Wind measurements from an array of oceanographic moorings and from F/SMeteor during JASIN 1978

During the Joint Air-Sea Interaction (JASIN) experiment conducted in the northern Rockall Trough in the summer of 1978, oceanographic moorings with surface buoys carrying wind recorders were deployed in an array designed to investigate the variability of the near-surface wind field at scales of from 2 to 200 km. The wind records together with observations taken on board the research vessels participating in JASIN have provided ground truth measurements for the sea surface wind velocity sensors on the Seasat satellite. During most of the experiment the wind field was characterized by spatial scales large in comparison with the separations between the buoys. On several occasions, spatial differences associated with cold fronts were identified, and it was possible to track the passage of the front through the array. However, quantitative analysis of the variability of the wind field was complicated both by a lack of data due to mechanical failures of some instruments and by significant differences in the performance of the diverse types of wind recorders. Reevaluation of the instruments used in JASIN and recent comparison of some of these instruments with more conventional sets of wind sensors confirm the possibility that there is significant error in the JASIN wind measurements made from the buoys. In particular, the vector-averaging wind recorder on W2, which was one of the few instruments to recover a full length record and which was chosen during a Seasat-JASIN workshop as the JASIN standard, had performance characteristics that were among the most difficult to explain

SUMSS: A Wide-Field Radio Imaging Survey of the Southern Sky. I. Science goals, survey design and instrumentation

The Molonglo Observatory Synthesis Telescope, operating at 843 MHz with a 5 square degree field of view, is carrying out a radio imaging survey of the sky south of declination -30 deg. This survey (the Sydney University Molonglo Sky Survey, or SUMSS) produces images with a resolution of 43" x 43" cosec(Dec.) and an rms noise level of about 1 mJy/beam. SUMSS is therefore similar in sensitivity and resolution to the northern NRAO VLA Sky Survey (NVSS; Condon et al. 1998). The survey is progressing at a rate of about 1000 square degrees per year, yielding individual and statistical data for many thousands of weak radio sources. This paper describes the main characteristics of the survey, and presents sample images from the first year of observation.Comment: 27 pages, 12 figures (figures 2, 8, 10 in jpg format); AJ, in pres

Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies.

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by a high metastatic burden, already at the time of diagnosis. The metastatic potential of PDAC is one of the main reasons for the poor outcome next to lack of significant improvement in effective treatments in the last decade. Key mutated driver genes, such as activating KRAS mutations, are concordantly expressed in primary and metastatic tumors. However, the biology behind the metastatic potential of PDAC is not fully understood. Recently, large-scale omic approaches have revealed new mechanisms by which PDAC cells gain their metastatic potency. In particular, genomic studies have shown that multiple heterogeneous subclones reside in the primary tumor with different metastatic potential. The development of metastases may be correlated to a more mesenchymal transcriptomic subtype. However, for cancer cells to survive in a distant organ, metastatic sites need to be modulated into pre-metastatic niches. Proteomic studies identified the influence of exosomes on the Kuppfer cells in the liver, which could function to prepare this tissue for metastatic colonization. Phosphoproteomics adds an extra layer to the established omic techniques by unravelling key functional signaling. Future studies integrating results from these large-scale omic approaches will hopefully improve PDAC prognosis through identification of new therapeutic targets and patient selection tools. In this article, we will review the current knowledge on the biology of PDAC metastasis unravelled by large scale multi-omic approaches

Gas and Dust Emission from the Nuclear Region of the Circinus Galaxy

Simultaneous modeling of the line and continuum emission from the nuclear region of the Circinus galaxy is presented. Composite models which include the combined effect of shocks and photoionization from the active center and from the circumnuclear star forming region are considered. The effects of dust reradiation, bremsstrahlung from the gas and synchrotron radiation are treated consistently. The proposed model accounts for two important observational features. First, the high obscuration of Circinus central source is produced by high velocity and dense clouds with characteristic high dust-to-gas ratios. Their large velocities, up to 1500 km\s, place them very close to the active center. Second, the derived size of the line emitting region is well in agreement with the observed limits for the coronal and narrow line region of Circinus.Comment: 36 pages, LaTex (including 4 Tables and 9 figures), $$ removed from Abstract To appear in "The Astrophysical Journal

The association between premorbid cognitive ability and social functioning and suicide among young men: A historical-prospective cohort study

Previous studies have found associations between low cognitive ability and later completed suicide. The aim of this study was to examine the association between cognitive ability and social functioning in adolescence, and later completed suicide in a large population-based longitudinal study. Data from the Israeli Draft Board Register for 634,655 Israeli male adolescents aged 16 and 17 was linked to a causes-of-death data registry, with a mean follow-up of 10.6 years for completed suicide. Our results show that in males without a psychiatric diagnosis, both low (adjusted HR=1.51, 95% CI: 1.19–1.92) and high (adjusted HR=1.36, 95% CI: 1.04–1.77) cognitive ability, and very poor (adjusted HR=2.30, 95% CI: 1.34–3.95) and poor (adjusted HR=1.64, 95% CI: 1.34–2.07) social functioning were associated with increased risk for later completed suicide; however positive predictive values were low (PPVs=0.09% and 0.10%, for low cognitive ability and very poor or poor social functioning, respectively). No association between cognitive ability or social functioning and risk for suicide was found in males with a psychiatric diagnosis. These data do not support the clinical utility of screening for such potential predictors

The Molonglo Galactic Plane Survey: I. Overview and Images

The first epoch Molonglo Galactic Plane Survey (MGPS1) is a radio continuum survey made using the Molonglo Observatory Synthesis Telescope (MOST) at 843 MHz with a resolution of 43" X 43" cosec |delta|. The region surveyed is 245 deg < l < 355 deg, |b| < 1.5 deg. The thirteen 9 deg X 3 deg mosaic images presented here are the superposition of over 450 complete synthesis observations, each taking 12 h and covering 70' X 70' cosec |delta|. The root-mean-square sensitivity over much of the mosaiced survey is 1-2 mJy/beam (1 sigma), and the positional accuracy is approximately 1" X 1" cosec |delta| for sources brighter than 20 mJy. The dynamic range is no better than 250:1, and this also constrains the sensitivity in some parts of the images. The survey area of 330 sq deg contains well over 12,000 unresolved or barely resolved objects, almost all of which are extra-galactic sources lying in the Zone of Avoidance. In addition a significant fraction of this area is covered by extended, diffuse emission associated with thermal complexes, discrete H II regions, supernova remnants, and other structures in the Galactic interstellar medium.Comment: Paper with 3 figures and 1 table + Table 2 + 7 jpg grayscales for Fig 4. Astrophysical Journal Supplement (in press) see also http://www.astrop.physics.usyd.edu.au/MGP

D-Instantons and asymptotic geometries

The large N limit of D3-branes is expected to correspond to a superconformal field theory living on the boundary of the anti-de Sitter space appearing in the near-horizon geometry. Dualizing the D3-brane to a D-instanton, we show that this limit is equivalent to a type IIB S-duality. In both cases one effectively reaches the near-horizon geometry. This provides an alternative approach to an earlier derivation of the same result that makes use of the properties of a gravitational wave instead of the D-instanton.Comment: 17 pages, LaTeX, 1 figure, minor corrections and refs adde

Atmosphere drives recent interannual variability of the Atlantic meridional overturning circulation at 26.5°N

The RAPID-MOCHA array has observed the Atlantic Meridional overturning circulation (AMOC) at 26.5°N since 2004. During 2009/2010, there was a transient 30% weakening of the AMOC driven by anomalies in geostrophic and Ekman transports. Here, we use simulations based on the Met Office Forecast Ocean Assimilation Model (FOAM) to diagnose the relative importance of atmospheric forcings and internal ocean dynamics in driving the anomalous geostrophic circulation of 2009/10. Data assimilating experiments with FOAM accurately reproduce the mean strength and depth of the AMOC at 26.5°N. In addition, agreement between simulated and observed stream functions in the deep ocean is improved when we calculate the AMOC using a method that approximates the RAPID observations. The main features of the geostrophic circulation anomaly are captured by an ensemble of simulations without data-assimilation. These model results suggest that the atmosphere played a dominant role in driving recent interannual variability of the AMOC

Radio Frequency Spectra of 388 Bright 74 MHz Sources

As a service to the community, we have compiled radio frequency spectra from the literature for all sources within the VLA Low Frequency Sky Survey (VLSS) that are brighter than 15 Jy at 74 MHz. Over 160 references were used to maximize the amount of spectral data used in the compilation of the spectra, while also taking care to determine the corrections needed to put the flux densities from all reference on the same absolute flux density scale. With the new VLSS data, we are able to vastly improve upon previous efforts to compile spectra of bright radio sources to frequencies below 100 MHz because (1) the VLSS flux densities are more reliable than those from some previous low frequency surveys and (2) the VLSS covers a much larger area of the sky (declination >-30 deg.) than many other low frequency surveys (e.g., the 8C survey). In this paper, we discuss how the spectra were constructed and how parameters quantifying the shapes of the spectra were derived. Both the spectra and the shape parameters are made available here to assist in the calibration of observations made with current and future low frequency radio facilities.Comment: Accepted to ApJ

Birth and Evolution of Isolated Radio Pulsars

We investigate the birth and evolution of Galactic isolated radio pulsars. We begin by estimating their birth space velocity distribution from proper motion measurements of Brisken et al. (2002, 2003). We find no evidence for multimodality of the distribution and favor one in which the absolute one-dimensional velocity components are exponentially distributed and with a three-dimensional mean velocity of 380^{+40}_{-60} km s^-1. We then proceed with a Monte Carlo-based population synthesis, modelling the birth properties of the pulsars, their time evolution, and their detection in the Parkes and Swinburne Multibeam surveys. We present a population model that appears generally consistent with the observations. Our results suggest that pulsars are born in the spiral arms, with a Galactocentric radial distribution that is well described by the functional form proposed by Yusifov & Kucuk (2004), in which the pulsar surface density peaks at radius ~3 kpc. The birth spin period distribution extends to several hundred milliseconds, with no evidence of multimodality. Models which assume the radio luminosities of pulsars to be independent of the spin periods and period derivatives are inadequate, as they lead to the detection of too many old simulated pulsars in our simulations. Dithered radio luminosities proportional to the square root of the spin-down luminosity accommodate the observations well and provide a natural mechanism for the pulsars to dim uniformly as they approach the death line, avoiding an observed pile-up on the latter. There is no evidence for significant torque decay (due to magnetic field decay or otherwise) over the lifetime of the pulsars as radio sources (~100 Myr). Finally, we estimate the pulsar birthrate and total number of pulsars in the Galaxy.Comment: 27 pages, including 15 figures, accepted by Ap