Specialized business incubators as a strategy for small and medium-sized enterprises in the industry 4.0 era – a systemic approach

The present research aims to get a holistic view of the characteristics of specialization in business incubators models. This paper centers on building a general framework by taking into account a holistic look at the features, profiles, advantages, and disadvantages of specialization in business incubators models. The strategy aims to impact mainly stakeholders by adopting business incubators strategies, especially to those tenant firms of the manufacturing sector related to emerging technologies such as Industry 4.0 technologies. Moreover, the framework is built based on the discussion of the leading representatives' heads of the specialization in the field of specialized business incubators' models. The strategy aims to reduce the current short-term death rate expectancy prevailing in the contemporary economic context by a robust business model for business incubation. Business incubators hold tenants into a hub with not only supportive facilities for the business without investing vital capital, which is not part of their core chain value but also harnessing the closer source of knowledge transfer and skilfully workforce-related on these technologies. Finally, remarks and recommendations are proposed for futures tenant companies' prospects, who wish to reduce the bankruptcy risk by boosting innovative goods and services with high technological development in a specific field of knowledge.N/

Efficacy of antiemetic therapy in patients undergoing laparoscopic cholecystectomy

AbstractIntroductionA high incidence of postoperative nausea and vomiting has been observed in patients undergoing laparoscopic cholecystectomy (20–40%). This causes an increase in patient discomfort, a delay in recovery, and an increase in hospital stay.ObjectiveCompare the efficacy of ondansetron plus metoclopramide and ondansetron alone in the control of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.Material and methodsA comparative, prospective, experimental, longitudinal double blind study was performed with 30 patients programmed for laparoscopic cholecystectomy. The Apfel score was applied postoperatively. Patients were divided into two groups with 15 participants. Metoclopramide 10mg and ondansetron 4mg were administered in the first Group (A), and ondansetron 4mg in the second Group (B), after induction of anesthesia. Nausea and vomiting were evaluated for 24h postoperatively using a Likert scale.ResultsOf the patients who presented nausea, the condition was mild. The patient who presented vomiting, vomited only once. Neither group required rescue drugs. Regarding the Apfel score, there was no correlation between the percentage of stratified risk and the patients who presented postoperative nausea and vomiting.ConclusionsNo statistically significant difference was observed between ondansetron plus metoclopramide and ondansetron alone in patients subjected to laparoscopic cholecystectomy

Towards sustainable industrial development - a systems thinking-based approach

Various critical global issues, including global warming and poverty, have been recognized and identified by the United Nations (UN) as drivers for unsustainability. Consequently, the UN established the Sustainable Development Goals (SDGs) with the aim of seeking universal peace and larger freedom by balancing the three dimensions of sustainable development, i.e. economic, social and environmental. A particular attention SDGs pay is in eradicating poverty as this is considered one of the greatest global challenges. Poverty is not only an economic matter as it also has an impact on the social and environmental dimensions. A strategy to tackle poverty is to foster industry development. However, a holistic point of view is necessary by also considering stakeholders otherwise, it becomes a neoliberal solution. Despite the fact that some research has been conducted, e.g. case studies and surveys of sustainable practices, there is a lack of industrial sustainable development as a framework to tackle sustainability issues. Thus, this paper proposes a framework for industrial sustainable development under a socially inclusive approach within the context of the Mexican manufacturing industry. The framework proposal is based on a state-of-the-art literature review conducted in the Web of Science and Scopus databases.N/

Modifications to the delivery of a gross anatomy course during the COVID-19 pandemic at a Mexican medical school

The Coronavirus disease was declared a pandemic this year, causing an impact on medical education. Following the World Health Organization’s (WHO) recommendations, Universities around the world implemented social distancing and the use of online platforms. Anatomists lead medical students, most of which are part of Generation Z. Different technological tools have been used in the gross anatomy course in combination with face-toface classes, but now are forced to move exclusively online. The Human Anatomy Department in the Medical School of the Universidad Autonoma de Nuevo León (UANL) implemented asynchronous sessions as a short-term resolution, transformed to synchronous sessions as the pandemic progressed. It is important to consider the adaptability of the student, the near-peer teacher, and academic staff, with the creation of innovative ideas to facilitate the learning for the student and to maintain the quality of the course. Their role in this modality should be assessed, as it may change medical education and the way to teach in the future for the new generation of medical students. Professors’ roles are changing and it is necessary to adapt to new situations

Antimicrobial Activity of a Cationic Guanidine Compound against Two Pathogenic Oral Bacteria

This study evaluated the potential antimicrobial properties of a polyguanidine (CatDex) on two oral bacteria. Chlorhexidine gluconate 1340 μmoL L−1 (CHX 0.12%) was used as control. Streptococcus mutans (S. mutans) and Porphyromonas gingivalis (P. gingivalis) were grown in BHI media. Bacterial sensitivity and antimicrobial activity were determined by the minimum inhibitory concentration (MIC) and Kirby-Bauer methods. To study side effects, that is, toxicity, dental pulp stem cells (DPSCs) were used. Fluorometric cytotoxicity and confocal microscopy assays were used in order to test cell viability. CatDex inhibited growth of S. mutans at all concentrations and growth of P. gingivalis at all concentrations except 25 μmoL L−1. The MIC of CatDex was 50 μmoL L−1 for both S. mutans and P. gingivalis. The inhibition of bacteria exposed for 8 h at 50 μmoL L−1 of CatDex exhibited increased antimicrobial activity over time, with 91% inhibition in both bacteria. The antimicrobial activities of CatDex and CHX were similar when tested on two common bacteria. CatDex was significantly less toxic to DPSCs. CatDex toxicity depended on time and not on concentration. With regard to clinical relevance, CatDex may have potential as a novel antimicrobial agent. Further studies are in progress

Continuación del programa de desarrollo de habilidades interpersonales en una empresa de servicio de transporte: manejo de conflictos y negociación

El nombre del proyecto de este PAP es Continuación del programa de desarrollo de habilidades interpersonales en una empresa de servicio de trasporte: Manejo de Conflictos y Negociación y el propósito general se basa en su relación con dos PAP’s anteriores. En el PAP de otoño 2021 el proyecto con el que se trabajó fue: “Realización de un diagnóstico para tipificar la cultura organizacional, en una empresa dedicada al transporte de personal, con el objetivo de fortalecer su proceso de cambio estratégico”. El propósito general fue diagnosticar la cultura organizacional de la empresa. Esta intervención fue la primera que la empresa tuvo con la universidad. Después de esto en el PAP de primavera 2022 se seleccionaron los temas a través de una reunión del equipo PAP junto con un grupo de colaboradores de la empresa, tales como la directora general y la coordinadora del talento humano. Se decidió de manera conjunta, que la empresa requiere darle continuación a las acciones pasadas para abordar las problemáticas en las áreas de comunicación efectiva, liderazgo y trabajo en equipo, además de que se requiere la capacitación para el manejo del conflicto y la capacidad de negociación por parte de los colaboradores. Durante este PAP nos enfocamos en brindar talleres abordando principalmente los últimos dos temas. Los talleres se impartieron a 4 grupos de dos sesiones cada uno. Además de esto, se dio continuación a un grupo del PAP de primavera 2022 abordando los temas de comunicación, liderazgo y trabajo en equipo.ITESO, A.C

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Yeasts associated with the production of distilled alcoholic beverages

Distilled alcoholic beverages are produced firstly by fermenting sugars emanating from cereal starches (in the case of whiskies), sucrose-rich plants (in the case of rums), fructooligosaccharide-rich plants (in the case of tequila) or from fruits (in the case of brandies). Traditionally, such fermentations were conducted in a spontaneous fashion, relying on indigenous microbiota, including wild yeasts. In modern practices, selected strains of Saccharomyces cerevisiae are employed to produce high levels of ethanol together with numerous secondary metabolites (eg. higher alcohols, esters, carbonyls etc.) which greatly influence the final flavour and aroma characteristics of spirits following distillation of the fermented wash. Therefore, distillers, like winemakers, must carefully choose their yeast strain which will be very important in providing the alcohol content and the sensory profiles of spirit beverages. This Chapter discusses yeast and fermentation aspects associated with the production of selected distilled spirits and highlights similarities and differences with the production of wine