On volatile element trends in gas-rich meteorites

Ten volatile elements (and non-volatile Co) in co-existing light and dark portions of 5 gas-rich chondrites were studied. Patterns of distinct but non-uniform enrichment by dark admixing material are revealed. The dark admixing material is enriched in Cs; Bi and Tl covary in it. It is compositionally unique from known types of primitive materials and is apparently not derived by secondary processes from such materials

Normal stresses in semiflexible polymer hydrogels

Biopolymer gels such as fibrin and collagen networks are known to develop tensile axial stress when subject to torsion. This negative normal stress is opposite to the classical Poynting effect observed for most elastic solids including synthetic polymer gels, where torsion provokes a positive normal stress. As recently shown, this anomalous behavior in fibrin gels depends on the open, porous network structure of biopolymer gels, which facilitates interstitial fluid flow during shear and can be described by a phenomenological two-fluid model with viscous coupling between network and solvent. Here we extend this model and develop a microscopic model for the individual diagonal components of the stress tensor that determine the axial response of semi-flexible polymer hydrogels. This microscopic model predicts that the magnitude of these stress components depends inversely on the characteristic strain for the onset of nonlinear shear stress, which we confirm experimentally by shear rheometry on fibrin gels. Moreover, our model predicts a transient behavior of the normal stress, which is in excellent agreement with the full time-dependent normal stress we measure.Comment: 12 pages, 8 figure

Modeling group-specific interviewer effects on survey participation using separate coding for random slopes in multilevel models

Despite its importance in terms of survey participation, the literature is sparse on how face-to-face interviewers differentially affect specific groups of sample units. In this paper, we demonstrate how an alternative parametrization of the random components in multilevel models, so-called separate coding, delivers valuable insights into differential interviewer effects for specific groups of sample members. At the example of a face-to-face recruitment interview for a probability-based online panel, we detect small interviewer effects regarding survey participation for non-Internet households, whereas we find sizable interviewer effects for Internet households. Based on the proposed variance decomposition, we derive practical guidance for survey practitioners to address such differential interviewer effects

Ab initio calculations of the physical properties of transition metal carbides and nitrides and possible routes to high-Tc

Ab initio linear-response calculations are reported of the phonon spectra and the electron-phonon interaction for several transition metal carbides and nitrides in a NaCl-type structure. For NbC, the kinetic, optical, and superconducting properties are calculated in detail at various pressures and the normal-pressure results are found to well agree with the experiment. Factors accounting for the relatively low critical temperatures Tc in transition metal compounds with light elements are considered and the possible ways of increasing Tc are discussed.Comment: 19 pages, 7 figure

The first histidine triad motif of phtd is critical for zinc homeostasis in Streptococcus pneumoniae

Streptococcus pneumoniae is the world's foremost human pathogen. Acquisition of the first row transition metal ion zinc is essential for pneumococcal colonization and disease. Zinc is acquired via the ATP-binding cassette transporter AdcCB and two zinc-binding proteins, AdcA and AdcAII. We have previously shown that AdcAII is reliant upon the polyhistidine triad (Pht) proteins to aid in zinc recruitment. Pht proteins generally contain five histidine (His) triad motifs that are believed to facilitate zinc binding and therefore play a significant role in pneumococcal metal ion homeostasis. However, the importance and potential redundancy of these motifs have not been addressed. We examined the effects of mutating each of the five His triad motifs of PhtD. The combination of in vitro growth assays, active zinc uptake, and PhtD expression studies show that the His triad closest to the protein's amino terminus is the most important for zinc acquisition. Intriguingly, in vivo competitive infection studies investigating the amino- and carboxyl-terminal His triad mutants indicate that the motifs have similar importance in colonization. Collectively, our new insights into the contributions of the individual His triad motifs of PhtD, and by extension the other Pht proteins, highlight the crucial role of the first His triad site in zinc acquisition. This study also suggests that the Pht proteins likely play a role beyond zinc acquisition in pneumococcal virulence

Modelling Group-Specific Interviewer Effects on Nonresponse Using Separate Coding for Random Slopes in Multilevel Models

To enhance response among underrepresented groups and hence, to increase response rates and to decrease potential nonresponse bias survey practitioners often use interviewers in population surveys (Heerwegh, 2009). While interviewers tend to increase overall response rates in surveys (see Heerwegh, 2009), research on the determinants of nonresponse have also identified human interviewers as one reason for variations in response rates (see for examples Couper & Groves, 1992; Durrant, Groves, Staetsky, & Steele, 2010; Durrant & Steele, 2009; Hox & de Leeuw, 2002; Loosveldt & Beullens, 2014; West & Blom, 2016). In addition, research on interviewer effects indicates that interviewers introduce nonresponse bias, if interviewers systematically differ in their success in obtaining response from specific respondent groups (see West, Kreuter, & Jaenichen, 2013; West & Olson, 2010). Therefore, interviewers might be a source of selective nonresponse in surveys. Interviewers might also differentially contribute to selective nonresponse in surveys and hence, potential nonresponse bias, when interviewer effects are correlated with characteristics of the approached sample units (for an example see Loosveldt & Beullens, 2014). Multilevel models including dummies in the random part of the model to distinguish between respondent groups are commonly used to investigate whether interviewer effects on nonresponse differ across specific respondent groups (see Loosveldt & Beullens, 2014). When dummy coding, which is also referred to as contrast coding (Jones, 2013), are included as random components in multilevel models for interviewers effects, the obtained variance estimates indicate to what extent the contrast between respondent groups varies across interviewers. Yet, such parameterization does not directly yield insight on the size of interviewer effects for specific respondent groups. Surveys with large imbalances among respondent groups gain from an investigation of the variation of interviewer effect sizes on nonresponse, as one gains insights on whether the interviewer effect size is the same for specific respondent groups. The importance of the interviewer effect size for specific groups of respondents lies in its prediction of the effectiveness of interviewer-related fieldwork strategies (for examples on liking, matching, or prioritizing respondents with interviewers see Durrant et al., 2010; Peytchev, Riley, Rosen, Murphy, & Lindblad, 2010; Pickery & Loosveldt, 2002, 2004) and thus, a effective mitigation of potential nonresponse bias. Consequently, understanding group-specific interviewer effect sizes can aide the efficiency of respondent recruitment, because we then understand why some interviewer-related fieldwork strategies have great impact on some respondent group’s participation while other strategies have little effect. To obtain information on differences in interviewer effect size, we propose to use an alternative coding strategy, so-called separate coding in multilevel models with random slopes (for examples see Jones, 2013; Verbeke & Molenberghs, 2000, ch. 12.1). In case of separate coding, every variable represents a direct estimate of the interviewer effects for specific respondent groups (rather than the contrast with a reference category). Investigating nonresponse during the recruitment of a probability-based online panel separately for persons with and without prior internet access (data used from the German Internet Panel, see Blom et al., 2017), we detect that the size of the interviewer effect differs between the two respondent groups. While we discover no interviewer effects on nonresponse for persons without internet access (offliners), we find sizable interviewer effects for persons with internet access (onliners). In addition, we identify interviewer characteristics that explain this group-specific nonresponse. Our results demonstrate that the implementation of interviewer-related fieldwork strategies might help to increase response rates among onliners, as for onliners the interviewer effect size was relatively large compared to the interviewer effect size for offliners

HIV-1 superinfection with a triple-class drug-resistant strain in a patient successfully controlled with antiretroviral treatment.

We report a case of HIV-1 superinfection (HSI) with a clade B, triple-class resistant virus in a patient successfully controlling viremia with continuous combination antiretroviral therapy started 8 years earlier during primary HIV infection. The course of HIV infection prior to HSI was monitored in both the source partner and recipient (8 and 11 years, respectively) and 4 years following HSI. This case report demonstrates re-infection with HIV-1 despite effective combination antiretroviral therapy

HIV-1 superinfection with a triple-class drug-resistant strain in a patient successfully controlled with antiretroviral treatment.

We report a case of HIV-1 superinfection (HSI) with a clade B, triple-class resistant virus in a patient successfully controlling viremia with continuous combination antiretroviral therapy started 8 years earlier during primary HIV infection. The course of HIV infection prior to HSI was monitored in both the source partner and recipient (8 and 11 years, respectively) and 4 years following HSI. This case report demonstrates re-infection with HIV-1 despite effective combination antiretroviral therapy