software to autonomously refine the aircraft orientation targets to finally achieve sailing remains the primary goal of future work

Search for a T-odd, P-even Triple Correlation in Neutron Decay

Background: Time-reversal-invariance violation, or equivalently CP violation, may explain the observed cosmological baryon asymmetry as well as signal physics beyond the Standard Model. In the decay of polarized neutrons, the triple correlation D\cdot(p_{e}\timesp_{\nu}) is a parity-even, time-reversal- odd observable that is uniquely sensitive to the relative phase of the axial-vector amplitude with respect to the vector amplitude. The triple correlation is also sensitive to possible contributions from scalar and tensor amplitudes. Final-state effects also contribute to D at the level of 1e-5 and can be calculated with a precision of 1% or better. Purpose: We have improved the sensitivity to T-odd, P-even interactions in nuclear beta decay. Methods: We measured proton-electron coincidences from decays of longitudinally polarized neutrons with a highly symmetric detector array designed to cancel the time-reversal-even, parity-odd Standard-Model contributions to polarized neutron decay. Over 300 million proton-electron coincidence events were used to extract D and study systematic effects in a blind analysis. Results: We find D = [-0.94\pm1.89(stat)\pm0.97(sys)]e-4. Conclusions: This is the most sensitive measurement of D in nuclear beta decay. Our result can be interpreted as a measurement of the phase of the ratio of the axial-vector and vector coupling constants (CA/CV= |{\lambda}|exp(i{\phi}_AV)) with {\phi}_AV = 180.012{\deg} \pm0.028{\deg} (68% confidence level) or to constrain time-reversal violating scalar and tensor interactions that arise in certain extensions to the Standard Model such as leptoquarks. This paper presents details of the experiment, analysis, and systematic- error corrections.Comment: 21 pages, 22 figure