An Evaluation of the Relationship Smarts Plus Program on Adolescents in Georgia

The present study examines the impact of Relationship Smarts Plus among 1,657 adolescents age 12-18 across 25 Georgia counties. The program, aimed at increasing awareness about healthy versus unhealthy relationships and promoting smart dating strategies and the application of healthy communication and conflict resolution skills, was offered 54 times by 23 different FCS or 4-H agents during a 53-month period. After each lesson, participants completed a 5-item retrospective pre- and post-test assessing changes in awareness and understanding of the concepts and skills learned. Overall, 949 (57%) youth responded to an overall post-evaluation administered at the conclusion of the program series to document confidence levels in having a healthy relationship, likelihood of using the skills learned, perceived helpfulness of the program, and changes in how youth felt about themselves. On average, youth demonstrated significant increases in knowledge for all lessons and reported positive improvements across all post-evaluation indicators following participation in the program. Implications for future youth-focused outreach programming to promote healthy relationships are shared

Therapy for Irregular Menstruation with Acupunture and Herbal Pegagan (Centella Asiatica (L.))

Background : Menstruation is bleeding periodic scale and cyclical from uterus extrication (deskuamasi) endometrium. Menstruation bleeding is complex interaction result wich involve hormone system and body system, that are hypothalamus, hypofisis, ovarium and uterus. Every woman has different menstruation cycle. The causes of irregular menstruation are genetic and bad habit life. While according to TCM, irregular menstruation is Yue Jing Bu Tiao. Purpose : to knowing the effect of acupuncture therapy and point of Guanyuan (CV 4), Shenshu (BL 23), Sanyinjao (SP 6) and Shenmen (HT 7). Therapy was given 12 times, 3 times every week. Herbal therapy wich given was pegagan (Centella asiatica (L)) with dose 0,3 and consumed everyday after eat. Result : therapy that used acupuncture and herbal in irregular menstruation case showing menstruation cycle change, that was menstruation cycle became shorter from 76 days to 41 days. Conclusion : acupuncture therapy on point of Guanyuan (CV 4), Shenshu (BL 23), Sanyinjao (SP 6), Shenmen (HT 7), and pegagan herbal (Centella asiatica (L)) could shorten menstruation cycle from 76 days to 41 days

Bidirectional Associations Between Coparenting Relations and Family Member Anxiety: A Review and Conceptual Model

Research into anxiety has largely ignored the dynamics of family systems in anxiety development. Coparenting refers to the quality of coordination between individuals responsible for the upbringing of children and links different subsystems within the family, such as the child, the marital relationship, and the parents. This review discusses the potential mechanisms and empirical findings regarding the bidirectional relations of parent and child anxiety with coparenting. The majority of studies point to bidirectional associations between greater coparenting difficulties and higher levels of anxiety. For example, the few available studies suggest that paternal and perhaps maternal anxiety is linked to lower coparental support. Also, research supports the existence of inverse links between coparenting quality and child anxiety. A child’s reactive temperament appears to have adverse effects on particularly coparenting of fathers. A conceptual model is proposed that integrates the role of parental and child anxiety, parenting, and coparenting, to guide future research and the development of clinical interventions. Future research should distinguish between fathers’ and mothers’ coparenting behaviors, include parental anxiety, and investigate the coparental relationship longitudinally. Clinicians should be aware of the reciprocal relations between child anxiety and coparenting quality, and families presenting for treatment who report child (or parent) anxiety should be assessed for difficulties in coparenting. Clinical approaches to bolster coparenting quality are called for.FSW – Publicaties zonder aanstelling Universiteit Leide

Projection of snowfall extremes in the French Alps as a function of elevation and global warming level

Following the projected increase in extreme precipitation, an increase in extreme snowfall may be expected in cold regions, e.g. for high latitudes or at high elevations. By contrast, in low/medium elevation areas, the probability to experience rainfall instead of snowfall is generally projected to increase due to warming conditions. In mountainous areas, despite the likely existence of these contrasted trends according to elevation, changes in extreme snowfall with warming remain poorly quantified. This paper assesses projected changes in heavy and extreme snowfall, i.e. in mean annual maxima and 100-year return levels, in the French Alps as a function of elevation and global warming level using a recent methodology based on non-stationary extreme value models. This methodology is applied to an ensemble of 20 adjusted GCM-RCM pairs from the EURO-CORDEX experiment under the scenario RCP8.5. available for each of the 23 massifs of the French Alps from 1951 to 2100, and every 300 m of elevations. Results are provided as relative or absolute changes computed w.r.t. current climate conditions, at the massif scale and averaged over all available massifs. Overall, mean annual maxima are projected to decrease below 3000 m and increase above 3600 m, while 100-year return levels are projected to decrease below 2400 m and increase above 3300 m. At elevations in between, values are on average projected to increase until +3 &deg;C of global warming, and then decrease. At +4 &deg;C, average relative changes in mean annual maxima and 100-year return levels respectively vary from &minus;26 % (&minus;7 kg m&minus;2) and &minus;15 % (&minus;11 kg m&minus;2) at 900 m, to +3 % (+3 kg m&minus;2) and +8 % (+13 kg m&minus;2) at 3600 m. Finally, for each global warming level, we compute the elevation threshold that separates contrasted trends, i.e. where the average relative change equals zero. This elevation threshold is projected to rise between +1.5 &deg;C and +4 &deg;C: from 3000 m to 3350 m for mean annual maxima, and from 2600 m to 3000 m for 100-year return levels. These results have implications for the management of risks related to extreme snowfall.</p

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal chelators and ligands represent potential therapeutic agents for AD treatment. A direct effect of metal chelators on γ-secretase has not yet been investigated. The authors used an in vitro  γ-secretase assay consisting of cleavage of APP C100-3XFLAG by endogenous γ-secretase from rodent brains and human neuroblastoma SH-SY5Y, and detected AICD production by western blotting. Adding metalloprotease inhibitors to the reaction showed that clioquinol, phosphoramidon, and zinc metalloprotease inhibitors had no significant effect on γ-secretase activity. In contrast, phenanthroline, EDTA, and EGTA markedly decreased γ-secretase activity that could be restored by adding back calcium and magnesium ions. Mg2+ stabilized a 1,000 kDa presenilin 1 complex through blue native gel electrophoresis and size-exclusion chromatography. Data suggest that Ca2+ and Mg2+ stabilize γ-secretase and enhance its activity

A new species of stygobitic snail in the genus Antrorbis Hershler & Thompson, 1990 (Gastropoda, Cochliopidae) from the Appalachian Valley and Ridge of eastern Tennessee, USA

A new species of cave snail (Littorinimorpha: Cochliopidae) in the genus Antrorbis is described from the dark zone of two caves in the Appalachian Valley and Ridge province in eastern Tennessee, United States. The Tennessee Cavesnail, Antrorbis tennesseensis Perez, Shoobs, Gladstone, & Niemiller, sp. nov. is distinguished from its only known congener, Antrorbis breweri, by the absence of raised tubercles on its finely spirally striate protoconch, and its unique radular formula. Moreover, A. tennesseensis is genetically distinct from A. breweri based on substantial divergence at the mitochondrial CO1 locus. This is the first cavesnail to be described from the Appalachian Valley and Ridge (AVR) physiographic province in the state of Tennessee, which previously represented a substantial gap in the distribution of stygobitic (i.e., aquatic, subterranean-obligate) gastropods